Tardigrades are microscopic animals that are renowned for their capabilities of tolerating near-complete desiccation by entering an ametabolic state called anhydrobiosis.
![AlphaFold structures of NLS-containing proteins. AlphaFold2 structures modeled from NLS-predicted proteins that had no SwissProt BLASTP hits (E-value < 1e-15). [AB] Structures for those that had a FoldSeek hit against the AlphaFold2 SwissProt database (E-value < 1E-05). The yellow and blue structures indicate the reference and the predicted H. exemplaris protein structures, respectively. [A] BV898_05254.p01 (5-hydroxytryptamine receptor 1E (AF-Q6VB83-F1-model_v4.pdb E-value = 6.22E-12, RMSD between 163 pruned atom pairs is 1.124 angstroms across all 353 pairs: 10.861) [B] Ecdysone-induced protein 78C (AF-P45447-F1-model_v4 E26 value 4.48E-08, RMSD between 84 pruned atom pairs is 1.044 angstroms; across all 391 pairs: 32.283) [C-F] Transcripts that had an IUPRED3 score of 1.0 [C] BV898_03773.p01, [D] BV898_07132.p01 [E] BV898_12866.p01 [F] BV898_18010.p01. -- biorxiv.org](https://i0.wp.com/astrobiology.com/wp-content/uploads/2024/02/Transcriptome-analysis-1.png?resize=1200%2C717&ssl=1)
Tardigrades are microscopic animals that are renowned for their capabilities of tolerating near-complete desiccation by entering an ametabolic state called anhydrobiosis.