![These high-resolution pre-catalysis RNA Pol II EC structures also define the reaction-ready configuration of a complete active site. The 1.96 Å cryo-EM map reveals an unambiguous density of Adenosine triphosphate (ATP) substrate with a chair-like triphosphate conformation that is precisely coordinated with two Mg2+ ions. [Full video] Molecular Cell](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/05/Water-molecules-found.png?resize=1200%2C720&ssl=1)
Researchers have uncovered a previously hidden layer of complexity in how genes are activated, showing that water molecules play a direct and essential role in one of the most fundamental […]
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Posted inBiochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Origin & Evolution of Life, Status Report
All Life Copies DNA Unambiguously Into Proteins. Archaea May Be The Exception.
The beauty of the DNA code is that organisms interpret it unambiguously. Each three-letter nucleotide sequence, or codon, in a gene codes for a unique amino acid that’s added to […]
Posted inGenomics, Proteomics, Bioinformatics, Microbiology & Virology, Nomenclature, Systematics, Natural History, Origin & Evolution of Life, Press Release
Ancient Microbes Offer Clues To How Complex Life Evolved
A new study published in Science Advances reveals a surprising twist in the evolutionary history of complex life. Researchers at Queen Mary University of London have discovered that a single-celled […]
Posted inBiochemistry & Organic Chemistry, Biophysics, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Status Report
Genetic Encoding and Expression of RNA Origami Cytoskeletons in Synthetic Cells
The central dogma at the core of molecular biology states that information flows from DNA to RNA and then to protein. Our research seeks to introduce a conceptually novel approach […]