[Tokyo Metropolitan University] Original source (Japanese) https://kyodonewsprwire.jp/release/202609246495 Points We discovered that the linkers (connection points) between ribosomal RNA (rRNA) and transfer RNA (tRNA) in archaea, microorganisms that inhabit high-temperature environments, […]
RNA
![Visual abstract -- [Journal of the American Chemical Society]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/10/Nonequilibrium.jpg?resize=1200%2C716&ssl=1)
Posted inAstrochemistry
Nonequilibrium Formation of Pyridine (C5H5N) in Interstellar Ice Analogs: Implications for Biorelevant Nitrogen Heterocycles in Ryugu and Bennu
[Journal of the American Chemical Society] Biorelevant nitrogen heterocycles, including the five canonical nucleobases found in RNA and DNA, have recently been identified in samples returned from the carbonaceous asteroids […]
Posted inOrigin & Evolution of Life
Computational Modeling Of An RNA-peptide World
[biorxiv.org] Emergence and evolution of functional RNA and protein structures are the central problems for understanding the origin of life.
Posted inOrigin & Evolution of Life
Structure Of An RNA polymerase Ribozyme Replication Complex
[biorxiv.org] Life began with the emergence of a molecule that could replicate its own genetic material, a task plausibly mediated by an RNA-dependent RNA polymerase ribozyme.
![Graphical abstract -- [biorxiv.org]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/09/tinyRNA-seq.png?resize=1200%2C717&ssl=1)
Posted inGenomics, Proteomics, Bioinformatics
tinyRNA-seq: An Optimized Approach To Sequencing Tiny RNAs And Primitive RNA Genomes
[biorxiv.org] Very short RNAs play critical roles in modern biology, and are thought to have been crucial for genome replication during the origin of life.
![A symbiotic scenario for co-evolution of the ribosome and the replicase. Two variations of the scenario are depicted, whereby the peptidyltransferase center (PTC) and the replicase (REP) ribozymes are encoded by distinct (A) or the same (B) RNA molecule. The figure depicts three major stages of cellular evolution from the primordial RNA world (left) to the intermediate RNA-protein world (center) and the last universal cellular ancestor (LUCA, right). The major events occurring during each stage are briefly described in the corresponding information boxes at the bottom of the figure. -- [q-bio.PE]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/08/The-selfish.png?resize=1200%2C712&ssl=1)
Posted inGenomics, Proteomics, Bioinformatics
The Selfish Ribosome
[q-bio.PE]. The ribosome is responsible for protein synthesis in all cells, and is the largest energy consumer in the cell.
Posted inOrigin & Evolution of Life
RNA Droplets May Have Helped Start life on Earth
[University at Buffalo] It’s one of the origins of life’s chicken-or-the-egg problems: How could RNA have helped give rise to the first cells before there were cells to contain them?
Posted inOrigin & Evolution of Life
Liquid–liquid Phase Separation As A Driver Of Abiogenesis And Evolution
[Academia Molecular Biology and Genomics] The origin of life may have emerged through physical mechanisms that enable molecular organization and self-assembly.
Posted inGenomics, Proteomics, Bioinformatics
Pinpointing Where Cells First Begin Copying DNA
[Medical Research Council (MRC) Laboratory of Medical Sciences] Every time a cell divides, it must faithfully copy its entire genetic instruction manual. Errors during this process can damage the genome, […]
![a) Biological evolution as stochastic optimization: Initially, wild-type cells x grow up a population. A mutant y grows up a population. The populations x and y compete. The winner (greater population) then fetches more resources. Fitness landscapes at the bottom show how the mutant is an experiment, where the winner decides the next step direction. b) Evolution annotated in terms of the Central Dogma: (Left, green) Wildtype starting point, NA encodes PR, which gives fitness F. (Top, red), Mutation in the blueprint NA, becoming NA’. (Red, green) both NA sequences grow up into populations. (Next) The populations compete for fitness. The winner, Fx now carries with it the winning sequence NAx and protein P Rx. -- [biorxiv.org]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/RNA-And-Proteins.png?resize=1200%2C720&ssl=1)
Posted inOrigin & Evolution of Life
RNA And Proteins Joined Up At The Origins Of Life: Persistence Is The Point
[biorxiv.org] What drove nucleic acids (NA) to associate with proteins (PR) at the Origins of Life? We reason from polymer physics and the Central Dogma (CD) that the fitness value […]