NASA Spaceline Current Awareness List #1,167 26 September 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Fullstone TL, Fischer LFJ, Bohmeier M, Frings-Meuthen P, Crucian BE, Rathert P.Epigenomic profiling of immune cell subtypes reveals H3K27ac-marked stress signatures after long-duration spaceflight.Sci Rep. 2025 Sep 12;15(1):32445.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.9
   
   Funding: B.E. Crucian is affiliated with NASA Johnson Space Center.
2. Miousse IR, Skinner CM, Pathak R, Sridharan V, Melnyk S, Willey J, Chancellor J, Hauer-Jensen M, Boerma M, Koturbash I.Exposure to a single dose of space-relevant proton radiation alters the intestinal one-carbon metabolism pathway and microbiome in mice.Radiat Res. 2025 Sep 24. Online ahead of print.Journal Impact Factor: 2.5
   
   Funding: “This work was supported by the National Space Biomedical Research Institute [RE03701 through NCC 9-58]; National Space and Aeronautics Administration (NASA), grants # 80JSC019N001-HHCBPSR and 19HCBPSR2-0057; Clinical and Translational Science Awards UL1TR000039 and KL2TR000063; NIGMS, grant P20 GM109005, and the Arkansas Biosciences Institute.”
3. Xu X, Blattnig S, Slaba T.A multilevel probabilistic dose response model for radiation-induced Harderian gland tumor prevalence – single beam and mixed field effects.Life Sci Space Res. 2025 Sep 17. Online ahead of print.Note: From the abstract: “In this work, a dose-response model is developed on the basis of probabilistic arguments and considers processes occurring at the cellular and tissue level that ultimately result in radiation induced tumorigenesis.”
   
   Journal Impact Factor: 2.8
   
   Funding: “This work is funded by the NASA Human Research Program under the Space Operations Mission Directorate of NASA.”
4. Knuth ND, Butts AS, Chartier GL, Landers-Ramos RQ.Association between whole-body and skeletal muscle oxygen consumption rate at rest and while ambulatory.Med Sci Sports Exerc. 2025 Oct;57(10S):799-800.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 4.0
   
   Funding: “NASA Grant NNX16AO69A; NIH grant UL1TR001857.”
5. Neofes D, Wu V, Monteleone J, Sheng T, Ortega-Reyes O, Salinas M, Hierro M, DeMaio R, Weissman AJ, Guyette FX, Gordon B, Mortreux M, Melanson K, Buysse D, Empey P, Ward-Ritacco C, Callaway CW, Flickinger KL.Changes in grip strength during 5-day metabolic reduction.Med Sci Sports Exerc. 2025 Oct;57(10S):798-9.PIs: M. Mortreux, C.W. Callaway, K.L. FlickingerNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 4.0
   
   Funding: “NASA Grant NNX16AO69A; NIH grant UL1TR001857.”

Other papers of interest:

1. Marin L, Bordin L, Sabbadin C, Ambrosini G, Andrisani A.Beyond Earth, beyond time: Preserving female fertility in space missions.J Clin Med. 2025 Aug 24;14(17):5975. Review.Note: This article is part of Special Issue “Challenges in Fertility Preservation” (https://www.mdpi.com/journal/jcm/special_issues/JA5L326WL2) and may be obtained online without charge.
2. Asrar FM, Sieber MA, Possnig C, Mukai C, Morgan AR.Physician astronauts advancing deep-space exploration.Lancet. 2025 Sep 20;406(10509):1217-8.Note: This article is a Correspondence and may be obtained online without charge.
3. Böcker J, Zange J, Gruber M, Fau G, Rawer R, Törholm S, Runge A, Rittweger J.NEX4EX – A novel exercise device enabling resistive, plyometric and sensorimotor training during deep-space missions: A case report.Exp Physiol. 2025 Sep 15. Online ahead of print.Note: This article may be obtained online without charge.
4. Goto M.Physiological changes in the cardiovascular system during spaceflight – Current countermeasures and future vision.Circ Rep. 2025 Sep 10;7(9):742-9. Review.Note: This article may be obtained online without charge.
5. Li Y, Fang W, Jiang T, Yu H, Zhao R, Zhan W, Sun Z, Li Y.Effects of dynamic lighting on neurobehavioral performance under different mental states in the working area of a space station.Ergonomics. 2025 Sep 16;1-21. Online ahead of print.
6. Neje P, Kulkarni S, Dabhekar S, Taksande B, Umekar M, Mangrulkar S.Neuroprotective and neuromodulatory role of agmatine in mitigating simulated microgravity-induced cognitive and behavioral deficits in rats.Life Sci Space Res. 2025 Sep 14. Online ahead of print.Note: Hindlimb unloading study.
7. Dev D, Batool A, Pasko Z, Bakir O, Guerra AA.Space pharmacopeia and AI: Designing a comprehensive and proactive AI healthcare management tool for short-term space missions.Acta Astronaut. 2025 Sep 25. Online ahead of print.
8. Qaisar R.From aging to space: A comparative biology of skeletal muscle degeneration.Biochim Biophys Acta Mol Basis Dis. 2026 Jan;1872(1):168058. Review.
9. de Luis M, López-Pujol J, Mota J, Merlo ME, Aacute;lvarez-Jiménez J, Aparicio JI, Bartolomé C, Ormö J, Parro LM.Gypsophytes and the use of Martian gypsum: A review of their potential for agriculture on Mars.Life Sci Space Res. 2025 Sep 25. Online ahead of print.Note: This article may be obtained online without charge.
10. Haq S, Hájek J, Barták M.Growth rate, biomass formation and physiological adjustment of terrestrial crops cultivated in Antarctic volcanic regolith: A functional simulant for lunar agriculture.Acta Astronaut. 2025 Sep 19. Online ahead of print.
11. Jain A, Jain P.Badminton in space: Assessing physical and mental well-being of astronauts during extended isolation.Acta Astronaut. 2026 Jan;238:560-7.
12. Jasemi S, Simula ER, Lin Y, Satta RR, Rubino C, Cossu A, Fais M, Noli M, Sechi LA.Immune system-tumor crosstalk under microgravity: Mechanistic insights, challenges, and translational perspectives.Cancers (Basel). 2025 Aug 23;17(17):2737. Review.Note: This article is part of Special Issue “Cancer-Therapy-Related Adverse Events (2nd Edition)” (https://www.mdpi.com/journal/cancers/special_issues/N7UDM501M0) and may be obtained online without charge.
13. Mei C, Xie G, Han Y, Peng M.Biochar derived from plant waste improves seedling growth by influencing the physical structure and nutrient content of simulated lunar soil.Acta Astronaut. 2025 Sep 15. Online ahead of print.
14. Fan Y, Li J, Han J, Xing W, Li Y, Liu Z, Zhong G, Du R, Zhao J, Sun W, Yuan X, Li Y, Yue H, Pan J, Jin X, Wang L, Ling S, Zhang L, Li Y.Dynamic changes in hindlimb motor cortex neurons during simulated weightlessness revealed by miniature 2-photon microscopy.Research (Wash D C). 2025 Sep 19;8:0877.Note: This article may be obtained online without charge.
15. Hedge ET, Bryans CG, Mastrandrea CJ, Siebenmann C, Hargens AR, Karlsson LL, Hughson RL, Linnarsson D.Exercise during artificial gravity preserves cardiorespiratory fitness but not orthostatic tolerance following 60 days of head-down bedrest (BRACE).J Appl Physiol (1985). 2025 Sep 15. Online ahead of print.Note: This article may be obtained online without charge.
16. Kobayashi K, Murakoshi Y, Kanamori K, Hidema J, Masuda G, Tanaka K, Yotsui I, Sakata Y, Taji T.UVH6 regulates osmotic and heat stress tolerance by modulating transcription.Front Plant Sci. 2025 Sep 18;16:1623563.Note: This article is part of Research Topic “Plant Stress Resistance: Unraveling the Mechanisms and Strategies for Resilience” (https://www.frontiersin.org/research-topics/69297/plant-stress-resistance-unraveling-the-mechanisms-and-strategies-for-resilience) and may be obtained online without charge.
17. Li H, Han P, Li Y, Li X, Liu Y, Wang W.Effect of hfq (host factor for RNA phase Q_β replicase) on environmental tolerance of Escherichia coli under simulated microgravity.Int J Microbiol. 2025 Sep 10;9150440.Note: From the abstract: “The SMG environment is established using the Gravite control system. This system is a multidirectional G-force generator that can simultaneously control the rotation of two axes, that is, rotate in three-dimensional space. This unique feature allows for the cancellation of accumulated gravity vectors at the center of the device, creating a 10-3 g microgravity environment similar to that of the International Space Station (ISS).”
18. Winkelbauer M, Janiak J, Windisch J, Liu H, Bulatova M, Von Witzleben M, Oliveira H, Dani S, Richter RF, L’Heureux N, Bar-Nur O, Gelinsky M, Zenobi-Wong M, Chansoria P.Prolonged cell encapsulation and gravity-independent filamented light biofabrication of muscle constructs.Adv Sci (Weinh). 2025 Sep 23:e12727. Online ahead of print.Note: This article may be obtained online without charge.
19. Yang X, Yu L, Tian Y, Yin G, Lv Q, Guo J.Ultrasound assessment of muscle atrophy during short- and medium-term head-down bedrest.Ultrasound Med Biol. 2025 Sep 11. Online ahead of print.
20. Mizera N.Investigating the expectations of the space industry stakeholders regarding space education at Polish universities.Acta Astronaut. 2025 Dec;237:1-11.
21. Moazen S, Gosselin FP, Tabiai I, Dubé M.3D printing LDPE/lunar regolith simulant composite: Manufacturing with in-situ resources on the Moon.Acta Astronaut. 2025 Dec;237:409-20.Note: From the abstract: “Additive manufacturing is essential for space missions, enabling on-demand production of components where resupply from Earth is limited. Fused deposition modeling (FDM) offers a promising route for repurposing plastic packaging waste into 3D printing feedstock. Low-density polyethylene (LDPE), commonly used in space packaging, can be combined with lunar regolith simulant to increase material availability for in-situ resource utilization (ISRU). However, the method of incorporating regolith into the polymer matrix affects filament quality and printability. Here, we compare single-screw and twin-screw extrusion techniques for producing LDPE/regolith composite filaments containing up to 30 wt% regolith.”
22. Poirier C.Establishing a governance for cyber operations in outer space: Exploring challenges faced by space and cyber commands.Acta Astronaut. 2025 Dec;237:236-42.
23. Shen Y, Jing H, Tang Y, Ai W, Guo S, Zhang L, Mao R, Wu Z.Research on a microgravity-adapted controlled-release fertilizer for space plant cultivation and its application experiments in the Tiangong Space Station.Life Sci Space Res. 2025 Sep 12. Online ahead of print.
24. Wang F, Zhai C.The evolution of space art: Dream, monolith and revelation.Acta Astronaut. 2025 Sep 18. Online ahead of print.Note: From the abstract: “Through academic research and artwork analysis, the paper offers a comprehensive view of Space Art’s interdisciplinary nature and its intersection with art, technology, and society. It also considers the future of Space Art, emphasizing its importance in human engagement with the cosmos and its potential to challenge ideologies and envision new worlds.”

astrobiology, space biology, space medicine, microgravity, ISS,