The ubiquitous, evolutionarily oldest RNAs and proteins exclusively use rather rare zinc as transition metal cofactor and potassium as alkali metal cofactor, which implies their abundance in the habitats of […]
RNA world
An RNA Condensate Model For The Origin Of Life
The RNA World hypothesis predicts that self-replicating RNAs evolved before DNA genomes and coded proteins. Despite widespread support for the RNA World, self-replicating RNAs have yet to be identified in […]
Protocell Effects on RNA Folding, Function, and Evolution
Creating a living system from nonliving matter is a great challenge in chemistry and biophysics. The early history of life can provide inspiration from the idea of the prebiotic “RNA […]
The RNA World With Inhibitors
During the evolution of the RNA World, compartments, which were fragments of space surrounded by a primitive lipid membrane, had to have emerged.
Astrochemistry: The Mystery of Life’s Handedness Deepens
The mystery of why life uses molecules with specific orientations has deepened with a NASA-funded discovery that RNA — a key molecule thought to have potentially held the instructions for […]
Protocell Effects on RNA Folding, Function, and Evolution
Creating a living system from nonliving matter is a great challenge in chemistry and biophysics. The early history of life can provide inspiration from the idea of the prebiotic “RNA […]
A New Biochemistry For RNA At Low Temperatures
Ribonucleic acid (RNA) is a biological molecule with crucial functions in the genetics of organisms and plays a key role in the origin and evolution of life. With a composition […]
RNA World: Overcoming Nucleotide Bias In The Nonenzymatic Copying Of RNA Templates
The RNA World hypothesis posits that RNA was the molecule of both heredity and function during the emergence of life.
RNA-Catalyzed Evolution
NASA-supported researchers have used a laboratory technique called directed evolution to create an RNA enzyme that is capable of carrying out RNA polymerase activity. In living cells, protein polymerases catalyze […]
Early Replicators
Mathematical models of how ribonucleic acid (RNA)-like molecules make copies of themselves reveal new insights as the origins of life on Earth.
