Astronomers have detected the most promising signs yet of a possible biosignature outside the solar system, although they remain cautious.
Using data from the James Webb Space Telescope (JWST), the astronomers, led by the University of Cambridge, have detected the chemical fingerprints of dimethyl sulfide (DMS) and/or dimethyl disulfide (DMDS), in the atmosphere of the exoplanet K2-18b, which orbits its star in the habitable zone.
On Earth, DMS and DMDS are only produced by life, primarily microbial life such as marine phytoplankton. While an unknown chemical process may be the source of these molecules in K2-18bβs atmosphere, the results are the strongest evidence yet that life may exist on a planet outside our solar system.
The observations have reached the βthree-sigmaβ level of statistical significance β meaning there is a 0.3% probability that they occurred by chance. To reach the accepted classification for scientific discovery, the observations would have to cross the five-sigma threshold, meaning there would be below a 0.00006% probability they occurred by chance.
The researchers say between 16 and 24 hours of follow-up observation time with JWST may help them reach the all-important five-sigma significance. Their results are reported in The Astrophysical Journal Letters.
Earlier observations of K2-18b β which is 8.6 times as massive and 2.6 times as large as Earth, and lies 124 light years away in the constellation of Leo β identified methane and carbon dioxide in its atmosphere. This was the first time that carbon-based molecules were discovered in the atmosphere of an exoplanet in the habitable zone. Those results were consistent with predictions for a βHyceanβ planet: a habitable ocean-covered world underneath a hydrogen-rich atmosphere.
However, another, weaker signal hinted at the possibility of something else happening on K2-18b. βWe didnβt know for sure whether the signal we saw last time was due to DMS, but just the hint of it was exciting enough for us to have another look with JWST using a different instrument,β said Professor Nikku Madhusudhan from Cambridgeβs Institute of Astronomy, who led the research.
To determine the chemical composition of the atmospheres of faraway planets, astronomers analyse the light from its parent star as the planet transits, or passes in front of the star as seen from the Earth. As K2-18b transits, JWST can detect a drop in stellar brightness, and a tiny fraction of starlight passes through the planetβs atmosphere before reaching Earth. The absorption of some of the starlight in the planetβs atmosphere leaves imprints in the stellar spectrum that astronomers can piece together to determine the constituent gases of the exoplanetβs atmosphere.
The earlier, tentative, inference of DMS was made using JWSTβs NIRISS (Near-Infrared Imager and Slitless Spectrograph) and NIRSpec (Near-Infrared Spectrograph) instruments, which together cover the near-infrared (0.8-5 micron) range of wavelengths. The new, independent observation used JWSTβs MIRI (Mid-Infrared Instrument) in the mid-infrared (6-12 micron) range.
βThis is an independent line of evidence, using a different instrument than we did before and a different wavelength range of light, where there is no overlap with the previous observations,β said Madhusudhan. βThe signal came through strong and clear.β
βIt was an incredible realisation seeing the results emerge and remain consistent throughout the extensive independent analyses and robustness tests,β said co-author MΓ₯ns Holmberg, a researcher at the Space Telescope Science Institute in Baltimore, USA.
DMS and DMDS are molecules from the same chemical family, and both are predicted to be biosignatures. Both molecules have overlapping spectral features in the observed wavelength range, although further observations will help differentiate between the two molecules.
However, the concentrations of DMS and DMDS in K2-18bβs atmosphere are very different than on Earth, where they are generally below one part per billion by volume. On K2-18b, they are estimated to be thousands of times stronger – over ten parts per million.
βEarlier theoretical work had predicted that high levels of sulfur-based gases like DMS and DMDS are possible on Hycean worlds,β said Madhusudhan. βAnd now weβve observed it, in line with what was predicted. Given everything we know about this planet, a Hycean world with an ocean that is teeming with life is the scenario that best fits the data we have.β
Madhusudhan says that while the results are exciting, itβs vital to obtain more data before claiming that life has been found on another world. He says that while he is cautiously optimistic, there could be previously unknown chemical processes at work on K2-18b that may account for the observations. Working with colleagues, he is hoping to conduct further theoretical and experimental work to determine whether DMS and DMDS can be produced non-biologically at the level currently inferred.

Transmission spectrum of the habitable zone exoplanet K2-18 b using the JWST MIRI spectrograph. Credit: A. Smith, N. Madhusudhan
βThe inference of these biosignature molecules poses profound questions concerning the processes that might be producing themβ said co-author Subhajit Sarkar of Cardiff University.
βOur work is the starting point for all the investigations that are now needed to confirm and understand the implications of these exciting findings,β said co-author Savvas Constantinou, also from Cambridgeβs Institute of Astronomy.
βItβs important that weβre deeply sceptical of our own results, because itβs only by testing and testing again that we will be able to reach the point where weβre confident in them,β Madhusudhan said. βThatβs how science has to work.β
While he is not yet claiming a definitive discovery, Madhusudhan says that with powerful tools like JWST and future planned telescopes, humanity is taking new steps toward answering that most essential of questions: are we alone?
βDecades from now, we may look back at this point in time and recognise it was when the living universe came within reach,β said Madhusudhan. βThis could be the tipping point, where suddenly the fundamental question of whether weβre alone in the universe is one weβre capable of answering.β
The James Webb Space Telescope is a collaboration between NASA, ESA and the Canadian Space Agency (CSA). The research is supported by a UK Research and Innovation (UKRI) Frontier Research Grant.
To learn more about Hycean worlds, visit hycean.group.cam.ac.uk.
Reference:
Nikku Madhusudhan et al. βNew Constraints on DMS and DMDS in the Atmosphere of K2-18b from JWST MIRI.β The Astrophysical Journal Letters (2025). DOI: 10.3847/2041-8213/adc1c8 Open access
Astrobiology, Astrochemistry,
