NASA Spaceline Current Awareness List #1,134 31 January 2025 (Space Life Science Research Results)

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].

Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.

Papers deriving from NASA support:

1

Poveda L, Dash S, Madrid D, Devane K, Lenchik L, Tooze J, Weaver AA.

Thoracolumbar spine muscle size and composition changes in long-duration space missions.

Life Sci Space Res. 2025 Feb;44:1-8.

https://doi.org/10.1016/j.lssr.2024.11.003

PI: A.A. Weaver

Note: ISS results.

Journal Impact Factor: 2.9

Funding: “This work was supported by NASA (Grant No. NNX16AP89G).”

2

Chang HHV, Fesshaye AS, Tidmore A, Sanford LD, Britten RA.

Sleep fragmentation results in novel set-shifting decrements in GCR-exposed male and female rats.

Radiat Res. 2024 Nov 22;203(1):18-25.

https://doi.org/10.1667/RADE-24-00146.1

PI: R.A. Britten

Journal Impact Factor: 2.5

Funding: “This work was funded by NASA grants NNX14AE73G and NNX16AC40G.”

3

Sigdel S, Chen S, Udoh G, Wang J.

Exercise-intervened circulating extracellular vesicles alleviate oxidative stress in cerebral microvascular endothelial cells under hypertensive plus hypoxic conditions.

Antioxidants (Basel). 2025 Jan 10;14(1):77.

https://pubmed.ncbi.nlm.nih.gov/39857411

Note: This article is part of Special Issue “New Strategies in Preventing Inflammatory and/or Oxidative Stress-Induced Damages in Ischemia-Reperfusion Injury, 2nd Edition” (https://www.mdpi.com/journal/antioxidants/special_issues/61WG1KX18K) and may be obtained online without charge.

Journal Impact Factor: 10.6

Funding: “This work was partially supported by the NASA West Virginia Space Grant Consortium (80NSSC20M0055; SS), the American Heart Association (AHA) Career Development Award (935826; J.W.), the Pilot grant (J.W.) of the National Institute of General Medical Sciences (U54GM104942), and the AHA Transformational Project Award (24TPA1291189; J.W.).”

4

Lichtarge J, Cappuccio G, Pati S, Dei-Ampeh AK, Sing S, Ma L, Liu Z, Maletic-Savatic M.

MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets.

Front Neurosci. 2025 Jan 12;18:1520982.

https://doi.org/10.3389/fnins.2024.1520982

PI: M. Maletic-Savatic

Note: This article is part of Research Topic “Advancing Neurodevelopmental Disorder Models with Human iPSC and Multi-Omics Integration.” (https://www.frontiersin.org/research-topics/60535/advancing-neurodevelopmental-disorder-models-with-human-ipsc-and-multi-omics-integration) and may be obtained online without charge.

Journal Impact Factor: 3.2

Funding: “This work was supported in part by grants from the National Institute of General Medical Sciences (5R01GM120033 to M.M.S.), the National Institute of Aging (1R01AG076942 to M.M.S.), the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health, United States (P50 HD103555) IDDRC grant (Signature Project to M.M.S., the use of the Human Disease Cellular Models Core facility, and the use of the Microscopy Core facility) at Baylor College of Medicine, Houston, TX, United States. In addition, the support was provided by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A, grant RAD01013 (to M.M.S.), Autism Speaks (G.C., S.P.), and Cynthia and Antony Petrello Endowment (M.M.S.), the Chao Endowment (Z.L.) and the Huffington Foundation (Z.L.).”

5

Kiss JZ.

Statoliths function in gravity perception in plants: Yes, no, yes!

Planta. 2025 Jan 27;261(2):45. Review.

https://pubmed.ncbi.nlm.nih.gov/39869172

PI: J.Z. Kiss

Journal Impact Factor: 3.6

Funding: “The author thanks NASA for funding my research throughout many years.”

6

Anderson A, Stratton E, Nelson A, Lemery J, Berens K, Hilmers D, Lehnhardt K.

Development of progressively Earth-independent medical operations to enable NASA exploration missions.

Wilderness Environ Med. 2025 Jan 27;10806032241310386. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/39865932

Note: From the abstract: “The National Aeronautics and Space Administration’s (NASA’s) transition from operations in low-Earth orbit to long-duration missions to the Moon and Mars necessitates the development of progressively Earth-independent medical operations (EIMO) to support crews and reduce overall mission risk. Previous work has defined and laid the foundation for EIMO, but further development of the concept is required to prepare for future exploration missions.”

Journal Impact Factor: 1.4

Funding: J. Lemery and K. Lehnhardt are affiliated with NASA Johnson Space Center.

7

Habarakadage B, Rajendran S, Ren Z, Anderson MJ, Koehne J, Gorla L, Morita S, Wu S, Hua DH, Li J.

Mitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis.

Biosens Bioelectron. 2025 Apr;273:117193.

https://pubmed.ncbi.nlm.nih.gov/39864310

PI: M.J. Anderson

Note: From the abstract: “Proteases are overexpressed at various stages of conditions such as cancers and thus can serve as biomarkers for disease diagnosis. Electrochemical techniques to detect the activity of extracellular proteases have gained attraction due to their multiplexing capability. Here we employ an electrochemical approach based on a 3 × 3 gold (Au) microelectrode array (MEA) functionalized with (2-aminoethyl)ferrocene (AEF) tagged specific peptide substrates to monitor cathepsin B (CB) protease activity.”

Journal Impact Factor: 10.7

Funding: “This work was supported by NewHope BioDiagnostics LLC (NC, USA), the National Cancer Institute of the National Institutes of Health (USA) under the award number R01 CA217657, the Johnson Cancer Research Center at Kansas State University (USA), and the Translational Research Institute for Space Health (USA) through Cooperative Agreement NNX16AO69A.”

__________________________________________________

Other papers of interest:

1

Basner M, Strangman G, Gur RC.

Cognitive assessment of astronauts.

In: Bor B, Eriksen C,  Georgemiller, RJ, Gray, AL, eds. Handbook of Aviation Neuropsychology: A Practical Guide for the Clinician. Newburyport, MA: Hogrefe Publishing Corporation, 2025. p. 304.

https://www.hogrefe.com/us/shop/handbook-of-aviation-neuropsychology-98523.html

2

Vafapour H, Rafiepour P, Moradgholi J, Mortazavi S.

Evaluating the biological impact of shelters on astronaut health during different solar particle events: A Geant4-DNA simulation study.

Radiat Environ Biophys. 2025 Jan 28.

https://pubmed.ncbi.nlm.nih.gov/39873783

Note: From the abstract: “Mechanistic Monte Carlo simulations have proven invaluable in tackling complex challenges in radiobiology, for example for protecting astronauts from solar particle events (SPEs) during deep space missions which remains an underexplored area. In this study, the Geant4-DNA Monte Carlo code was used to assess the DNA damage caused by SPEs and evaluate the protective effectiveness of a multilayer shelter.”

3

Cheng L, Li Y, Yan J.

Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems.

Life Sci Space Res (Amst). 2025 Feb;44;143-53. Review.

https://pubmed.ncbi.nlm.nih.gov/39864907

4

Dachev T, Carlucci P, Cairo F, Tomov B, Matviichuk Y, Dimitrov P, Mitev M, Jordanova M, Paciucci L.

Space radiation measured during first-ever commercial suborbital mission on Virgin Galactic SpaceShipTwo Unity on 29 June 2023.

Life Sci Space Res (Amst). 2025 Feb;44:126-33.

https://pubmed.ncbi.nlm.nih.gov/39864905

5

Kumar R, Waisberg E, Ong J, Chima K, Amiri D, Tavakkoli A.

Optimizing autonomous artificial intelligence diagnostics for neuro-ocular health in space missions.

Life Sci Space Res (Amst). 2025 Feb;44:64-6. Review.

https://pubmed.ncbi.nlm.nih.gov/39864913

Note: This article is an opinion paper.

6

Marais AAT, Baranowski RW, Braun JL, Hockey BL, Fajardo VA.

Targeting GSK3 to attenuate spaceflight-induced SERCA dysfunction: Lessons from hindlimb-suspended mice.

Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167694.

https://pubmed.ncbi.nlm.nih.gov/39864669

7

Sivasubramanian N, Mumbrekar KD, Prabhu S.

Ferroptosis in space: How microgravity alters iron homeostasis.

Acta Astronaut. 2025 Apr;229:512-22. Review.

https://doi.org/10.1016/j.actaastro.2025.01.049

Note: From the abstract: “As humanity ventures into space, understanding the effects of microgravity on fundamental cellular, molecular, and physiological processes is essential. Research in this area not only addresses the challenges faced during space exploration but also has the potential to lead to novel discoveries. Microgravity research in the field of biological sciences has gained significant importance as astronauts, cosmonauts, and taikonauts experience various pathological conditions while living under gravity levels vastly different from that on Earth. This review explores insights drawn from space missions and ground-based microgravity simulation models, highlighting changes in iron utilization, storage, transport, recycling, redox signaling, and oxidative stress under microgravity conditions.”

8

Wang X, Yi F, Zou C, Yan Q, Bashir MH, Ahmed W, Mahmood SU, Wu J, Ali S.

Exposure to spaceflight enhances the virulence of Purpureocillium lilacinum against Tetranychus cinnabarinus: Modulation of the host’s enzyme activities and microbiome.

Arch Microbiol. 2025 Jan 24;207(2):43.

https://pubmed.ncbi.nlm.nih.gov/39853408

9

Diamond M, Leon GR, de León P.

Mars mission communication delays and impact on mission controller performance, workload, and stress.

Aerosp Med Hum Perform. 2025 Jan;96(1):67-70.

https://pubmed.ncbi.nlm.nih.gov/39853287

10

Hurova A, Becker M, Becu N.

Gamification in space law: A strategy to navigate the growing landscape.

Acta Astronaut. 2025 Jan 28. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2025.01.054

Note: From the abstract: “This paper presents a comprehensive assessment of the feasibility of utilizing gamification to analyze problem issues surrounding space sustainability. It examines the psychological impact of gamification on behavior patterns and explores various approaches to game creation based on the level of abstraction.”

11

Lyu Q, Zhao D, Liu J, Zhang Y, Wang Q, Wang X, Chen J, Chi Y, Li P, Cai G, Zhang L, Ma J, Chen X.

Simulated microgravity predisposes kidney to injury through promoting intrarenal artery remodeling.

Faseb j. 2025 Jan 28;39(2):e70353.

https://pubmed.ncbi.nlm.nih.gov/39874067

Note: Hindlimb unloading study.

12

Yakubets DA, Buravkova LB.

Transcriptomic shifts in multipotent mesenchymal stromal cells during microgravity simulation.

Dokl Biochem Biophys. 2025 Jan 22. Online ahead of print.

https://pubmed.ncbi.nlm.nih.gov/39847297

13

Li Y, Bansal S, Singh B, Jayatilake MM, Klotzbier W, Boerma M, Lee MH, Hack J, Iwamoto KS, Schaue D, Cheema AK.

Distinct urinary metabolite signatures mirror in vivo oxidative stress-related radiation responses in mice.

Antioxidants (Basel). 2024 Dec 27;14(1):24.

https://pubmed.ncbi.nlm.nih.gov/39857358

Note: This article is part of Research Topic “Radiation-Induced Oxidative Stress and the Role of Antioxidants in the FLASH Effect” (https://www.mdpi.com/journal/antioxidants/special_issues/Y519U3D4C6). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

14

Jia J, Wang L, Zhou Y, Zhang P, Chen X.

Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs.

Front Physiol. 2024 Jan 7;15:1501957. Review.

https://pubmed.ncbi.nlm.nih.gov/39844898

Note: This article may be obtained online without charge.

15

Wang Y, Li X, Li N, Du J, Qin X, Sun X, Wang Y, Li C.

Integrated proteomic and metabolomic analysis of muscle atrophy induced by hindlimb unloading.

Biomolecules. 2024 Dec 26;15(1):14.

https://pubmed.ncbi.nlm.nih.gov/39858409

Note: This article is part of Section “Bioinformatics and Systems Biology” (https://www.mdpi.com/journal/biomolecules/sections/bsb) and may be obtained online without charge.

16

Xu L, Zhang L, Sun Q, Zhang X, Zhang J, Zhao X, Hu Z, Zhang S, Shi F.

Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m⁶

A regulation.

Cell Mol Life Sci. 2025 Jan 23;82:60.

https://pubmed.ncbi.nlm.nih.gov/39849105

17

Casso-Chapa B, Vazquez González NA, Le N-T, Palaskas NL, Nead KT, Eutsey LP, Samanthapudi VSK, Osborn AM, Lee J, Mejia G, Hoang O, Lin SH, Deswal A, Herrmann J, Wang G, Kirkland JL, Krishnan S, Wehrens XHT, Chini EN, Yusuf SW, Iliescu CA, Jain A, Burks JK, Seeley E, Lorenzi PL, Chau KM, Ostos Mendoza KC, Grumbach IM, Brookes PS, Hanssen NMJ, de Winther MPJ, Yvan-Charvet L, Kotla S, Schadler K, Abe J.

Reevaluating anti-inflammatory therapy: Targeting senescence to balance anti-cancer efficacy and vascular disease.

Arterioscler Thromb Vasc Biol. 2025 Jan 16. Online ahead of print.

https://doi.org/10.1161/ATVBAHA.124.319870

18

Vidal E, Simonson R.

Non-invasive ventilation as a pre-oxygenation strategy during in-flight rapid sequence intubation: A case report.

Prehosp Emerg Care. 2025 Jan 24:1-8.

https://pubmed.ncbi.nlm.nih.gov/39853165

19

Vigo DE, Tuerlinckx F, Scaramal M, Baptista RR, Bersenev E, Van den Bergh O, Aubert AE.

Infradian cardiovascular rhythms and between subject cardiovascular coupling in Mars 500 prolonged confinement study.

Acta Astronaut. 2025 Jan 27. Online ahead of print.

https://doi.org/10.1016/j.actaastro.2025.01.060

spaceline, ISS, space biology, space medicine, astrobiology, microgravity, space life science,