NASA Spaceline Current Awareness List #1,132 17 January 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Puukila S, Alwood JS, Christenson LK, Ronca AE, Steller JG.Women’s health in spaceflight.In: Krittanawong C, editor. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press; 2025. p. 137-50.Note: This book chapter appeared in last week’s list in the “Other” section so is appearing again this week in the “NASA” section.
   
   Funding: J.S. Alwood and A.E. Ronca are affiliated with NASA Ames Research Center.
2. Kumar K, Moon BH, Kumar S, Angdisen J, Kallakury BVS, Fornace AJ Jr, Suman S.Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc^1638N/+ miceAging (Albany NY). 2025 Jan 8;16.PIs: A.J. Fornace Jr, S. SumanNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.955
   
   Funding: “The funding provided by The National Aeronautics and Space Administration (NASA) [Grant # NNX15A121G, 80NSSC19K1649 and 80NSSC24K0287] allowed us to secure the necessary resources, access research facilities, and conduct this research. The authors also used Lombardi Comprehensive Cancer (LCCC) Shared Resources, which is partially supported by National Cancer Institute (NCI) [Grant # P30CA051008].”
3. Bell ST, Anderson SR, Roma PG, Landon LB, Dev SI.Social support from different sources and its relationship with stress in spaceflight analog environments.Front Psychol. 2025 Jan 15;15:1350630.PI: P.G. RomaNote: This article is part of Research Topic “Optimizing Psychosocial Work Environments and Experiences for People Working in Isolated, Confined, and/or Extreme Conditions” (https://www.frontiersin.org/research-topics/38053/optimizing-psychosocial-work-environments-and-experiences-for-people-working-in-isolated-confined-andor-extreme-conditions/overview). The Special Issue also includes an article from previous Current Awareness List #1,098 https://doi.org/10.3389/fpsyg.2024.1348119. This article may be obtained online without charge.
   
   Journal Impact Factor: 2.6
   
   Funding: “Research was funded by the National Aeronautics and Space Administration (NASA) directed research projects to the Behavioral Health and Performance Laboratory: Human Factors and Behavioral Performance – Exploration Measures [HFPB-EM] in HERA; Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in Nezemnyy Eksperimental’nyy Kompleks (NEK); and the HFBP-EM Harmonization Project. PR was supported in part by the NASA grants NNX15AK76A and NNX13AB39G. SA, LL, PR, and SD were supported by KBR’s Human Health and Performance Contract NNJ15HK11B through NASA.”
4. Käosaar A, Burke CS.The effect of challenge characteristics on teamwork and affective states in ICE [Isolated, Confined, and Extreme].Group & Organization Management. 2025 Jan6;10596011241304132. Online ahead of print.Journal Impact Factor: 4.0
   
   Funding: Dr. Käosaar has been awarded two personal NASA grants. Dr. Burke has been funded by NASA.

Other papers of interest:

1. Bragina JV, Danilenkova LV, Kamysheva EA, Goncharova AA, Fedotov SA, Larina ON, Burlakova AA, Besedina NG.Behavioral changes in Drosophila males after travel to International Space Station. Part II. larvae vs. imago.Acta Astronautica. 2025 Jan 13. Online ahead of print.Note: ISS results.
2. Babocs D, Barnhart H, Fife C, Melin MM.The lymphatic system in spaceflight: The known, unknown, and theoretical.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press. 2025. p. 537-61.
3. Carr J, Ainslie PN, Day T.Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long-duration space travel.Exp Physiol. 2025 Jan 7. Review. Online ahead of print.Note: This article may be obtained online without charge.
4. Ichimura S, Yamashiki YA.Assessment of the physical and psychological aspects of the current life support system on the International Space Station for sustainable space exploration.Front Space Technol. 2025 Jan 14;5:1461389.Note: This article is part of Research Topic “Next Generation of Materials for Space Applications” (https://www.frontiersin.org/research-topics/55679/next-generation-of-materials-for-space-applications) and may be obtained online without charge.
5. Smith L.Mental health in spaceflight.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press. 2025. p. 445-56.
6. Stukenborg J-B, Mitchell RT, Verratti V, Benotmane MA, Chuva de Sousa Lopes SM, Jain V.Sex-specific differences in the adaptation to the spaceflight of mammals.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press. 2025. p. 207-28.
7. Kuang Q, He C, Huang H, Jiang H.Multi-omic analysis on the molecular mechanisms of rapid growth in ‘Deqin’ alfalfa after space mutagenesis.BMC Plant Biol. 2025 Jan 9;25(1):34.Note: From the abstract: “Space-induced plant mutagenesis, driven by cosmic radiation, offers a promising approach for the selective breeding of new plant varieties. By leveraging the unique environment of outer space, we successfully induced mutagenesis in ‘Deqin’ alfalfa and obtained a fast-growing mutant. However, the molecular mechanisms underlying its rapid growth remain poorly unexplored.” This article may be obtained online without charge.
8. Nezami A.Space psychology: A comprehensive approach to the future of astronaut wellbeing.Front Virtual Real. 2025 Jan 3;5:1446796.Note: This article is a perspective and part of Research Topic “Human Behavior in Extreme Conditions: Novel Approaches and Technologies” (https://www.frontiersin.org/research-topics/66898/human-behavior-in-extreme-conditions-novel-approaches-and-technologies) and may be obtained online without charge.
9. Chomienne L, Sainton P, Sarlegna FR, Bringoux L.Hypergravity is more challenging than microgravity for the human sensorimotor system.npj Microgravity. 2025 Jan 10;11:2.Note: This article may be obtained online without charge.
10. De Francesco S, Le Disquet I, Pereda-Loth V, Tisseyre L, De Pascale S, Amitrano C, Carnero Diaz E, De Micco V.Combined effects of microgravity and chronic low-dose gamma radiation on Brassica rapa microgreens.Plants (Basel). 2024 Dec 28;14(1):64.Note: From the abstract: Plants in space face unique challenges, including chronic ionizing radiation and reduced gravity, which affect their growth and functionality. Understanding these impacts is essential to determine the cultivation conditions and protective shielding needs in future space greenhouses. While certain doses of ionizing radiation may enhance crop yield and quality, providing “functional food” rich in bioactive compounds, to support astronaut health, the combined effects of radiation and reduced gravity are still unclear, with potential additive, synergistic, or antagonistic interactions. This paper investigates the combined effect of chronic ionizing radiation and reduced gravity on Brassica rapa seed germination and microgreens growth. This article is part of Section “Plant Response to Abiotic Stress and Climate Change” (https://www.mdpi.com/journal/plants/sections/plant_response_abiotic_stress) and may be obtained online without charge.
11. Grinberg M, Vodeneev V.The role of signaling systems of plant in responding to key astrophysical factors: Increased ionizing radiation, near-null magnetic field and microgravity.Planta. 2025 Jan 11;261(2):31. Review.
12. Kokkinos V, Koupparis AM, Fekete T, Privman E, Avin O, Almagor O, Shriki O, Hadanny A.The posterior dominant rhythm remains within normal limits in the microgravity environment.Brain Sci. 2024 Nov 27;14(12):1194.Note: From the abstract: “Three crew members during the 16-day AXIOM-1 mission to the International Space Station (ISS), underwent scalp EEG recordings before, during, and after the mission by means of a dry-electrode self-donning headgear designed to support long-term EEG recordings in space.” From the abstract: “Three crew members during the 16-day AXIOM-1 mission to the International Space Station (ISS), underwent scalp EEG recordings before, during, and after the mission by means of a dry-electrode self-donning headgear designed to support long-term EEG recordings in space.” This article is part of Special Issue “Studies in Human Performance and Experience: Neuroscience and Functional Brain Imaging: 2nd Edition” (https://www.mdpi.com/journal/brainsci/special_issues/UQ3471339Y) and may be obtained online without charge.
13. Liu Y, Cao X, Zhou Q, Deng C, Yang Y, Huang D, Luo H, Zhang S, Li Y, Xu J, Chen H.Mechanisms and countermeasures for muscle atrophy in microgravity.Cells. 2024 Dec 20;13(24):2120. Review.Note: This article may be obtained online without charge.
14. Albadawi EA.Structural and functional changes in the hippocampus induced by environmental exposures.Neurosciences (Riyadh). 2025 Jan;30(1):5-19. Review.Note: From the abstract: “The hippocampus, noted as (HC), plays a crucial role in the processes of learning, memory formation, and spatial navigation. Recent research reveals that this brain region can undergo structural and functional changes due to environmental exposures, including stress, noise pollution, sleep deprivation, and microgravity. This review synthesizes findings from animal and human studies, emphasizing the HC’s plasticity in response to these factors.”
15. Ogneva IV, Zhdankina YS, Gogichaeva KK, Malkov AA, Biryukov NS.The motility of mouse spermatozoa changes differentially after 30-minute exposure under simulating weightlessness and hypergravity.Int J Mol Sci. 2024 Dec 18;25(24):13561.Note: A 3D clinostat was used in this study. This article is part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment (3rd Edition)” (https://www.mdpi.com/journal/ijms/special_issues/S0P509B1W1). The Special Issue also includes articles from previous Current Awareness Lists #1,107 https://doi.org/10.3390/ijms25126484 and #1,113 https://doi.org/10.3390/ijms25158316. This article may be obtained online without charge.
16. Tansley J, Miché N, Bernagozzi M, Cahill S, Georgoulas A, Santin M, Forss R.Gravity effects on lower limb perfusion observed during a series of parabolic flights.Acta Astronaut. 2025 Jan 10. Online ahead of print.
17. Bai L, Li J, Li G, Zhou D, Su J, Liu C.Skeletal interoception and prospective application in biomaterials for bone regeneration.Bone Res. 2025 Jan 2;13:1.
18. Kermorgant M, Varenne F, Pavy-Le Traon A, Geeraerts T, Barioulet L, Fournié P, Billette de Villemeur R, Bareille MP, Beck A, Golemis A, Antunes I, Gauquelin-Koch G, Soler V, Quintyn JC.The effects of antioxidant cocktail on ophthalmological changes induced by a 60-day head-down bedrest in a randomized trial.Life (Basel). 2024 Dec 4;14(12):1598.Note: This article is a perspective and part of Special Issue “Space Medicine Ophthalmology: Insights from Molecular Observations to the Clinical Management of Ocular Risks in Microgravity” (https://www.mdpi.com/journal/life/special_issues/416F742D6M). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
19. Ren W, Liu L, Liang J, Zhang P, Wu D, Zhang Z.Effects of short time -30° head-down tilt on time perception.Perception. 2025 Jan 13;3010066241311831. Online ahead of print.

Astrobiology, space biology, space medicine, microgravity,