Microfluidic Chip Archives - Astrobiology

Lab-on-chip Technologies For Space Research -- NASA

AI - Data - Apps - Cybernetics, Astropharmacy / Biotechnology, Biophysics, Biosignatures & Paleobiology, Commercial & Private Sector, Cubesats and smallsats, Exploration Gear & Tech, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Microgravity, Missions & Hardware, Nanotechnology & SynBio, Sample Return, Space Life Science, Space Stations, Status Report, Tricorders & Sensors

Lab-on-chip Technologies For Space Research — Current Trends and Prospects

by Keith CowingSeptember 30, 2024October 16, 2024

The in-depth analysis concerning application of microfluidic instruments for space biology research is presented.

OOC setup for cell cultivation under microgravity conditions: (A) image of microgravity simulator (dimensions of frame are 40 cm × 40 cm × 40 cm) combined with pressure-driven OOC cultivation setup adapted for continuous rotation; (B) image of microfluidic chip (dimensions are 4.9 cm × 3 cm and total height 6 mm) with bottom channel filled with blue dye and top channel filled with red dye. -- Micromachines

Commercial & Private Sector, Microbiology & Virology, Microgravity, Nanotechnology & SynBio, Space Life Science, Space Physiology & Medicine, Space Stations, Status Report

Offworld Bioscience: Development of Organ-on-a-Chip System with Continuous Flow in Simulated Microgravity

by Keith CowingJuly 16, 2024July 7, 2024

Organ-on-a-chip (OOC) is an innovative microfluidic device mimicking the structure and functionality of real tissue. OOCs typically involve cell culture with microfluidics to emulate the biological forces of different organ […]

Engineering model of the SHERLOC instrument undergoing tests in the laboratory. The Scanning Habitable Environments with Raman & Luminescence for Organics & Chemicals (SHERLOC) is an arm-mounted, Deep UV (DUV) resonance Raman and fluorescence spectrometer utilizing a 248.6-nm DUV laser and

Analog Studies, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Exploration Gear & Tech, Imaging & Spectroscopy, Missions & Hardware, Status Report, Tricorders & Sensors

Tricorder Tech: Developing a Microfluidic Device to Perform Surface-Enhanced Raman Spectroscopy Analysis in Future Astrobiology Missions

by Keith CowingJuly 6, 2024July 6, 2024

The main advantage of Raman spectroscopy over competing analytical instruments used in robotic planetary missions is the capability to identify both organic and inorganic molecules.

Graphical Abstract -- Life

Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Origin & Evolution of Life, Status Report

Microfluidics-Based Drying–Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions

by Keith CowingApril 30, 2024April 30, 2024

Drying–wetting cycles play a crucial role in the investigation of the origin of life as processes that both concentrate and induce the supramolecular assembly and polymerization of biomolecular building blocks, […]

The height of the chambers is 50 μm, thus confining the cells in a monolayer. Each inlet is a 50 μL reservoir and the chambers have the following dimensions: 5 mm (length) × 1 mm (width) × 50 μm (height). An immunostaining of a 10-days-old hippocampal neuronal network is also shown. The following dye and primary antibodies were used: DAPI (nucleus) in blue, MAP2 (Microtubule-associated protein 2, showing neurons) in green and GFAP (Glial Fibrillary Acidic Protein, showing astrocytes) in red. Scale bar is 150 μm. -- npj Microgravity

Commercial & Private Sector, Microgravity, Nanotechnology & SynBio, Space Life Science, Space Stations, Status Report

Influence of Microgravity on Spontaneous Calcium Activity of Primary Hippocampal Neurons Grown in Microfluidic Chips

by Keith CowingFebruary 27, 2024February 27, 2024

The influence of variations of gravity, either hypergravity or microgravity, on the brain of astronauts is a major concern for long journeys in space, to the Moon or to Mars, […]