The encoding step of translation involves attachment of amino acids to cognate tRNAs by aminoacyl-tRNA synthetases, themselves the product of coded peptide synthesis. So, the question arises─before these enzymes evolved, […]
tRNA
Posted inBiochemistry & Organic Chemistry, Genomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
RNA Folding Studies Inside Peptide-rich Droplets Reveal Roles Of Modified Nucleosides At The Origin Of Life
Compartmentalization of RNA in biopolymer-rich membraneless organelles is now understood to be pervasive and critical for the function of extant biology and has been proposed as a prebiotically-plausible way to […]
Posted inGenomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
Superwobbling and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code
The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modifications coevolved with the code.