[University of Notre Dame] In most modern cells, DNA stores the genetic blueprint, and relies on proteins to replicate, repair and build from those blueprints. At the same time, proteins […]
origin of life
![Outline of construction of plasmids carrying LUCA and E. coli tRNA genes and codon test genes. A LUCA and E. coli tRNA genes. Pairs of tRNA genes from E. coli and LUCA with identical anticodon sequences were synthesized. Primers (Supplementary Table S2) were used to amplify the transcription templates for in vitro synthesis. B Codon test genes. The constructs were based on the pET23a vector. Test genes were inserted between the NdeI and BamHI sites, with the start codons included in the NdeI site. -- [Journal of Molecular Evolution]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/Resurrecting-tRNAs.png?resize=1200%2C716&ssl=1)
Posted inOrigin & Evolution of Life
Resurrecting tRNAs of the Last Universal Common Ancestor (Commonote) Toward Rebuilding the Ancient Translation System
[Journal of Molecular Evolution] Ancestral sequence reconstruction (ASR) was used to study the evolution of the translational system by inferring tRNA sequences of the Last Archaeal Common Ancestor (LACA), the […]
Posted inAstrogeology
Diverging Mineral Chemistry of Iron and Nickel Throughout Earth’s Changing Redox Conditions Reveals Foundation for Their Evolution as Protein Cofactors
[LIFE] Iron (Fe) and nickel (Ni) were both foundational to early metabolism, yet their biological trajectories diverged as Earth’s surface redox state changed. Here, we integrate mineral chemistry network analysis, […]
![Potential environments for the origin of life and the corresponding roles of minerals. (a) In the deep-sea hydrothermal vent hypothesis, metal sulfides play a critical role in the formation of chemical precursors and building blocks. (b) In terrestrial hot spring, minerals may concentrate and stabilize molecular building blocks, catalyze polymerization under wet–dry cycling conditions, and provide protection against environmental stresses. (c) Extraterrestrial input of organic matter through meteorites, comets and IDPs. Minerals are the carrier and preserver of organic compounds and may possibly take part in the prebiotic synthesis of organic compounds in extraterrestrial environments. (Background images are modified based on AI-generated illustrations.) -- [Fundamental Research]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/07/The-role-of-minerals.png?resize=1200%2C717&ssl=1)
Posted inOrigin & Evolution of Life
The Role Of Minerals In Prebiotic Evolution: Implications For Identifying Worlds With The Potential For Life’s Origin
[Fundamental Research] Understanding the origin of life requires explaining how abiotic molecules transitioned into the first living systems within plausible geological settings. Increasing evidence suggests minerals as active participants in […]
Posted inOrigin & Evolution of Life
The Biological Cosmological Constant ΛB: Exploratory Propensity, Dynamical Habitability And The Geometric Origin Of Life
[BioSystems via PubMed] The emergence of life represents a fundamental geometric phase transition in the state space of complex systems, rather than a mere sequence of chemical syntheses. Building upon […]
Posted inUncategorized
Hydrothermal Origin Of Metabolic Phosphorylation
Phosphate is central to modern bioenergetics and to all theories for the origin of life. How phosphate entered metabolism is unknown, though microbial physiology and geochemical environments can provide important […]
Posted inOrigin & Evolution of Life
Directing Open-Ended Evolution in Artificial Life via Multi-Scale Path Divergence
Open-ended evolution (OEE) in artificial life is typically driven by uninterpretable, black-box neural-network complexity metrics, leaving life-like systems disconnected from physical theories of complexity.
Posted inOrigin & Evolution of Life
Abiotic Sources Of Fixed Nitrogen Sustained Early Ecosystems For Several Hundred Million Years After The Origin Of Life
Nitrogen (N) plays a crucial role in controlling biological productivity. However, it remains unknown how Earth’s earliest ecosystems accessed bioavailable forms of nitrogen.
Posted inAstrochemistry, Atmospheres, Climate, Weather, Biochemistry & Organic Chemistry, Biogeochemical Cycles & Geobiology, Biophysics, Biosignatures & Paleobiology, Origin & Evolution of Life, Status Report
Terrestrial Abiotic Synthesis of Simple Precursor Molecules Starting from Two Approaches: The Universality of Carbon Reduction
To address the chemistry responsible for life’s emergence, we examine the simple chemicals accessible on early Earth and the processes that could have transformed them. We focus on carbon reduction […]
Posted inGenomics, Proteomics, Bioinformatics, Microbiology & Virology, Origin & Evolution of Life, Plant Biology, Press Release
Nucleomorph Phylogenomics Suggests A Deep And Ancient Origin Of Cryptophyte Plastids Within Rhodophyta
The evolutionary origin of red algae‐derived complex plastids remains obscure. Cryptophyta, one of four eukaryotic lineages harboring these plastids, still contains nucleomorphs, which are highly reduced remnants of red algal […]