NASA Spaceline Current Awareness List #1,177 5 December 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Pham J, Nandi SP, Balaian L, Engstrom C, Chang P, Mack K, van der Werf I, Klacking E, Sneifer J, Katragadda N, Wirtjes K, Ruiz A, Chilin-Fuentes D, Molina E, Mesci P, Stoudemire J, Morris SR, Whisenant T, Alexandrov LB, Jamieson CHM.Space-associated stem cell hallmarks of aging and resilience in astronauts.Cell Stem Cell. 2025 Dec 4;32(12): p1886-1903.e7.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 20.4
   
   Funding: “We would like to acknowledge the significant contributions of the Axiom 2, Axiom 3, and Axiom 4 astronauts; Michelle Ortiguerra, MBA; and other members of the UC San Diego Sanford Stem Cell Institute (SSCI) and the Salk Institute NGS Core Facility. We are grateful to our funding agencies for their vital support, including NASA (NRA NNJ13ZBG001N), NCI (R01CA296974), NCI (R01CA205944), NIH/NIDDK (R01DK114468-01), NIH NCI CCSG p30CA023100, NIH NCI CCSG P30 CA01495, NIH NIA San Diego Nathan Shock Center (P30 AG068635), The Chapman Foundation and the Helmsley Charitable Trust, LLS Blood Cancer Discoveries, SSCI, the Koman Family Foundation, the JM Foundation, and the Moores Family Foundation.”
2. Tays GD, Fettrow TD, McGregor HR, Hupfeld KE, De Dios YE, Reuter-Lorenz PA, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler RD.Sensory network segregation as a predictor of post spaceflight balance impairments and sensory re-weighting.npj Microgravity. 2025 Nov 27;11:85.PIs: H.R. McGregor, A.P. Mulavara, S.J. Wood, R.D. SeidlerNote: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA 80NSSC18K0783) to R.S., A.M., S.W., and J.B. During the completion of this work G.T. was supported by the University of Florida’s (UF) Graduate Student Funding Award and by NIH T32-NS082128. K.H. was supported by National Institute on Aging fellowships (F99AG068440 and K00AG068440). H.M. was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship and a NASA Human Research Program Augmentation Grant. The authors would like to thank all the astronauts who volunteered their time, without them this project would not have been possible.”
3. Pitcher LE, Mukherjee B, Saathoff AM, Eduvas ZA, Bartz J, Zhang X, Giorgadze N, Pirtskhalava T, Habib AA, LeBrasseur NK, Tchkonia T, Kirkland JL, Dong X, Burma S, Robbins PD.Space radiation induces distinct senescent phenotypes: Implications for space travel.npj Aging. 2025 Nov 27;11:95.PI: S. BurmaNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 6.0
   
   Funding: “Funding for this research was provided by grants from NASA 80NSSC20K0732 (SB) and NIH R01 CA246807 (SB), R01 AG069819 (PDR), P01 AG043376 (PDR), U19 AG056278 (PDR), P01 AG062413 (PDR, JLK, NKL), U54 AG079754 (PDR), U54 AG076041 (PDR), R37AG013925 (JLK), R33AG061456 (JLK) and T32AG029796 (LEP).”
4. Sevilla-García M, Quivira-Lopesino A, Cuesta P, Pusil S, Bruña R, Fiedler P, Maestu F, Cebolla AM, Cheron G, Brauns K, Stahn AC, Funke ME.Brain power comparison between microgravity and head-down tilt bedrest: An electroencephalography approach.Sci Rep. 2025 Nov 27;15:42314.PI: M.E. FunkeNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.9
   
   Funding: “Presented EEG data analysis (M.S.G., A.Q.L., P.C., S.P., R.B., P.F., M.F., F.M.) is supported by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (Clinical trial number: not applicable). Obtaining the original EEG data, here used for comparison, from several ISS expeditions was funded by the Belgian Federal Science Police Office (A.C., G.C.), the European Space Agency (ESA), (AO-2004, 118 for A.C., G.C.; AO-2009-BR and AO-2013-BR for A.C.S), the Belgian National Funds for Scientific Research (G.C.), the research funds of the Université Libre de Bruxelles (A.C., G.C.), and the Université de Mons-Hainaut (G.C.). The HDBR data were obtained via research grant 50WB1525 (A.C.S.) supported by the European Space Agency and by the German Aerospace Center (DLR, Deutsches Zentrum für Luft- und Raumfahrt).”
5. Alexeev Y, Farag MH, Patti TL, Wolf ME, Ares N, Aspuru-Guzik A, Benjamin SC, Cai Z, Cao S, Chamberland C, Chandani Z, Fedele F, Hamamura I, Harrigan N, Kim JS, Kyoseva E, Lietz JG, Lubowe T, McCaskey A, Melko RG, Nakaji K, Peruzzo A, Rao P, Schmitt B, Stanwyck S, Tubman NM, Wang H, Costa T.Artificial intelligence for quantum computing.Nat Commun. 2025 Dec 2;16:10829. Review.Journal Impact Factor: 15.7
   
   Funding: N.M. Tubman is affiliated with NASA Ames Research Center.

Other papers of interest:

1. Arjmand F, Taherkhani S, Shahrezaei A, Sohani M, Esfahani SS, Marjaei S, Nasirinezhad F.Neural changes in microgravity: Investigating the effects of aerospace environments.IBRO Neurosci Rep. 2025 Dec;19:973-80. Review.Note: This article may be obtained online without charge.
2. Boschert AL, Leuko S, Krämer CL, Siems K, Ly-Sauerbrey YT, Arndt F.Spaceflight and medical microbiology: Possible implications for standard infection diagnostics and therapy.Life (Basel). 2025 Nov 15;15(11):1757.Note: This article is part of section “Microbiology” (https://www.mdpi.com/journal/life/sections/microbiology) and may be obtained online without charge.
3. Honjo M, Hasegawa T, Muratani M, Bochimoto H.Meta-analysis of Ocy-454 showed interrupted osteocyte maturation in spaceflight affects SOST expression and hypoxic response.J Clin Med. 2025 Nov 15;14(22):8100.Note: From the abstract: “We used the NASA GeneLab Database (https://genelab.nasa.gov) OSD-324, which is a microarray of data about the Ocy454 osteocytic cell line cultured for 2, 4, and 6 days during spaceflight, and the GSE102958 microarray in the Gene Expression Omnibus. We also analyzed the characteristics of SOST gene expression in osteocytes during spaceflight using merged datasets.” This article is part of section “Orthopedics” (https://www.mdpi.com/journal/jcm/sections/Orthopedics) and may be obtained online without charge.
4. Kaspranski RR, Binhi VN, Koshel IV.Human responses to magnetic and hypomagnetic fields: Available evidence and potential risks for deep space travel.Life (Basel). 2025 Nov 18;15(11):1766. Review.Note: This article is part of section “Astrobiology” (https://www.mdpi.com/journal/life/sections/astrobiology) and may be obtained online without charge.
5. Kaushik V, Paul S, Sahayanathan S, Anand S.Enhanced accuracy in radiation dose estimation for astronauts using mesh-type reference computational phantoms.Life Sci Space Res. 2025 Nov 26. Online ahead of print.
6. Kim S, Min K, Park YG, Moon SH.Stem cells in space: Microgravity effects on stem cell fate and implications for regenerative medicine.npj Microgravity. 2025 Dec 2. Review. Online ahead of print.Note: This article may be obtained online without charge.
7. Profitiliotis G.Enrichment of the driving metanarratives shared between SETI and space sustainability through a multispecies lens.Acta Astronaut. 2026 Feb;239:932-38.Note: From the abstract: “The fields of SETI and Space Sustainability appear to have significant conceptual common ground. This article argues that this cross-fertilization of ideas is the effect of socially-shared nonfictional narratives at work in each of the two fields, which are tacitly driven by the same cross-cutting metanarrative foundations.”
8. Vasilieva SN, Guk IV, Silnikov NM.A setup to test high altitude and astronaut helmets on blast and shock wave mitigation.Acta Astronaut. 2026 Mar;240:47-52.Note: From the abstract: “The article presents a methodology, experimental setup, and test results of an air shock wave action on helmets designed to protect astronauts and high-altitude pilots. Using a biomechanical head dummy with dynamic pressure sensor, the influence of having an open visor on the shock wave profile is demonstrated.”
9. Cai L, Liu Y, Li K, Xing C, Xu Z, Zhao L, Lv K, Li Z, Wang H, Wang L, Luo D, Yuan L, Qu L, Li Y, Wang Z, Ren P.Multimodal imaging-based cerebral blood flow prediction model development in simulated microgravity.Cyborg Bionic Syst. 2025 Nov 24;6:0448.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
10. Chen A, Guo C, Zhou Y.Effects of resistance training on preventing muscle atrophy and bone loss in simulated weightless population: A systematic review and meta-analysis.Front Physiol. 2025;16:1694891. Review.Note: This article is part of Research Topic “Acute and Chronic Physiological Adaptations to Resistance Exercises Across Various Populations: Mechanisms and Practical Applications” (https://www.frontiersin.org/research-topics/68187/acute-and-chronic-physiological-adaptations-to-resistance-exercises-across-various-populations-mechanisms-and-practical-applications/articles) and may be obtained online without charge.
11. Goulart JB.Space: Bone physiology’s final frontier.Physiology (Bethesda). 2025 Nov 25Note: This article is an editorial.
12. Jiang M, Shao J, Lin K, Lin L, Yue S, Yan H, Zhou J, Shi S, Li X, Zhang R.SIRT3 regulates PDHA1 acetylation in HUVECs to modulate inflammation and pyroptosis under clinorotation.iScience. 2025 Nov 21;28(11):113790.Note: This article may be obtained online without charge.
13. Kundu C, Sharma S, Ghosh T, Deepak KK, Das A.Short-term 6° head-down tilt bedrest simulating microgravity ameliorates blood pressure and heart rate variability: A quasi-experimental study on healthy adults.Life Sci Space Res. 2025 Nov 29. Online ahead of print.
14. Kuznetsov NV, Vlasova DD, Kotikova AA, Tomilovskaya E, Ljubisavljevic M.Microgravity impacts the expression of aging-associated candidate gene targets in the p53 regulatory network.Int J Mol Sci. 2025 Nov 18;26(22):11140.Note: From the abstract: “The extreme space environment accelerates aging and compromises human health. NASA has named five main hazards in space, including gravity changes. However, the contribution of each factor to the overall impact on biomolecular and cellular processes is not always clear. We aimed to explore the effects of microgravity on the transcriptomes of healthy volunteers, with a focus on gene expression in p53 pathways. Ten healthy men were exposed to dry immersion simulated microgravity (DI-SMG) for three weeks and blood samples were collected at five timepoints before, during and after the course of DI-SMG.” This article is part of Special Issue “New Trends in Biologically Active Compounds in Age-Related Diseases” (https://www.mdpi.com/journal/ijms/special_issues/24UGD0XM0G) and may be obtained online without charge.
15. Mammadov RA, van Hulten MPC, Bakker MK, Verhaar AP, Peppelenbosch MP.Microgravity activates monocyte ERK1/2 signaling and modulates the response to lipopolysaccharide.Mol Med. 2025 Nov 29. Online ahead of print.Note: From the abstract: “Monocytes were cultured during spaceflight under either normal gravity (1G) or microgravity (µG) and exposed to LPS or control conditions. MAPK activity was quantified and analyzed to assess basal signaling, stimulus responsiveness, and variability within the population.” This article may be obtained online without charge.
16. Mandić M, Lundberg TR, Frippiat JP, McDonnell AC, Mekjavić IB, Bareille MP, Billette de Villemeur R, Fernandez-Gonzalo R.Limited musculoskeletal benefits of artificial gravity combined with cycling during bedrest: Results from the BRACE study.Exp Physiol. 2025 Nov 29.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
17. Mendes Zambetta R, De Favari Signini É, Catai AM, Benelli A, Angius L, Dos Santos TCR, Michaliski ES, de Oliveira LB, Ocamoto GN, Santarnecchi E, Frigieri G, Russo TL.Effect of simulated microgravity via head-down tilt on intracranial compliance, brain oscillations and cardiovascular autonomic modulation.Sci Rep. 2025 Nov 27;15(1):42316.Note: This article may be obtained online without charge.
18. Moser D, Buchheim JI, Biere K, Matzel S, F DA, Choukér A, Woehrle T, Feuerecker M.Biological sex as a variable in immunity does not affect parabolic flight-induced alterations in immune responses.Front Immunol. 2025 Nov 16;16:1673072.Note: This article may be obtained online without charge.
19. Stead TE, Cvirn G, De Boever P, Bergauer A, Green DA, White O, Arron HE, Blaber AP, Goswami N.Blood coagulability changes in females exposed to dry immersion: Examining a mechanism for the development of venous thromboembolism in microgravity.Acta Astronaut. 2026 Mar;240:99-105.

astrobiology, Microgravity, space biology, space medicine, space station, spaceline,