[Acta Biotheoretica] The scientific restlessness surrounding the question of what life is (expressed in the provocations of Feynman and Schrödinger) guides this review article by integrating physics, chemistry, and biology […]
synbio
Posted inNanotechnology & SynBio
Advances in Machine Learning for Directed Evolution: A Five-Year Retrospective
[q-bio.BM] The last five-plus years have seen many protein engineering disciplines transformed by advances in machine learning (ML), but the same cannot be said for directed evolution.
Posted inOrigin & Evolution of Life
The Emergence Of Life In The Light Of Evolution
[q-bio.PE] The origin of life is often framed primarily as a chemical problem, yet life s defining feature is evolution.
Posted inGenomics, Proteomics, Bioinformatics
ExMODE: A Comprehensive Resource For Extremophile Genomic And Functional Exploration
[iMetaOmics] ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat-specific non-redundant genes, 5.25 million representative protein structures, 67,026 metagenome-assembled genomes (MAGs), and 164,132 […]
Posted inBiosignatures & Paleobiology
Molecular Assembly As A Universal Biosignature Measurable By Mass Spectrometry
[PNAS] Detecting life beyond Earth requires biosignatures that do not depend on the chemistry of known organisms.
Posted inNanotechnology & SynBio
Ecological Constraints To Mirror Life
[bioRxiv] Our biosphere exhibits remarkable diversity yet is constrained by universal organizational principles, including molecular homochirality.
Posted inUncategorized
Bioleaching Of Critical Trace Metals By Sphingomonas Desiccabilis: Substrate-driven Selectivity In Earth And Space Analogues
Background – Biotechnological advances are transforming the potential for sustainable resource utilization in space exploration. Biomining, using microorganisms to extract valuable metals, has emerged as a viable strategy for in […]
Posted inOrigin & Evolution of Life
Directing Open-Ended Evolution in Artificial Life via Multi-Scale Path Divergence
Open-ended evolution (OEE) in artificial life is typically driven by uninterpretable, black-box neural-network complexity metrics, leaving life-like systems disconnected from physical theories of complexity.
Posted inBiochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Press Release, Tricorders & Sensors
Tricorder Tech: A Schematic Of Core Steps In The Enzymatic Synthesis Platform
Editor’s note: If you are on a long term mission or on an away team on another world, you might want your tricorder to be able to do some quick […]
Posted inBiophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Nanotechnology & SynBio, Origin & Evolution of Life, Press Release
Scientists Reveal Disease Genes From Reconstruction Of Ancestor To All Complex Life
A University of Texas at Austin-led team has reconstructed the most detailed map to date of the molecular machines that carried out the functions of life in an ancient ancestor […]