NASA Spaceline Current Awareness List #1,122 1 November 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Patel CM, Wiele SV, Kim L, Payne E, Bruno-Garcia M, Devorak A, Kaganov DE, Lau A, Guthold M, Delp MD, Crapo J, Mao XW, Willey JS.Treatment with a superoxide dismutase mimetic for joint preservation during 35 and 75 days in orbit aboard the International Space Station, and after 120 days recovery on Earth.Life Sci Space Res. 2024 Oct 28. Online ahead of print.PI: X.W. MaoNote: ISS results.
   
   Journal Impact Factor: 2.9
   
   Funding: “This work was supported by NASA Space Biology grant #NNX15AB41G, and the Milton Raben, MD Professorship in Radiation Oncology (JSW). The authors would like to acknowledge research support from the Cancer Genomics Shared Resource and the Tumor Tissue and Pathology Shared Resource Comprehensive Cancer Center of Wake Forest University NCI CCSG P30CA012197 grant. The authors would like to acknowledge the support of the Imaging and Mechanics-based Projects on Accidental Cases of Trauma (IMPACT)…”
2. Tuladhar A, Shaver JC, McGee WA, Yu K, Dorn J, Horne JL, Alhamad DW, Hagan ML, Cooley MA, Zhong R, Bollag W, Johnson M, Hamrick MW, McGee-Lawrence ME.Prkd1 regulates the formation and repair of plasma membrane disruptions (PMD) in osteocytes.Bone. 2024 Sep;186:117147.Journal Impact Factor: 3.5
   
   Funding: “Funding was received from the NSF (BMMB # 1727949), NASA (Space Biology # 80NSSC21K027), and NIH (S10 OD025177). The authors wish to thank the Augusta University Electron Microscopy and Histology Core facility for histological specimen preparation and the Augusta University Cell Imaging Core facility for assistance with imaging.”
3. Rosekind MR, Flynn-Evans EE, Czeisler CA.Fatigue in air traffic operations-Opportunities to enhance safety.Jama. 2024 Oct 28. Online ahead of printJournal Impact Factor: 63.1
   
   Funding: E.E. Flynn-Evans is affiliated with NASA Ames Research Center.
4. Hönemann JN, Hoffmann F, de Boni L, Gauger P, Mulder E, Möstl S, Heusser K, Schmitz MT, Halbach M, Laurie SS, Lee SMC, Macias BR, Jordan J, Tank J.Impact of daily lower-body negative pressure or cycling followed by venous constrictive thigh cuffs on bedrest-induced orthostatic intolerance.J Am Heart Assoc. 2024 Oct 25;e034800. Online ahead of print.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
   
   Journal Impact Factor: 6.106
   
   Funding: “This work was supported by the National Aeronautics and Space Administration and programmatic funding of the German Aerospace Center. Dr. Hönemann received funding from the German Aerospace Center and the German Federal Ministry of Economy and Technology (BMWi; 50WB1816).”
5. Schuerger AC.Synergistic interactions among vacuum, solar heating, and UV irradiation enhance the lethality of interplanetary space.Microorganisms. 2024 Sep 29;12(10):1976.Note: From the abstract: “A Planetary Atmospheric Chamber (PAC) was used to create simulations of interplanetary conditions to test the spore survival of three Bacillus spp. exposed to interacting conditions of vacuum (VAC), simulated solar heating (HEAT), and simulated solar ultraviolet irradiation (UV).” This article may be obtained online without charge.
   
   Journal Impact Factor: 4.1
   
   Funding: “Funding support for the creation of this work was provided by the National Aeronautics and Space Administration (NASA), Planetary Protection Office, NASA Headquarters, Washington, DC, USA (grant 80NSSC20K0745).”

Other papers of interest:

1. Serova AV, Zhuravleva OA, Rykova MP, Antropova EN, Markin AA.[Morphofunctional status of cosmonauts’ erythrocytes after missions to the International space station of varying durations.]Aviakosm Ekolog Med. 2024;58(4):58-65. Russian.Note: ISS results.
2. Sugimoto M, Maekawa M, Mita H, Yokobori S.Anthocyanin can improve the survival of rice seeds from solar light outside the International Space Station.Life Sci Space Res. 2024 Oct 30. Online ahead of print.Note: ISS results.
3. Barbour BN, Twardowska K, Favero N, Ghoddousi P, Hodkinson P.Biopsychosocial health considerations for astronauts in long-duration spaceflight: A narrative review.Wilderness Environ Med. 2024 Oct 29:10806032241289106. Review. Online ahead of print.Note: This article may be obtained online without charge.
4. Demir AE, Sevinc EN, Ulubay M.The effect of cosmic radiation exposure on pregnancy during a probable crewed mission to Mars.Life Sci Space Res. 2024 Oct 28. Review. Online ahead of print.
5. Fryc D, Michnik R.Intrasubject and intersubject variability of stabilography parameters in normal conditions and simulated space mission isolation.J Biomech. 2024 Nov;176:112378.Note: From the abstract: “The study provides statistical data on 10 different stabilography measurements of 18 participants performed on different days during an analog space mission (5 females and 4 males) and in normal conditions (5 females and 4 males). Descriptive statistics and interclass correlation were used to determine intra- and intersubject variability.”
6. Restier-Verlet J, Ferlazzo ML, Granzotto A, Al-Choboq J, Bellemou C, Estavoyer M, Lecomte F, Bourguignon M, Pujo-Menjouet L, Foray N.Accelerated aging effects observed in vitro after an exposure to gamma-rays delivered at very low and continuous dose-rate equivalent to 1-5 weeks in the International Space Station.Cells. 2024 Oct 15;13(20):1703.Note: This article may be obtained online without charge.
7. Wostyn P, Goddaer P.Immersive gamma music as a tool for enhancing glymphatic clearance in astronauts while improving their mental well-being.Life Sci Space Res. 2024 Oct 28. Online ahead of print.Note: This is an opinion/position paper.
8. Bonetto V, Pagano CA, Sabbatini M, Magnelli V, Donadelli M, Marengo E, Masini MA.Microgravity as a tool to investigate cancer induction in pleura mesothelial cells.Curr Issues Mol Biol. 2024 Sep 27;46(10):10896-912.Note: From the introduction: “In the present work, we investigated the induction of cancer transformation in non-malignant mesothelioma MeT-5A cells exposed to simulated microgravity conditions using a 3D-random positioning machine (3D-RPM), focusing on alterations in cytoskeletal dynamics and adhesion profiles.” This article is part of Special Issue “Advances in Molecular Pathogenesis Regulation in Cancer 2024” (https://www.mdpi.com/journal/cimb/special_issues/MZUFBY182M) and may be obtained online without charge.
9. Derobertmasure A, Toh LS, Verstuyft C, Lukic S, De Sousa Carvalho C, Couronné R, Beauvalet M, Chhun S, Boutouyrie P.Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns.Br J Clin Pharmacol. 2024 Oct 29. Online ahead of print.Note: This article may be obtained online without charge.
10. Ellena G, Fahrion J, Gupta S, Dussap CG, Mazzoli A, Leys N, Mastroleo F.Development and implementation of a simulated microgravity setup for edible cyanobacteria.npj Microgravity. 2024 Oct 25;10(1):99.Note: A random positioning machine was used in this study. This article may be obtained online without charge.
11. Galanin IV, Naryshkin AG, Skoromets TA, Sarkisian AM, Orlov IA.[Connectome and microgravity.]Aviakosm Ekolog Med. 2024;58(4):5-14. Russian.Note: From the abstract: “This paper reviews the current views on formation, development, and activity of the connectome under the influence of gravity.”
12. Kim SC, Kim MJ, Park JW, Shin YK, Jeong SY, Kim S, Ku JL.Effects of simulated microgravity on colorectal cancer organoids growth and drug response.Sci Rep. 2024 Oct 26;14(1):25526.Note: A 3D clinostat was used in this study. This article may be obtained online without charge.
13. Mei T, Chen Y, Gao Y, Zhao H, Lyu X, Lin J, Niu T, Han H, Tong Z.Formaldehyde initiates memory and motor impairments under weightlessness condition.npj Microgravity. 2024 Oct 28;10(1):100. Review.Note: This article may be obtained online without charge.
14. Ratushnyy AY.[Morphofunctional properties of mesenchymal stromal cells exposed to GDF11.]Aviakosm Ekolog Med. 2024;58(4):52-7. Russian.
15. Barkia B, Sandt V, Melnik D, Cortés-Sánchez JL, Marchal S, Baselet B, Baatout S, Sahana J, Grimm D, Wehland M, Schulz H, Infanger M, Kraus A, Krüger MThe formation of stable lung tumor spheroids during random positioning involves increased estrogen sensitivity.Biomolecules. 2024 Oct 12;14(10):1292Note: This article is part of Special Issue “Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals, and Plants” (https://www.mdpi.com/journal/biomolecules/special_issues/5JR4HV8X19). The Special Issue also includes articles from previous Current Awareness Lists #1,035 https://doi.org/10.3390/biom13020201 and https://doi.org/10.3390/biom13020189; #1,038 https://doi.org/10.3390/biom13020371; #1,084 https://doi.org/10.3390/biom14010065; #1,095 https://doi.org/10.3390/biom14040446; #1,098 https://doi.org/10.3390/biom14030327; and #1,107 https://doi.org/10.3390/biom14060682. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
16. Bjegojević B, Pušica M, Gianini G, Gligorijeviá I, Cromie S, Leva MC.Neuroergonomic attention assessment in safety-critical tasks: EEG indices and subjective metrics validation in a novel task-embedded reaction time paradigm.Brain Sci. 2024 Oct 7;14(10):1009.Note: This article is part of Special Issue “Computational Intelligence and Brain Plasticity” (https://www.mdpi.com/journal/brainsci/special_issues/548FW6TH7M) and may be obtained online without charge.
17. Ilyin VK, Solovieva ZO, Nikonorov AG, Nosovsky AM, Rykova MP, Sheblaeva AS, Guizinger OA, Lovtsevich SM, Sheblaev MV, Kraeva LA.[Changes in oral microbiocenosis under the influence of auto-probiotics based on Streptococcus salivarius in the conditions of hypobaria and cold stress.]Aviakosm Ekolog Med. 2024;58(4):66-71. Russian.
18. Lapshina TA, Emelianov YA, Bakovets DV, Dudina EA, Blaguinina EA.[Effect of premenstrual syndrome on static muscular endurance of female lower extremities.]Aviakosm Ekolog Med. 2024;58(4):58-65. Russian.
19. Li LF, Yu J, Li R, Li SS, Huang JY, Wang MD, Jiang LN, Xu JH, Wang Z.Apoptosis, mitochondrial autophagy, fission, and fusion maintain mitochondrial homeostasis in mouse liver under hindlimb unloading conditions.Int J Mol Sci. 2024 Oct 18;25(20):11196.Note: Hindlimb unloading study. This article is part of Special Issue “Mitochondrial Medicine: Pharmacological Targeting of Mitochondria in Disease 2.0” (https://www.mdpi.com/journal/ijms/special_issues/9NC6NGR3JU) and may be obtained online without charge.
20. Tikhomirova NA, Ushakova SA, Shikhov VN, Trifonov SV, Anishchenko OV, Tikhomirov AA.[Determination of the level of light saturation of wheat production activity during cultivation on solutions with the use of mineralized human exo-metabolites, as applied to HLSS.]Aviakosm Ekolog Med. 2024;58(4):84-92. Russian.Note: From the abstract: “We investigated the significance of photosynthetically active radiation (PAR) for the production activity of wheat crops cultivated on liquid products of human exometabolites mineralization as applied to hybrid life support systems (HLSS).”
21. Vilchinskaya NA, Sergeeva KV, Tyganov SA, Shenkman BS, Mirzoev TM.[Role of the mechanically activated channels in the regulation of anabolic markers in the isolated rat postural muscle in response to passive stretching.]Aviakosm Ekolog Med. 2024;58(4):44-51. Russian.

Astrobiology, space biology, space medicine, microgravity,