Introduction – Cryo-hypersaline brines combine sub-zero temperatures with near-saturated salinity, creating one of Earth’s most extreme habitats. Antarctic Deep Lake provides a natural model for studying how proteins remain stable […]
Proteome
Posted inBiogeochemical Cycles & Geobiology, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
Deep-time Consistency In Proteome Elemental Composition Across Cellular And Viral Life
Proteins are constructed from a limited alphabet of ~20 amino acids, yet the origins and selection of this specific alphabet are unresolved.
Posted inBiochemistry & Organic Chemistry, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Press Release
Minimal Amino Acid Alphabet for Protein Design
Proteins are built from 20 canonical amino acids. It is interesting to explore whether proteins can be formed from significantly reduced amino acid alphabets.
Posted inAstropharmacy / Biotechnology, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Press Release
Millions Of Protein Complexes Added To AlphaFold Database Shed Light On How Proteins Interact
A new collaboration between EMBL’s European Bioinformatics Institute (EMBL-EBI), Google DeepMind, NVIDIA, and Seoul National University has made millions of AI-predicted protein complex structures openly available through the AlphaFold Database. […]
Posted inBiochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
Molecular Complexity Constrained Early Amino Acid Recruitment into the Genetic Code
Previously proposed chronologies of amino acid incorporation into the genetic code rely on consensus rankings derived from prebiotic synthesis experiments, biosynthetic pathways, or genomic trends.
Posted inAnalog Studies, Arctic / Antarctic / Alpine, Away Teams & Field Reports, Biophysics, Biosignatures & Paleobiology, Cryobiology, Extremeophiles and Extreme Environments, Habitable Zones, Microbiology & Virology, Sample Return, Status Report
Cytoplasmic Fluidity And The Cold Life: Proteome Stability Is Decoupled From Viability In Psychrophiles
Protein diffusion, critical for cellular metabolism, occurs in the highly crowded cytoplasm. Understanding how this dynamics changes when organisms are adapted to different thermal niches is a fundamental challenge in […]
Posted inBiochemistry & Organic Chemistry, Biogeochemical Cycles & Geobiology, Biosignatures & Paleobiology, Extremeophiles and Extreme Environments, Microbiology & Virology, Sample Return, Status Report
Life In The Brine Of Lunenburg, Germany: Unveiling Microorganisms Associated With Zechstein Salt Deposits
Introduction: The presence of hypersaline brines on other planets and moons in the inner and outer Solar System has been well established.
Posted inAway Teams & Field Reports, Biogeochemical Cycles & Geobiology, Biophysics, Biosignatures & Paleobiology, Extremeophiles and Extreme Environments, Genomics, Proteomics, Bioinformatics, Habitable Zones, Microbiology & Virology, Sample Return, Status Report
Genome Sequence And Methylome Of The Extremely Halophilic Bacterium Salinibacter Ruber Strain M31T Isolated From A Crystallizer Pond In Mallorca, Spain
Salinibacter ruber strain M31T, an extremely halophilic bacterium, was isolated from a saltern crystallizer pond in Spain. Single-molecule real-time sequencing revealed a 3.6-Mbp genome with a single 3.55-Mbp circular chromosome […]
Posted inGenomics, Proteomics, Bioinformatics, Imaging & Spectroscopy, Microgravity, Plant Biology, Space Agriculture, Space Life Science, Space Stations, Status Report
Offworld Life Science: Visualized Microtubules In Cell Cultures
Taken on 28 May 2025, this image of the preparative zone of cultured tobacco cells with visualized microtubules (yellow: microtubules [preparative zone], magenta: nuclei).
Posted inStatus Report
Tricorder Tech: Single-Cell Proteomics Using Mass Spectrometry
Editor’s note: If we aspire to mount expeditions to new worlds and then embrace the task of characterizing and quantifying whatever life forms we find, the ability to map and […]