NASA Spaceline Current Awareness List #1,160 1 August 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Matheson BE, Walle M, Liphardt A-M, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Gabel L, Boyd SK.Recovery of bone microarchitecture and density four years after spaceflight: Two case studies.npj Microgravity. 2025 Jul 28;11(1):47.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: PIs report internal NASA funding. S.R. Zwart, J.D. Sibonga, and S.M. Smith are affiliated with NASA Johnson Space Center.
2. Darby EW, Armstrong SP, Massa GD, Walters KJ.Light intensity and photoperiod interact to alter the phytonutrient profile and light-use efficiency of mizuna grown for the space diet.Sci Rep. 2025 Jul 29;15:27573.PI: K.J. WaltersNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.9
   
   Funding: “This work was funded by the NASA Space Biology Program grant 80NSSC22K0205.”
3. Thompson RS, Hopkins S, Kelley T, Wilson CG, Pecaut MJ, Fleshner M.A prebiotic diet containing galactooligosaccharides and polydextrose attenuates hypergravity-induced disruptions to the microbiome in female mice.Nutrients. 2025 Jul 24;17(15):2417.PI: M.J. PecautNote: This article is part of Special Issue “Advances in Gut Microbial Genomics and Metabolomics in Human Health” (https://www.mdpi.com/journal/nutrients/special_issues/53SG1V2YG1) and may be obtained online without charge.
   
   Journal Impact Factor: 5.0
   
   Funding: “This work was supported by NASA under the grant identification number: 80NSSC19K1038, 16-ROSBFP_PI-0079.”
4. Thomas D, Wu JC.Integrative approaches in cardiac tissue engineering: Bridging cellular complexity to create accurate physiological models.iScience. 2025 Aug 15;28(8):113003.PI: J.C. WuNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 4.1
   
   Funding: “We thank Blake Wu for critical reading of the article and feedback. Manuscript figures were created with BioRender.com. This project was supported by grants from the National Institutes of Health R01 HL141851, R01 HL150693, R01 HL163680, UG3 TR005845, and U01 AI183953 (J.C.W.); K99 HL163443 (D.T.); Department of Energy DE-SC0025363 (J.C.W.); and National Aeronautics and Space Administration 80ARC022CA003 (J.C.W.).”
5. Bjurling J, Chavkin NW, Halvardson J, Thel MC, Mattisson J, Kim JS, Zaghlool A, Ma S-F, Martinez FJ, Anstrom K, Noth I, Walsh K, Forsberg LA.Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis.Commun Med. Jun 28;5:246.PI: K. WalshNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 6.3
   
   Funding: “This study was supported by The European Research Council (101001789), The Swedish Research Council (2022-03452), The Swedish Cancer Society (23 2748 Pj 01 H), Konung Gustav V och Drottning Victorias Stiftelse, The Swedish Heart Lung Foundation (20230779) to L.A.F, National Institutes of Health (HL128964 and UG3HL145266) to I.N., American Heart Association (23CDA154358) to N.C.W., and National Aeronautics and Space Administration (80NSSC21K0549), National Heart, Lung and Blood Institute (HL152174) and National Institute on Aging (AG073249) to K.W.”
6. Shanghavi AA, Jayasuriya J, Cai Y, Mehta RK.Pulse rate variability from wearable wristwatches as a surrogate for heart rate variability? We think not yet.Proc Hum Factors Ergon Soc Annu Meet. 2025 Jul 9;10711813251357929.PI: R.K. MehtaNote: From the abstract: “This study assessed the reliability of pulse rate variability (PRV) from wrist worn photoplethysmography (PPG) as a substitute for heart rate variability (HRV) measured via electrocardiography (ECG), across tasks with varying loads and ambulation.”
   
   Journal Impact Factor: 1.5
   
   Funding: NASA grant #80NSSC24K0485 funding.
7. Tsang Y, Aryeh KS, Wang K, Himmelfarb J, Yeung CK, Kelly EJ.Enhancing therapeutic strategies and drug development for patients with kidney disease.Expert Opin Drug Saf. 2025 Jul 4;1-26. Review.PI: C.K. YeungNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.1
   
   Funding: “Portions of this work were supported by the NASA contract 80ARC023CA001, the National Center for Advancing Translational Sciences (NCATS) [U2CTR004867, UH3TR000504, UG3TR002158], jointly by the NCATS and the Center for the Advancement of Science in Space (CASIS) [UG3TR002178], the National Institute of Environmental Health Sciences (NIEHS) [P30ES00703], Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD102786], an unrestricted gift from Northwest Kidney Centers to the Kidney Research Institute, and the School of Pharmacy at the University of Washington (Ji-Ping Wang Award and Bradley Fellowship).”

Other papers of interest:

1. Umar M, Talha M.Space immunology: unraveling immune system dysregulation in long-duration spaceflight and its implications for Earth-based autoimmune and inflammatory diseases.Immunol Lett. 2025 Jul 25;107063. Online ahead of print.
2. National Academies of Sciences, Engineering, and Medicine.The next decade of discovery in solar and space physics: Exploring and safeguarding humanity’s home in space.Washington, DC: The National Academies Press, 2025. 702 p.Note: Chapters include: Solar and Space Physics; New and Emerging Frontiers in Science; Solar and Space Physics in the Service of Humanity; Toward a Thriving Solar and Space Physics Community; Comprehensive Research Strategy: A HelioSystems Laboratory and Supporting Research and Technology; Summary of Research Strategy and Budget Implications.
3. Berkovich Y, Belyak AM, Erokhin AN, Ivanova AA.[Results of cultivating plants in a prototype of conveyor vitamin space greenhouse Vitacycle-T].Aviakosm Ekolog Med. 2025;59(3):68-76. Russian.
4. Bilichenko AS, Zolotareva AD, Kamkina OV, Zolotarev VI, Rodina AS, Kazansky VE, Mitrokhin VM, Mladenov MI, Kamkin AG.Simulated microgravity attenuates stretch sensitivity of mechanically gated channels in rat ventricular myocytes.Int J Mol Sci. 2025 Jul 11;26(14):6653.Note: Hindlimb unloading study. This article is part of Special Issue “New Insights into Cardiac Ion Channel Regulation 3.0” (https://www.mdpi.com/journal/ijms/special_issues/IOHHK2C57I) and may be obtained online without charge.
5. Cai L, Lv K, Niu H, Ren P, Li H, Xie Y, Liu Y, Li K, Zhang T, Ma X, Fu Y, Xu Z, Shao Y, Lu L, Qiao P, Lv H, Zheng W, Yang C, Wang N, Wang L, Luo D, Qu L, Li Y, Wang Z.Ophthalmic changes are associated with visual cortex functional network reorganization after 90-day head-down tilt bedrest.Quant Imaging Med Surg. 2025 Jul 1;15(7):6360-71.Note: This article may be obtained online without charge.
6. Golaz D, Bürgi L, Egli M, Bigler L, Pessi G.The siderophore phymabactin facilitates the growth of the legume symbiont Paraburkholderia phymatum in aluminium-rich Martian soil.Life (Basel). 2025 Jun 30;15(7):1044.Note: This article is part of Section “Plant Science” (https://www.mdpi.com/journal/life/sections/Plant_Sci) and may be obtained online without charge.
7. Yang X, Liu R, Li K, Zhao X, Wang J, Hou L, Mao L.Quantification of neurotransmitter release dynamics in a hindlimb unloading model via multi-spatiotemporal electrochemistry.Anal Chem. 2025 Jul 27. Online ahead of print.
8. Komissarova DVK, D. N. Pastushkova, L. Larina, I. M., Ilyin VK, Nosovsky AM.[Relationship between levels of blood proteins in a 3-day dry immersion and population of microorganisms in the vaginal biotope and biotope of the cervical channel].Aviakosm Ekolog Med. 2025;59(3):46-56. Russian.
9. Chistov SD.[Experimental evaluation of the sonic boom effect on the human functional condition and operator’s activity].Aviakosm Ekolog Med. 2025;59(3):37-45. Russian.
10. Kuznetsova OS, Lebedeva-Gueorguievskaya KB, Shtemberg AS, Perevezentsev AA, Yasnetsov V.[Study of mexidol as a promising drug for pharmacological correction of the consequences of proton irradiation].Aviakosm Ekolog Med. 2025;59(3):77-83. Russian.
11. Kumar R, Sporn K, Prabhakar P, Paladugu P, Khanna A, Ngo A, Gowda C, Waisberg E, Jagadeesan R, Zaman N, Tavakkoli A.Next-generation biomaterials for load-bearing tissue interfaces: Sensor-integrated scaffolds and mechanoadaptive constructs for skeletal regeneration.J Funct Biomater. 2025 Jun 23;16(7):232. Review.Note: This article is part of Special Issue “Materials and Techniques for Bone Tissue Engineering: From Scaffolds to Complex Matrices” (https://www.mdpi.com/journal/jfb/special_issues/4KETC8UIIA) and may be obtained online without charge.
12. Wang Z, Ma H, Luo J, Yan M, Huang K, Fang J, Ge J, Zeng H.High-precision time-domain stereoscopic imaging with a femtosecond electro-optic comb.Nat Commun. 2025 Jul 24;16(1):6839.Note: This article may be obtained online without charge.

Astrobiology, space biology, space life science, space medicine, Microgravity, ISS,