Transcriptome Archives

A deep-ocean submersible uses its lights to illuminate a hydrothermal vent field at Chammoro Seamount, within the Mariana Trench, June 24, 2016. Source NOAA Office of Ocean Exploration and Research/NOAA

Analog Studies, Arctic / Antarctic / Alpine, Away Teams & Field Reports, Biochemistry & Organic Chemistry, Biogeochemical Cycles & Geobiology, Biophysics, Biosignatures & Paleobiology, Extremeophiles and Extreme Environments, Gaia - Planetary Perspectives, Genomics, Proteomics, Bioinformatics, Habitable Zones, Microbiology & Virology, Missions & Hardware, Nomenclature, Systematics, Natural History, Origin & Evolution of Life, Planetary Protection & Biosafety, Robotics/Rovers/UAVs, ROVs/Submersibles/Diving, Sample Return, Status Report, Tricorders & Sensors, Water/Hycean Worlds & Oceanography

Editorial: Life Under Pressure: Microbial Adaptation And Survival In High Pressure Environments

by Keith CowingMarch 11, 2026March 11, 2026

A quantitative overview of Earth’s biomass has long been lacking, despite its importance for understanding the biosphere. The first global estimate—approximately 550 gigatons of carbon (Gt C)—reveals stark disparities across […]

Pan-evolutionary analysis for identifying conserved gene clusters and karyotypes. (A–C) Microsynteny analysis among deep ocean organisms. Circos plot for distribution and visualization of microsynteny blocks between two deep ocean organisms. - HKUST

Analog Studies, Away Teams & Field Reports, Biogeochemical Cycles & Geobiology, Biosignatures & Paleobiology, Cryobiology, Extremeophiles and Extreme Environments, Gaia - Planetary Perspectives, Genomics, Proteomics, Bioinformatics, Habitable Zones, Microbiology & Virology, Nomenclature, Systematics, Natural History, Press Release, ROVs/Submersibles/Diving, Sample Return, Water/Hycean Worlds & Oceanography

HKUST Launches World’s First Deep-sea Multi-omics Resource Platform Empowering Global Research Into Biological Adaptation In Extreme Environments

by Keith CowingDecember 30, 2025December 30, 2025

The Hong Kong University of Science and Technology (HKUST), in collaboration with the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), has launched the world’s first Deep Ocean Omics (DOO) […]

Assembly of ribonucleoprotein condensates in response to Mars-like stress conditions. Credit Dhage et al. -- Indian Institute of Science (IISc)

Analog Studies, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Extremeophiles and Extreme Environments, Mars, Microbiology & Virology, Press Release

Yeast Survives Martian Conditions

by Keith CowingOctober 15, 2025October 15, 2025

Any life on Mars in the past, present, or future would have to contend with challenging conditions including, among others, shock waves from meteorite impacts and soil perchlorates—highly oxidizing salts […]

Morphology of K. pneumoniae in simulated microgravity and in normal gravity- NPJ Microgravity

Microbiology & Virology, Microgravity, Planetary Protection & Biosafety, Press Release, Space Life Science, Space Stations

Phenotypic, Transcriptomic and Metabolomic Changes In Klebsiella pneumoniae After Long Term Exposure To Simulated Microgravity

by Keith CowingJuly 20, 2025July 20, 2025

Klebsiella pneumoniae (K. pneumoniae) has been detected on space stations.

Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Microgravity, Radiation, Space Life Science, Space Stations, Status Report

Rotifers In Space: Transcriptomic Response Of The Bdelloid Rotifer Adineta vaga Aboard The International Space Station

by Keith CowingJuly 18, 2025July 18, 2025

This study analyzes the transcriptomic changes experienced by Adineta vaga, a bdelloid rotifer aboard the International Space Station (ISS), using RNA sequencing.

Image courtesy of University of Toyama. Date Created:2025-05-28 https://images.nasa.gov/details/jsc2025e047405

Genomics, Proteomics, Bioinformatics, Imaging & Spectroscopy, Microgravity, Plant Biology, Space Agriculture, Space Life Science, Space Stations, Status Report

Offworld Life Science: Visualized Microtubules In Cell Cultures

by Keith CowingMay 30, 2025May 28, 2025

Taken on 28 May 2025, this image of the preparative zone of cultured tobacco cells with visualized microtubules (yellow: microtubules [preparative zone], magenta: nuclei).

Log2 fold change heatmap of the “spaceflight signatures in mice” in 27 datasets with 10 different mouse tissues. Age (Day). Duration (Day). 1,288 up-regulated and 896 down-regulated genes. -- Nature via Pub Med

Away Teams & Field Reports, Genomics, Proteomics, Bioinformatics, Microgravity, Space Life Science, Space Physiology & Medicine, Status Report

Sequencing The Inspiration 4 Crew’s Genomic Responses To Spaceflight

by Keith CowingMarch 18, 2025March 18, 2025

Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew.

Schematic structure of denitrification genes in HRV44T and their gene and protein expression levels -- iScience

Atmospheres, Climate, Weather, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Extremeophiles and Extreme Environments, Habitable Zones, Microbiology & Virology, Origin & Evolution of Life, Press Release, ROVs/Submersibles/Diving, Sample Return, Water/Hycean Worlds & Oceanography

Understanding The Molecular Mechanisms Involved In Nitrous Oxide Reduction By Deep-sea Hydrothermal Vent Bacteria

by Keith CowingDecember 13, 2024December 13, 2024

Nitrous oxide (N2O) is the third most potent greenhouse gas after carbon dioxide and methane. It can also be oxidized by physical processes to form ozone-depleting substances. Atmospheric concentrations of […]

Overall pipeline of GLARE: Gene LAb Representation learning pipelinE. (a) Illustration of GLARE, starting with a verification study followed by preprocessing through detecting outliers using k-means clustering. Using the clean dataset, GLARE provides options for representation learning from PCA to state-of-the-art SAE pre-trained with high-throughput single-cell data. Retrieved data representation is then processed through ensemble clustering to find the hidden patterns within the data. Results from the verification study and ensemble clustering are then used for post-pipeline analysis. (b) Model architecture illustration of employed SAE for both training with and without pre-training. (c) Ensemble clustering using three base clustering algorithms based on different statistical methodologies. Evidence accumulation clustering is used to derive consensus clusters from these algorithms. -- biorxiv.org

AI - Data - Apps - Cybernetics, Genomics, Proteomics, Bioinformatics, Gravitational Biology, Microgravity, Nanotechnology & SynBio, Space Life Science, Status Report

GLARE: Discovering Hidden Patterns In Spaceflight Transcriptome Using Representation Learning

by Keith CowingJune 9, 2024June 9, 2024

Spaceflight studies present novel insights into biological processes through exposure to stressors outside the evolutionary path of terrestrial organisms. Despite limited access to space environments, numerous transcriptomic datasets from spaceflight […]

Comparative analysis of minimum energetic costs for cellular synthesis across different organisms at different temperatures calculated using synercell.

Biochemistry & Organic Chemistry, Biophysics, Genomics, Proteomics, Bioinformatics, Status Report

The Minimum Energy Required To Build A Cell

by Keith CowingMarch 27, 2024March 27, 2024

Understanding the energy requirements for cell synthesis accurately and comprehensively has been a longstanding challenge. We introduce a computational model that estimates the minimum energy necessary to build any cell […]

Transcriptome

Editorial: Life Under Pressure: Microbial Adaptation And Survival In High Pressure Environments

HKUST Launches World’s First Deep-sea Multi-omics Resource Platform Empowering Global Research Into Biological Adaptation In Extreme Environments

Yeast Survives Martian Conditions

Phenotypic, Transcriptomic and Metabolomic Changes In Klebsiella pneumoniae After Long Term Exposure To Simulated Microgravity

Rotifers In Space: Transcriptomic Response Of The Bdelloid Rotifer Adineta vaga Aboard The International Space Station

Offworld Life Science: Visualized Microtubules In Cell Cultures

Sequencing The Inspiration 4 Crew’s Genomic Responses To Spaceflight

Understanding The Molecular Mechanisms Involved In Nitrous Oxide Reduction By Deep-sea Hydrothermal Vent Bacteria

GLARE: Discovering Hidden Patterns In Spaceflight Transcriptome Using Representation Learning

The Minimum Energy Required To Build A Cell

Exoplanet Beta Pictoris d Found After More Than 10 Years Of Searching

When Stabilizing Feedbacks Wreak Havoc In Habitable Planets: Chaos At The Freezing Point In A Four-Feedback Climate Model

Biosignature Detectability On Transiting Habitable Worlds With ELT/ANDES

Rising From The Fragments: A Multi-factorial Regulatory Framework Of DNA Damage Response In Deinococcus radiodurans

NAS Committee On Planetary Protection Seeks Membership Suggestions