In the search for reliable biomarker in other planetary environments such as Mars, we need molecules that are stable over geological timescales while preserving indicative information about their potential biological […]
chemrxiv.org
Mapping the Edges of Mass Spectral Prediction: Evaluation of Machine Learning EIMS Prediction for Xeno Amino Acids
Mass spectrometry is one of the most effective analytical methods for unknown compound identification. By comparing observed m/z spectra with a database of experimentally determined spectra, this process identifies compound(s) […]
Distinguishing Potential Organic Biosignatures on Ocean Worlds from Abiotic Geochemical Products using Thermodynamic Calculations
The search for life in our solar system often involves efforts to detect organic molecules, which have been found on many extraterrestrial bodies, including planets, moons, meteorites, comets, and asteroids. […]
Compositional Diversity Of Minimal Coacervates In A Nucleic Acid-peptide World
The early co-evolution of RNA and peptides is at the core of the RNA-peptide world hypothesis. Recent studies suggest that nucleotides and amino acids could have formed and polymerised non-enzymatically […]
Selection for Photocatalytic Function through Darwinian Evolution of Synthetic Self-Replicators
The onset of Darwinian evolution represents a key step in the transition of chemical systems into living ones.
Competitive Exclusion Among Self-Replicating Molecules Curtails The Tendency Of Chemistry To Diversify
The transition of chemistry into biology is poorly understood. One of the key questions in this transition is how the inherently divergent nature of chemical reactions can be curtailed, allowing […]
Distinguishing Potential Organic Biosignatures on Ocean Worlds from Abiotic Geochemical Products using Thermodynamic Calculations
The search for life in our solar system often involves efforts to detect organic molecules, which have been found on many extraterrestrial bodies, including planets, moons, meteorites, comets, and asteroids. […]
Spin-Forbidden Formation of Amide Molecules in the Interstellar Medium
In this study, two-state spin-forbidden mechanisms are proposed for the barrierless formation of amide isomers in the C2H5NO family of molecules. This family belongs to the first level of complexity […]
A Prebiotic Precursor To Life’s Phosphate Transfer System With An ATP Analogue And Histidyl Peptide Organocatalysts
Biochemistry is dependent upon enzyme catalysts accelerating key reactions. At the origin of life, prebiotic chemistry must have incorporated catalytic reactions.
Protobiotic Network Reproducers Are Compositional Attractors: Enhanced Probability for Life’s Origin
The origin of life must have involved an unlikely transition from chaotic chemistry to reproducing supramolecular structures.
