The emergence of RNA on the early Earth is likely to have been influenced by a series of chemical and physical processes that acted to filter out various alternative nucleic […]
nucleotides
Posted inAstropharmacy / Biotechnology, Biochemistry & Organic Chemistry, Genomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
Expanding The Natural Genetic Code – Implications For SynBio And Origin Of Life?
Editor’s note: The genetic code of all life (with a few minor exceptions) on our home world is based on a genomic code consisting of 4 standard nucleotides. It is […]
Posted inGenomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Origin & Evolution of Life, Press Release
Enzymes Can’t Tell Artificial DNA From The Real Thing
The genetic alphabet contains just four letters, referring to the four nucleotides, the biochemical building blocks that comprise all DNA.
![Type II tRNA evolved via RNA ligation and a 9 nt internal deletion within ligated 3′- and 5′-acceptor stems [42]. Also, 3 31 nt minihelices (one D loop minihelix (magenta 17 nt core) and two anticodon stem-loop-stem minihelices (blue 17 nt core)) were fused by ligation for minihelix replication. The 93 nt tRNA precursor was processed by an internal 9 nt deletion (see below) within fused 3′-acceptor (yellow) and 5′-acceptor (green) stems. In the type II tRNA structure, the red arrow indicates the fusion of the magenta segment (17 nt D loop minihelix core; UAGCC repeat) and the green segment (5′-acceptor stem fragment; initially GGCGG). Abbreviations: SLS) stem-loop-stem; Ac) anticodon. Molecular graphics were created using ChimeraX [43]. -- Life](https://i0.wp.com/astrobiology.com/wp-content/uploads/2023/11/The331NucleotideMinihelix.png?resize=1200%2C720&ssl=1)
Posted inGenomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
The 3 31 Nucleotide Minihelix tRNA Evolution Theorem and the Origin of Life
There are no theorems (proven theories) in the biological sciences. We propose that the 3 31 nt minihelix tRNA evolution theorem be universally accepted as one.
Posted inGenomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
The RNA-DNA World And The Emergence Of DNA-encoded Heritable Traits
The RNA world hypothesis confers a central role to RNA molecules in information encoding and catalysis.
Posted inBiochemistry & Organic Chemistry, Genomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Press Release
A Prebiotic Genetic Alphabet As An Early Darwinian Ancestor For Pre-RNA Evolution
RNA-based genetic code is thought to be central to life’s emergence due to its dual ability for information transfer and catalysis. Nonetheless, the genetic code of early life was potentially […]