[The Hebrew University of Jerusalem] Researchers have identified a simple form of molecular cooperation that may have helped life’s earliest building blocks become more stable and organized.
Origin & Evolution of Life
Posted inGenomics, Proteomics, Bioinformatics
Pinpointing Where Cells First Begin Copying DNA
[Medical Research Council (MRC) Laboratory of Medical Sciences] Every time a cell divides, it must faithfully copy its entire genetic instruction manual. Errors during this process can damage the genome, […]
Posted inExtremeophiles and Extreme Environments
From Mars to Minas: Research Reclassifies Organisms That Thrive In Highly Saline Environments
[JORNAL DA USP – Universidade de São Paulo] Organisms that defy life by thriving in environments where most other living beings could not survive. To date, there is no scientific […]
![Recombination transferred part of archaeal YRS into non-canonical bacterial YRS. A) YRS core catalytic domain alignment from archaeal (indicated left as blue), bacterial non-canonical (purple) and bacterial canonical (pink) sequences. Both recombinant and nonrecombinant YRSs are found within all four major bacterial supergroups (Terrabacteria, Proteobacteria, PVC and FCB) B) Speciestree reconciled consensus trees reconstructed for the non-recombinant (left) and recombinant YRS sites (right). Branch lengths were estimated using NQ.bac+R10 in IQ-Tree v2.1.332. -- [biorxiv.org]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/Tryptophan-became.png?resize=1200%2C720&ssl=1)
Posted inOrigin & Evolution of Life
Tryptophan Became Part Of The Universal Genetic Code Post-LUCA
[biorxiv.org] We evaluate whether tryptophan (W), widely thought to be the last of the 20 canonical amino acids added to the genetic code, was already present in the Last Universal […]
![Hypergraph percolation accelerates the emergence of large-scale biological organization. The growth of integrated organizational complexity is compared in systems governed by pairwise interactions and higher-order hypergraph interactions. Complexity is quantified as the percentage of elementary units incorporated into the largest connected organizational assembly as interaction density increases. The pairwise model exhibits a gradual increase in connectivity, whereas the hypergraph model displays a sharp transition associated with the formation of extensive higherorder connectivity. Inset A enlarges the transition region and shows the growth of the largest connected component as a function of interaction density. Therefore, higher-order interactions can generate abrupt increases in large-scale organization through hypergraph percolation dynamics. -- [q-bio.OT]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/From-simple-interactions.png?resize=1200%2C720&ssl=1)
Posted inOrigin & Evolution of Life
From Simple Interactions To Complex Biology: A Hypergraph Percolation Perspective
[q-bio.OT] The emergence of biological complexity can be viewed as a transition from fragmented local interactions to extensive integrated organization, raising the question of how large-scale connectivity emerges from simple […]
![a) Biological evolution as stochastic optimization: Initially, wild-type cells x grow up a population. A mutant y grows up a population. The populations x and y compete. The winner (greater population) then fetches more resources. Fitness landscapes at the bottom show how the mutant is an experiment, where the winner decides the next step direction. b) Evolution annotated in terms of the Central Dogma: (Left, green) Wildtype starting point, NA encodes PR, which gives fitness F. (Top, red), Mutation in the blueprint NA, becoming NA’. (Red, green) both NA sequences grow up into populations. (Next) The populations compete for fitness. The winner, Fx now carries with it the winning sequence NAx and protein P Rx. -- [biorxiv.org]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/RNA-And-Proteins.png?resize=1200%2C720&ssl=1)
Posted inOrigin & Evolution of Life
RNA And Proteins Joined Up At The Origins Of Life: Persistence Is The Point
[biorxiv.org] What drove nucleic acids (NA) to associate with proteins (PR) at the Origins of Life? We reason from polymer physics and the Central Dogma (CD) that the fitness value […]
![Most theoretical work on the origin of heredity has focused on how genetic information can be maintained without mutational degradation in the absence of error-proofing systems. -- [PLOS Biology]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/Selection-For.png?resize=1200%2C715&ssl=1)
Posted inGenomics, Proteomics, Bioinformatics
Selection For Growth Drives The Emergence Of Genetic Heredity In Protocells
[PLOS Biology] A simple and parsimonious solution assumes the first gene sequences evolved inside dividing protocells, which enables selection for functional sets. But this model of information maintenance does not […]
![This study reports the first formation of (E)-phosphinimine (HPNH, X1A′) – the simplest iminophosphane – in low-temperature interstellar model ices composed of phosphine (PH3) and ammonia (NH3) exposed to galactic cosmic ray proxies. -- [Chemical Science]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/Non-equilibrium.png?resize=1200%2C720&ssl=1)
Posted inBiochemistry & Organic Chemistry
Non-equilibrium Preparation Of (E)-phosphinimine (HPNH, X1A′) – A Precursor To Prebiotic Phosphorylating Agents
[Chemical Science] Phosphorus–nitrogen compounds play crucial roles as intermediates in aza-Wittig reactions and serve as key precursors to prebiotic phosphorylating agents such as amidophosphonates linked to the Origins of Life.
Posted inWater/Hycean Worlds & Oceanography
Deep-sea Creatures’ Epic Migrations Between Hydrothermal Vents
[University of Tokyo] Hydrothermal vents on the bottom of the ocean host a broad range of rare and unusual ecosystems. They can be spread very far apart, and yet there […]
Posted inImpact events
Researchers Identify Class Of Oddball Meteorite That Killed Earth’s Dinosaurs
[University of British Columbia] A rare CO chondrite meteorite was the probable impactor that struck Earth 66 million years ago, wiping out 75 per cent of Earth’s species, including non-avian […]