[University of Nottingham] The Earth’s magnetic field may influence how cells produce energy, physical performance and even lifespan, according to new research from the University of Nottingham.
Metabolism
Posted inOrigin & Evolution of Life
Prebiotic Peptide Formation Triggered By Urea-rich Warm Little Ponds On Early Earth
[Bioorganic Chemistry]. In the study of the origin of life, the polymerization of amino acids into peptides in water faces significant thermodynamic barriers, often referred to as the “water problem.”
Posted inOrigin & Evolution of Life
Structure Of An RNA polymerase Ribozyme Replication Complex
[biorxiv.org] Life began with the emergence of a molecule that could replicate its own genetic material, a task plausibly mediated by an RNA-dependent RNA polymerase ribozyme.
Posted inBiochemistry & Organic Chemistry
Chemically Modified Sugars As Multifunctional Precursors For Direct, Template-Free Synthesis Of Nanoporous Carbonaceous Materials
[JACS] Carbonaceous solids with pores in the nanometer domain are of great technological importance owing to their amenability to sorption/separation, catalysis, and electrochemical applications.
![Distribution and protein structures of ancestral energy conservation enzymes in bacteria and archaea. For escape as free-living cells, metabolism had to achieve the state of a balanced stoichiometric reaction145, called redox balance in physiology, and the exergonic reactions of electron transfer from H2 to CO2 needed to be coupled to the pumping of ions from the inside of the cell to the outside (chemiosmotic coupling), as in modern cells. Prior to the coupling of CO2 reduction to ion pumping, the natural pH gradient provided by serpentinizing systems (pH 9–11, vs. sea water (pH 6.5146) was harnessable with the help of simple, abiotically synthesized hydrophobics147,148 such as fatty acids, which were recently shown to support the ATP-synthesizing function of a rotor-stator ATPase149. -- [q-bio.PE]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/08/Intermediate.png?resize=1200%2C721&ssl=1)
Posted inOrigin & Evolution of Life
Intermediate Stages In The Origin Of Metabolism At A Phosphorylating Hydrothermal Vent
[q-bio.PE] The origin of life required the emergence of metabolism, an autocatalytic network of enzymatic reactions that synthesize amino acids, nucleotides and cofactors. At the origin of metabolism there were […]
![Bold black letters illustrate amino acids that are deduced as early by the approach, while red letters indicate late additions to the alphabet according to the approach (C* implies possible prebiotic synthesis under specific and narrow conditions [4]). Regular black letters represent amino acids that have not been resolved as either early or late by the approach. LUCA: last universal common ancestor; LECA: last eukaryotic common ancestor; rTCA: tricarboxylic acid cycle. -- Trends in Genetics](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/08/Reconstructing.png?resize=1200%2C720&ssl=1)
Posted inGenomics, Proteomics, Bioinformatics
Reconstructing Ancient Protein Alphabets: What Can We Truly Infer?
[Trends in Genetics] The canonical amino acid alphabet has remained remarkably stable since life’s early stages, yet the factors that shaped its emergence remain debated. Early views emphasized prebiotic availability […]
![Physical and chemical gradients predicted to dictate habitability across depth in the martian subsurface. These include (1) constraints on water; although water activity (aw) gradients are not yet known for Mars, predicted liquid brine stability depends on primary ionic composition with perchlorate-rich brines transitioning into chloride- and sulfate-enriched brines with depth and temperature (Chevrier and Slank, 2024; Stevens and Cockell, 2023). It is important to note that porosity is expected to decrease with depth, which may also influence water availability, with any potential brines increasingly localized to pore spaces and fractures (Michalski et al., 2018). (2) Surface radiation exposure is expected to subside to lower background radionuclide decay around 3–5 m depth. (3) If liquid water is present at depth, chemotrophic microbial communities could utilize the products of water–rock interaction including inorganic electron donors/acceptors and simple abiotic organics. Image created using biorender.com.-- [Astrobiology (Journal)]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/08/Life-Detection.png?resize=1200%2C719&ssl=1)
Posted inMars
Life Detection In The Martian Subsurface: Advancements In Microbial Metabolic Research Under Mars Laboratory And Field-Analog Conditions Since Viking
[Astrobiology (Journal)] Following the Viking experiments in 1976, many of the original inferences of biological metabolism have been replicated via abiotic mechanisms we now know are plausible on Mars’ surface.
Posted inOrigin & Evolution of Life
Flavin Cycling Under Prebiotic Conditions: Bidirectional Electron Transfer And Versatility In Nickel and Iron Containing Environments
[biorxiv.org] Flavins are organic redox cofactors central to metabolism and uniquely capable of acting as extracellular electron shuttles. For life to have emerged, it must have disengaged itself from its […]
![Most theoretical work on the origin of heredity has focused on how genetic information can be maintained without mutational degradation in the absence of error-proofing systems. -- [PLOS Biology]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/Selection-For.png?resize=1200%2C715&ssl=1)
Posted inGenomics, Proteomics, Bioinformatics
Selection For Growth Drives The Emergence Of Genetic Heredity In Protocells
[PLOS Biology] A simple and parsimonious solution assumes the first gene sequences evolved inside dividing protocells, which enables selection for functional sets. But this model of information maintenance does not […]
Posted inUncategorized
Hydrothermal Origin Of Metabolic Phosphorylation
Phosphate is central to modern bioenergetics and to all theories for the origin of life. How phosphate entered metabolism is unknown, though microbial physiology and geochemical environments can provide important […]