Recently, plenty research has been done on discovering the role of energy dissipation in biological networks, most of which focus on the relationship of dissipation and functionality.
biosphysics
![Overview. (a) Composition of a bacterial cell by weight, with a breakdown of the chemical constituents [21]. About 40% of these compounds are not properly covered in existing datasets. (b) Multi-step workflow used to construct QCell, beginning with the selection of building blocks, followed by conformational sampling and fragment selection, pre-optimization with DFTB+MBD, and finally hybrid PBE0+MBD(-NL) calculations. (c) Coverage of molecular species at the PBE0+MBD(-NL) level of theory, including entries from existing databases and newly generated QCell data for nucleic acid fragments, lipids, sugars, solvated ions, and dimers. -- AI for Science](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/04/Mapping-The-Molecules-Of-Life.png?resize=1200%2C719&ssl=1)
Posted inAI - Data - Apps - Cybernetics, Astropharmacy / Biotechnology, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Status Report, Tricorders & Sensors
Mapping The Molecules Of Life: Expanding The Quantum-mechanical Foundation For Biomolecular AI
Machine learning force fields (MLFFs) are rapidly transforming molecular simulations by combining the accuracy of quantum mechanics with the speed of classical approaches. However, training reliable MLFFs for biological systems […]
Posted inBiochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Origin & Evolution of Life, Status Report
Metrology of Complexity and Implications for the Study of the Emergence of Life
One of the longest standing open problems in science is how life arises from non-living matter.
Posted inAstrochemistry, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Nanotechnology & SynBio, Origin & Evolution of Life, Status Report
Theoretical Perspective On Synthetic Life: Learning From The Origin Of Life
Creating a man‐made life in the laboratory is one of life science’s most intriguing yet challenging problems.
Posted inAtmospheres, Climate, Weather, Biochemistry & Organic Chemistry, Biogeochemical Cycles & Geobiology, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Habitable Zones, Magnetic Fields, Electromagnetism, bioelectricity,, Origin & Evolution of Life, Press Release, Water/Hycean Worlds & Oceanography
Microlightning In Water Droplets May Have Sparked Life On Earth
Life may not have begun with a dramatic lightning strike into the ocean but from many smaller “microlightning” exchanges among water droplets from crashing waterfalls or breaking waves.
![The logic of self-replicating living “machines”. Cells reproduce through a complex process that uses DNA as a set of instructions but requires also DNA to be replicated. In von Neumann’s theory (a), a formal machine capable of copying itself would require a set of instructions to guide the construction of a new machine under some controlled states such that instructions also get replicated. In biology, one crucial component of the cellular translation machinery is the ribosome (b), made of two subunits (RibLU and RibSU) that “read” RNA strings to synthesise proteins, playing the role of the Constructor. In a molecular, embodied implementation of cell reproduction, self-organised interactions between a compartment, metabolism and information must interact. An example of a simple implementation is shown in (c) for a synthetic cell involving a compartment coupled to double-stranded polymers and a minimal metabolism (adapted from [127]). Here, a precursor pL is transformed into lipids (L) that allow membrane growth until some instability triggers division. -- preprints.org](https://i0.wp.com/astrobiology.com/wp-content/uploads/2024/06/Fundamental-Constraints-To-The-Logic-Of-Living-Systems.png?resize=1200%2C720&ssl=1)
Posted inBiophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Status Report
Fundamental Constraints To The Logic Of Living Systems
It has been argued that the historical nature of evolution makes it a highly path-dependent process. Under this view, the outcome of evolutionary dynamics could have resulted in organisms with […]