NASA Spaceline Current Awareness List #1,170 17 October 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Brunstetter TJ, Mason SS, Osborne S, Young M, Oswald T, Gibson CR, Patel N, Mader TH, Lee AG, Brown DM, Tsung A, Tarver W.Predicting spaceflight-associated neuro-ocular syndrome in International Space Station astronauts.JAMA Ophthalmol. 2025 Oct 9. Online ahead of print.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 6.7
   
   Funding: T.J. Brunstetter, M. Young, and W. Tarver are affiliated with NASA Johnson Space Center.
2. Winer DA, Du H, Kim J, Chang V, Burke M, Winer S, Costes SV, Frippiat JP, Sams C, Paul AM, Wu H, Ullrich O, Baatout S, Beheshti A, Mason CE, Choukér A, Crucian BE.Astroimmunology: The effects of spaceflight and its associated stressors on the immune system.Nat Rev Immunol. 2025 Oct 16. Review. Online ahead of print.PI: C.E. MasonNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 60.9
   
   Funding: “…This work is also supported by ESA/BELSPO/PRODEX IMPULSE contract CO-90-11-2801-04 (S.B.). The authors also acknowledge support by the NASA Human Research Program, Human Health and Countermeasures Element, the Centre National d’Etudes Spatiales (CNES, the French Space Agency). C.E.M. thanks the WorldQuant and GI Research Foundation, NASA (NNX14AH50G, NNX17AB26G, NNH18ZTT001N-FG2, 80NSSC22K0254, 80NSSC23K0832, 80NSSC24K0728, 24-24NSCOR_2-0008, 24-24FLAG_2-0099 and 22-22SBR_2-0104), the National Institutes of Health (R01ES032638, P01CA272295 and U54AG089334) and the LLS (MCL7001-18, LLS 9238-16, 7029-23). J.K. was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF), funded by the Ministry of Education(RS-2023-00241586). …”
3. Karouia F, de Oliveira LC, Hameed A, Simpson A, Singh N, Rekha PD, Mason CE, Venkateswaran K.Genomic characterization of Microbacterium meiriae sp. nov., a novel bacterium isolated from the International Space Station.Sci Rep. 2025 Oct 14;15:35770.PI: K. VenkateswaranNote: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.9
   
   Funding: “CEM thanks the Scientific Computing Unit (SCU) at WCM, the WorldQuant Foundation, NASA (NNX14AH50G, NNX17AB26G, NNH18ZTT001N-FG2, 80NSSC22K0254, NNX16AO69A), the National Institutes of Health (R01MH117406), and the LLS (MCL7001- 18, LLS 9238-16) © 2025 California Institute of Technology, Government sponsorship acknowledged.” “…This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also supported NKS and AS.”
4. Chauhan V, Grybas VS, Hoopfer D, Higginson C, Ainsbury EA, Azimzadeh O, Beheshti A, Blattnig S, Boerma M, Costes SV, Doty S, Adam-Guillermin C, Hamada N, Hinton P, Huff JL, Reynolds R, Wilkins RC, Wood S, Yauk CL.Adverse outcome pathways applied to space radiation research.Environ Mol Mutagen. 2025 Oct 8. Review. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.3
   
   Funding: “The work has been funded partially by the Canadian Space Agency, Health Canada Solutions Fund, and a Genomics Research and Development Initiative. Professor Ainsbury is a member of the Health Protection Research Unit in Chemical and Radiation Threats and Hazards, a partnership between UK Health Security Agency and Imperial College London, which is funded by the National Institute for Health Research (NIHR). Dr. Yauk (University of Ottawa) acknowledges that her contributions were undertaken in part thanks to funding from the Canada Research Chairs program. Drs. Huff and Blattnig are supported by the NASA Human Research Program, Space Operations Mission Directorate.”
5. Dixon C, Massa GD, Jones SB.Optimizing an on-demand passive fertigation system for microgravity.Gravit Space Res. 2025 Oct 9;13(1):90-102.Note: From the abstract: “Plant production in microgravity is essential for sustaining astronauts long-term space missions. However, previous containerized plant cultivations in space has yielded inconsistent results, largely due to challenges in understanding the hydraulic properties of porous media, particularly water retention characteristics (WRCs) and hydraulic potential (H) under microgravity. This study addresses the issue of over-fertigation in the root zone, a persistent challenge in past space-based systems. We propose an on-demand passive fertigation system, regulated by a check valve-controlled H and tailored to the WRCs of the porous medium.” This article may be obtained online without charge.
   
   Journal Impact Factor: 0.2
   
   Funding: “This study is based upon work supported by the National Aeronautics and Space Administration (NASA) under grant Nos. 80NSSC20K1411 and 80NSSC23K0755 issued through Appendix C: Development of Microgravity Food Production: Plant Watering, Volume Management and Novel Plant Research on the International Space Station (NNH18ZTT001N-PT).”
6. Gonzalez TJ, Boothby TC.Properties governing dry-state stability of RNA in amorphous sugar formulations.Commun Mater. 2025 Jul 1;6:129Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 9.6
   
   Funding: NASA Grant #80NSSC20M0113.
7. Poignant F, Levrague V, Roccia M, Tran NH, Incerti S, Beuve M, Testa E, Plante I, Rahmanian S, Delorme R.DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations.Life Sci Space Res. 2025 Oct 12. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.8
   
   Funding: “This work was supported by the NASA Langley Research Center contract 80LARC23DA003 (F.P., S.R.); the NASA Human Health and Performance contract NNJ15HK11B (I.P.), the Centre National de Recherche Scientifique (CNRS) (R.D.), the LabEx PRIMES (ANR-11-LABX-0063) within the program Investissements d’Avenir operated by the French National Research Agency (ANR) (M.R., V.L.) and the ITMO Cancer AVIESAN within the framework of Cancer 2020 (V.L.).”

Other papers of interest:

1. Shahzad Z, Rafay RH, Bala N, Dogan YE, Alli AA.The heart in space: Effects of microgravity on different cell types and their functions in the cardiovascular system.Biomedicines. 2025 Sep 24;13(10):2336. Review.Note: This article is part of Special Section “New Advances in Cardiovascular Drugs: In Memory of Professor Akira Endo” (https://www.mdpi.com/journal/biomedicines/special_issues/9M199QUULI) and may be obtained online without charge.
2. Tomaraei SN, Ahmed M, Nami M.Circadian disruption in astronauts: Causes, molecular mechanisms, and neurocognitive consequences.Chronobiol Int. 2025 Oct 15;1-18. Review.
3. Izcan S, Pushparaj N, Williams PM, Cappelletti C.Teleoperated astropharmaceutical payload for long-duration space missions: Project VITA!Acta Astronaut. 2026 Jan;238:187-201.
4. Ho PL, Tran SH, Song D-G, Lee JI, Kim HS, Kwon HC, Kang K.Caenorhabditis elegans: A tiny model animal for space biology research.Appl Biol Chem. 2025 Oct 2;68(1):70.Note: This article may be obtained online without charge.
5. Cai H, Jia R, Chen H, Wu Y, Qin Y, Si S, Zhu L, Lou X, Li X.Simulated microgravity affects immune reaction to infection through altering lymphocyte differentiation, cytokine secretion, and macrophage polarization.Life Sci Space Res. 2025 Oct 10. Online ahead of print.Note: Hindlimb unloading study.
6. Chen F, Khan MN, Xie M, Zhang Y, Li L, Dar Farooq A, Liu J, He Q, Liu X, Jiang N.Polygonatum sibiricum polysaccharides alleviate simulated weightlessness-induced cognitive impairment by gut microbiota modulation and suppression of NLRP3/NF-κB pathways.Nutrients. 2025 Oct 5;17(19):3157.Note: Hindlimb unloading study. This article is part of Section “Carbohydrates” (https://www.mdpi.com/journal/nutrients/sections/Carbohydrates) and may be obtained online without charge.
7. Foucambert P, Hang JW, Malleret B.Exploring erythropoiesis: Aging through the lens of malaria and microgravity.Trends Parasitol. 2025 Oct 14:S1471-4922(25)00283-1. Review. Online ahead of print.Note: This article may be obtained online without charge.
8. Ismail A, Elmoselhi AB, Nada LA, Rahman B, Badran Z, Verron E.Immune and inflammatory responses in microgravity: Implications and therapeutic approaches.Drug Discov Today. 2025 Oct 11:104503. Review.
9. Rodriguez L, Fiedler L, Zou M, Giannini C, Monzer A, Vladimirtsev D, Randuch M, Yu Y, Gelová Z, Verstraeten I, Hajný J, Chen M, Tan S, Hoermayer L, Li L, Marques-Bueno MM, Quddoos Z, Molnár G, Kulich I, Jaillais Y, Friml J.ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism.Cell. 2025 Oct 2. Online ahead of print.Note: This article may be obtained online without charge.
10. Böcker J, Schmitz M-T, Hoffmann L, Bloch W, Rittweger J.Variability in individual musculoskeletal response is not increased by countermeasures during bedrest.Front Physiol. 2025 Oct 13;16:1645482.Note: This article may be obtained online without charge.
11. Yu F, Ma X, Liu Y, Wang R, Huang Z, Wang Y, Zhang J, Dong R, Qiao P-G, Zheng W, Qian L, Ren P, Wang Z.Heterogeneous and lateralized cervical vascular responses to a 7-day head-down tilt bedrest.npj Microgravity. 2025 Oct 16;11:70.Note: This article may be obtained online without charge.
12. Ge YL, Xu J, Cai Y, Zhang B, He SY, Li PJ, Bu YR, Zhang L, Yu ZB, Ma H, Liu Y, Chen XW, Xie MJ.BMAL1 modulation alleviates inflammatory responses in monocytes by targeting the Fis1-mediated mitochondrial unfolded protein response in high-altitude hypoxia.Cell Commun Signal. 2025 Oct 8;23:420.Note: This article may be obtained online without charge.
13. Lu C, Gu D, Chen H, Chen L, Chen J, Weng Y, Lin X.BM-MSCs mitigate lung injury in a rat model of decompression sickness.Cell Commun Signal. 2025 Oct 8;23:420.Note: This article may be obtained online without charge.
14. Weber BM, Panzirsch M, Singh H, Proske U.Human limb position sense measured by repositioning during changes of gravity in parabolic flight.Sci Rep. 2025 Oct 15;15:36107.Note: This article may be obtained online without charge.

astrobiology, space biology, space medicine, microgravity, ISS,