[cs.LG] A central challenge in de novo protein design is generating proteins with desired structural and functional properties.
synbio
Posted inOrigin & Evolution of Life
Molecular Complexity As A Signature Of Life
[PNAS Nexus] The presence of an abundance of complex molecules has been proposed as a universal signature of life. Molecular complexity is often measured by the “assembly index,” which calculates […]
Posted inGenomics, Proteomics, Bioinformatics
Pathways Of Early Evolution From The Perspectives Of A Riboreplisome — The Ultimate RNA Machine Of Life
[q-bio.PE] Translation of the genetic code into proteins is universal across life, with ribosomes serving as the ancient molecular machines enabling this information transformation. We propose that early replication and […]
Posted inBiophysics
Balance Between Order and Disorder: Quantum-Epigenetic Pathways for the Emergence and Continuous Evolution of Life
[Acta Biotheoretica] The scientific restlessness surrounding the question of what life is (expressed in the provocations of Feynman and Schrödinger) guides this review article by integrating physics, chemistry, and biology […]
Posted inNanotechnology & SynBio
Advances in Machine Learning for Directed Evolution: A Five-Year Retrospective
[q-bio.BM] The last five-plus years have seen many protein engineering disciplines transformed by advances in machine learning (ML), but the same cannot be said for directed evolution.
Posted inOrigin & Evolution of Life
The Emergence Of Life In The Light Of Evolution
[q-bio.PE] The origin of life is often framed primarily as a chemical problem, yet life s defining feature is evolution.
Posted inGenomics, Proteomics, Bioinformatics
ExMODE: A Comprehensive Resource For Extremophile Genomic And Functional Exploration
[iMetaOmics] ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat-specific non-redundant genes, 5.25 million representative protein structures, 67,026 metagenome-assembled genomes (MAGs), and 164,132 […]
Posted inBiosignatures & Paleobiology
Molecular Assembly As A Universal Biosignature Measurable By Mass Spectrometry
[PNAS] Detecting life beyond Earth requires biosignatures that do not depend on the chemistry of known organisms.
Posted inNanotechnology & SynBio
Ecological Constraints To Mirror Life
[bioRxiv] Our biosphere exhibits remarkable diversity yet is constrained by universal organizational principles, including molecular homochirality.
Posted inUncategorized
Bioleaching Of Critical Trace Metals By Sphingomonas Desiccabilis: Substrate-driven Selectivity In Earth And Space Analogues
Background – Biotechnological advances are transforming the potential for sustainable resource utilization in space exploration. Biomining, using microorganisms to extract valuable metals, has emerged as a viable strategy for in […]