NASA Spaceline Current Awareness List #1,198 1 May 2026 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Fisher KE, Settles AM.Efficient long-term cryopreservation of Arthrospira platensis NIES-39 and adaptation for the Space Algae-2 spaceflight experiment.npj Microgravity. 2026 Apr 22.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “We thank Jared Brodderick for insightful discussions of our pre-publication data for this study. This work was supported by NASA Space Biology Grant 18-FG_2-0059.”
2. Puzantian B, Beaton-Green LA, Grzegorcyk P, Lai V, Daoust VC, Tomi L, Wu H, Wilkins RC.Evaluation of chromosome aberrations in astronaut lymphocytes after long-duration missions to the International Space Station.Life Sci Space Res. 2026 Apr 26. Online ahead of print.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 2.8
   
   Funding: H. Wu is affiliated with NASA Johnson Space Center.
3. Brawley HN, Arenaz C, Mashimo T, Rosa RH Jr, Pham DL, Hein TW, Zwart SR, Smith SM, Stover PJ.In search of a mouse model of spaceflight associated neuro-ocular syndrome using one-carbon genetics.Sci Rep. 2026 Apr 27. Early access article.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.9
   
   Funding: S.R. Zwart and S.M. Smith are affiliated with NASA Johnson Space Center.

Other papers of interest:

1. Goswami N, Batzel JJ, Ma YJX, Fredriksen PM, Green DA, Ivanov P.Network physiology in space: Vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on Earth.Front Net Physiol. 2026 Apr 23;6:1817815.Note: This article is part of Research Topic “Network Physiology in Space: Exploring Physiological Networks during Space Flight for the Benefit of Life on Earth” (https://www.frontiersin.org/research-topics/75817/network-physiology-in-space-exploring-physiological-networks-during-space-flight-for-the-benefit-of-life-on-earth) and may be obtained online without charge.
2. Katsev BD, Lee R, Kim JH, Leigh A, Ong J, Waisberg E, Lacy AJ, Mader TH, Gibson CR, Berdahl J, Lee AG.Space radiation effects on the glutathione redox cycle and cataract formation.Aerosp Med Hum Perform. 2026 May 1;97(5):354-61. Review.
3. Li C, Shen S, Zhang H, Liu T, Miao R, Liu H, Li Y.Integrated physiological characteristics and proteomes of Bacillus licheniformis response to 6-month spaceflight.J Proteomics. 2026 Jun 30;105662.Note: From the abstract: “Bacillus licheniformis (BL) is used for clinical treatment of acute and chronic enteritis and diarrhea. The present study explored the physiological characteristics and proteomes of BL response to 6-month spaceflight aboard the China Space Station.”
4. Pavlidis T, Mortreux M, Charidemou E.Nutrition-based interventions for mitigating space radiation-induced DNA damage: A systematic review and meta-analysis.Life Sci Space Res. 2026 Apr 3. Online ahead of print.Note: This article may be obtained online without charge.
5. Song W, Wen Y, Yue X, Liu C, Han Y, Sun J.BioKMS-HAG: A hierarchically guided biomedical and space science knowledge fine-grained mining system.Life Sci Space Res. 2026 May;50:63-80.Note: From the abstract: “The rapid growth of biomedical data and advancements in artificial intelligence have created unprecedented opportunities for scientific discovery. However, effectively leveraging these technologies requires integrating cutting-edge methods into accessible tools. In this study, we develop the Biomedical Knowledge Mining System (BioKMS) that integrates knowledge graph construction and advanced link prediction with the Hierarchy Guided Approach for Fine-Grained Biomedical Hypothesis Generation (HAG).”
6. Bonnard T, Morello A, Doat E, Cazalets J-R, Guehl D, Guillaud E.Resilience of otolithic reflex to gravitational changes.npj Microgravity. 2026 Apr 27. Early access article.Note: This article may be obtained online without charge.
7. Kilic KD.Future challenges for astrocytology, astroembryology and astrohistology.npj Microgravity. 2026 Apr 24. Early access article.Note: This article may be obtained online without charge.
8. Roshdy MR, Botros M, Mokhles A, Matwiejuk W, Keriakos AR.Microgravity-induced ocular changes assessed by optical coherence tomography.Aerosp Med Hum Perform. 2026 01 May 2026;97(5):362-71. Review.Note: Head-down tilt study.
9. Szaflarska B, Walczak K, Czepiel M, Kołodziejczyk A, Pamuła E.The influence of simulated microgravity on MG-63 osteoblast-like cells cultured on polymeric scaffold.Biomater Biosyst. 2026 Jun;22:100137.Note: A random positioning machine (RPM)/3D clinostat was used to simulate microgravity in this study. This article may be obtained online without charge.
10. Tyrina EA, Andrianova IV, Andreeva ER, Romanov YA, Buravkova LB.Human multipotent mesenchymal stromal cells exhibit resistance to long-term simulated microgravity.Bull Exp Biol Med. 2026 Apr 24.Note: The method of simulated microgravity is not evident in the available abstract.
11. Xin Y, Yang C, Wang G, Ma H, Jing L.Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction.Front Physiol. 2026 Apr 22;17:1781613.Note: This article is part of Research Topic “Physiological and Pathological Responses to Hypoxia and High Altitude, Volume IV” (https://www.frontiersin.org/research-topics/74860/physiological-and-pathological-responses-to-hypoxia-and-high-altitude-volume-iv/articles). The Research Topic also includes articles from previous Current Awareness Lists #1,183 (https://doi.org/10.3389/fphys.2025.1724998) and #1,186 (https://doi.org/10.3389/fphys.2026.1746894). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
12. Zhang X, Wei L, Li X, Luo Y, Yuan J, Tan Q, Mu H.The association between bistable perception stability and performance in simulated flight operations.Aerosp Med Hum Perform. 2026 May 1;97(5):337-43.
13. Kubota K.The missing discipline in space health operations: Nursing as mission assurance.Life Sci Space Res (Amst). 2026 May;50:60-2.Note: This is an Opinion/Position paper and may be obtained online without charge.
14. Mani C, Bates K, Mongrain R, Leask RL.Development of a platform for in vitro hemodynamic measurements in varying gravity profiles.Aerosp Med Hum Perform. 2026 May 1;97(5):316-26.Note: From the abstract: “This work presents a novel in vitro carotid bifurcation model enabling high-resolution analysis of flow behavior across static and transient gravity profiles and orientations, focusing on mechanisms driving cerebral hypoperfusion.”
15. Ayi-Bonte D, Dworacek S, Madden J, Evans J, Lofgren IE, Melanson KJ, Ward-Ritacco CL, Mortreux M.Estrogen receptor alpha (ERα) is involved in resveratrol-mediated muscle preservation during mechanical unloading in male rats.Muscles. 2026 Mar 25;5(2):23.Note: This article may be obtained online without charge.
16. Hunter DI, Sunnerberg JP, Tavakkoli AD, Sloop A, Petusseau B, Gui J, Cao X, Zhang R, Swartz HM, Jarvis LA, Jack Hoopes P, Gladstone D, Pogue BW.Systematic tissue oxygen variation shows the modulation of murine skin radiation toxicity at ultra-high dose rates.Phys Med Biol. 2026 Apr 24. Online ahead of print.Note: This article may be obtained online without charge.

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