NASA Spaceline Current Awareness List #1,153 13 June 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Reddy RV, Ong J, Lee R, Sampige R, Waisberg E, Gibson CR, Berdahl J, Mader TH.Space radiation and risk for ocular surface malignancies: Exposure risk, current mitigation strategies, and management considerations for a mission to Mars.Life Sci Space Res. 2025 Jun 7. Review. Online ahead of print.Journal Impact Factor: 2.9
   
   Funding: C.R. Gibson is affiliated with NASA Johnson Space Center.
2. Lozzi B, Adepoju L, Espinoza JL, Padgen M, Parra M, Ricco A, Castro-Wallace S, Barrick JE, O’Rourke A.Simulated microgravity triggers a membrane adaptation to stress in E. coli REL606.BMC Microbiol. 2025 Jun 9;25(1):362.PI: A. O’RourkeNote: High aspect ratio vessels and a rotating wall vessel were used in this study. This article may be obtained online without charge.
   
   Journal Impact Factor: 4.0
   
   Funding: “Funding acquisition, by A.O through Early Career funding from NASA’s Mars Campaign Office (MCO) Polaris Project. Additional support from the National Science Foundation (DEB-1951307) to J.E.B.”
3. Pineda EN, Nounamo B, Du R, Larrey EK, Gilreath C, Cook H, Boerma M, Koturbash I, Pathak R.Sex-specific immune alterations in mice following long-term simulated microgravity and chronic irradiation.npj Microgravity. 2025 Jun 12;11:24.Note: Hindlimb unloading study. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was funded by a NASA-EPSCoR under grant number 80NSSC21M0323 (RP) and partially supported by a collaborative research grant from the National Institute of Allergy and Infectious Diseases (NIAID) under grant number 5U01AI170039 (RP); the National Institute of General Medical Sciences (NIGMS) under grant number P20 GM109005 (RP).”
4. Carter CW Jr, Tang GQ, Patra SK, Dieckhaus H, Kuhlman B, Douglas J, Wills PR, Bouckaert R, Popovic M, Ditzler MA.Structural enzymology, phylogenetics, differentiation, and symbolic reflexivity at the dawn of biology.Genome Biol Evol. 2025 Jun 6;17(6):evaf095. Online ahead of print.PI: M.A. DitzlerNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.1
   
   Funding: PI reports partial funding by “Evolutionary Processes That Drove the Emergence and Early Distribution of Life (EPDEL).”
5. Prokopidis K, Varanoske AN, Veronese N, Kirk B, Triantafyllidis KK, Giannaki CD, Stavrinou PS, Church DD, Duque G.Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: A systematic review.Aging Clin Exp Res. 2025 Jun 9;37(1):183.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.4
   
   Funding: A.N. Varanoske is affiliated with NASA Johnson Space Center.
6. Turner RT, Wong CP, Philbrick KA, Keune JA, Labut EM, Menn SA, Branscum AJ, Iwaniec UT.Adoptive transfer of Lepr⁺ bone marrow cells attenuates the osteopetrotic phenotype of db/db mice.Int J Mol Sci. 2025 May 21;26(11):5120.PI: R.T. TurnerNote: This article is part is Special Issue “Advances in Leptin Biology” (https://www.mdpi.com/journal/ijms/special_issues/82MKPC20L3) and may be obtained online without charge.
   
   Journal Impact Factor: 4.9
   
   Funding: “This work was supported by grants from the National Institutes of Health (AR060913) and the National Aeronautics and Space Administration (NNX12AL24G and 80NSSC20K0998).”

Other papers of interest:

1. Coblentz M, Evans JD, Kothe CI, Mak T, Valerón NR, Chwalek P, Wejendorp K, Garg S, Pless L, Mak S, Sörensen PM, Jahn LJ, Ekblaw A.Food fermentation in space: Opportunities and challenges.iScience. 2025 Apr 18;28(4):112189.Note: This article may be obtained online without charge.
2. Sun P, Gao X, Wei D, Ge J, Deng X, Chen H, Yang H, Gao J, Yang J.The digestive system under microgravity environment: Changes, mechanisms and the prospects of the future.Gastrointest Endosc. 2025 Apr;3(2):108-15.Note: From the abstract: “In recent years, the space industry has continued to improve and develop, and human beings have been staying in space for longer periods while facing the challenges of microgravity to human life. The normal functioning of the digestive system is an important prerequisite for astronauts in carrying out their missions. Microgravity can have a wide range of effects on the digestive system. In this article, we summarized the literature of recent years and provided an overview of the research progress around the effects of weightlessness on the digestive system and microgravity medicine at the cellular, molecular, and metabolic levels.”
3. Chen X, Zuo J, Huang W, Liu W, Zhang Y, Lin W, Zhao Y, Huang P, Fu J.[Research on the design and application of virtual reality simulation for space station extravehicular activities.]Space Med Med Eng. 2025;(1):58-64. Chinese.
4. Fu Z, Xie Z, Shao Y, Wang N.[Effects of eye movement on the subarachnoid space of the optic nerve in patients with idiopathic intracranial hypertension.]Space Med Med Eng. 2025;(1):15-20. Chinese.
5. Liu W, Xu Z, Zhang Y, Guo J, Zhang Z, Wang Y, Xuan Y, Jiang M.[Design and verification of accurate measurement of human mass in microgravity environment.]Space Med Med Eng. 2025 (1):50-7. Chinese.
6. Liu Z, Zhang L, Zhang Z, Shang S, Zhang Z.[Effects of space microgravity on osteoporosis.]Space Med Med Eng. 2025 (1):75-80. Chinese.
7. Wang Z, Zhang X, Tian Y, Song X, Ge X, Wang L, Zhao R, Sun Z, Wang C.[The influence of long-term spaceflight on the speed perception.]Space Med Med Eng. 2025;(1):7-14. Chinese.
8. Bothe TL, Heinz V, Pilz N, Fesseler L, Patzak A, Bruckstein R, Nordine M, Gunga HC, Opatz O.Peripheral skin cooling during gravitational challenges in parabolic flight – experimental protocol, implementation, and case study of the CoolFly experiment.Front Physiol. 2025 May 26;16:1477311.Note: This article is part of Research Topic “Aerospace Health and Safety: Today and the Future, Volume II” (https://www.frontiersin.org/research-topics/50619/aerospace-health-and-safety-today-and-the-future-volume-ii/overview). The Research Topic also includes articles from previous Current Awareness Lists #1,085 https://doi.org/10.3389/fphys.2023.1298672 and #1,128 https://doi.org/10.3389/fphys.2024.1325513. This article may be obtained online without charge.
9. Degens H, Messa GAM, Tallis J, Bosutti A, Venckunas T, Adeniran I, Wüst RCI, Hendrickse PW.Diffusion and physical constraints limit oxidative capacity, capillary supply, and size of muscle fibers in mice and humans.Exp Physiol. 2025 Jun 7. Online ahead of print.Note: This article may be obtained online without charge.
10. Litvak M, Mitrofanov I, Sanin A, Golovin D, Nikiforov S, Lisov D, Yakovlev V.Neutron radiation dosimetry on Mars.Acta Astronaut. 2025 Sep;234:186-93.Note: From the Introduction: “Mars is the planet of the Solar system that may become inhabited by humans in the future. Today Mars is considered as the next destination for humans after an expedition to the Moon. Accordingly, the possible risks of a mission to Mars are widely discussed, and one of them is the hazardous radiation environment on the Martian surface. The planet has a thin atmosphere and does not have a magnetosphere that could protect its surface from the irradiation by charged particles of Galactic Cosmic Rays (GCR). They produce secondary emission of neutrons in the Martian subsurface, with energies varying within a broad range from thermal neutrons up to tens of GeV (e.g. see Refs.). Its contribution to the total radiation dose is not constant and depends on many factors/conditions including subsurface elemental composition, thickness of the atmosphere, seasonal changes. Also, it is known that a higher content of hydrogen in the subsurface leads to a lower flux of high energy and epithermal neutrons, but it produces more thermal particles (e.g. see Refs.). So, the content of water has a significant influence on the neutron component of radiation background.”
11. Porczak AE, Feng NY.Hibernation as a model for skeletal muscle preservation.Ann N Y Acad Sci. 2025 Jun 9. Review. Online ahead of print.Note: From the abstract: “In this review, we explore skeletal muscle homeostasis at multiple levels of biological organization, from function, neural innervation, gross anatomy, cellular differentiation, ultrastructure, to biochemical pathways regulating regeneration, growth, and degeneration.”
12. Ren LJ, Yu Y, Hua C, Xie YZ, Yao WJ, Liang JY, Li CL, Zhang TY.Interference pattern caused by bilateral bone conduction stimulation impairs sound localization.Adv Sci (Weinh). 2025 Jun 10;e00302. Online ahead of print.Note: This article may be obtained online without charge.
13. Seehanam S, Aung HH, Tobsri R, Kaewkumpha Y, Sithipreedanant C, Kladsamniang N, Sripumkhai W, Pattamang P, Ngamkajornwiwat P, Chansataporn W, Chancharoen W.Universal and economical experimental platform for colloidal mixing lab-on-chip in parabolic flight.Sci Rep. 2025 Jun 6;15(1):19971.Note: From the introduction: “An emulsion is a heterogeneous colloidal system consisting of two immiscible liquid phases, one of which is dispersed as microscopic droplets throughout the continuous phase of the other liquid. The process of Emulsification either forms these systems or reduces droplet size in existing ones, with stability maintained by interfacial active agents such as surfactants or solid particles. Emulsions are well known because of their wide use in the food, pharmaceutical, and cosmetic industries, but their capacity for encapsulation and their stability have now led to their emergence as a promising technology in other areas, such as nutrition and medication delivery media for use in deep space. Deep space missions require food and medicine systems that maintain the integrity of the contents under microgravity and extend storage conditions. Emulsions excel in this context because of their capacity to encapsulate both hydrophilic and hydrophobic compounds, thereby enabling the development of compact, energy-dense formulations. For example, nano-emulsions show promise for delivering fortified beverages that can supplement astronaut nutrition while providing an extended shelf life. Therefore, the use of emulsions could address the present challenges that limit long-term drug stability in space environments.”
14. Stout JA, Gerow DE, Clegg PC, Metzler-Wilson K, Wilson TE.Alternate quantification approaches for cold-induced vasodilation in human glabrous skin.Front Physiol. 2025 Jun 10;16:1575764.Note: From the abstract: “Cold-induced vasodilation (CIVD) is a counterintuitive focal increase in glabrous skin blood flow during cold exposure with unclear local and neural mechanisms.” This article may be obtained online without charge.
15. Tanaka Y, Ariga A, Bruckmayr C, Dinulović P, Kose U, Sachdeva R.A preliminary design of cloud chamber for enhancing interconnections between cosmic rays and humans.Acta Astronaut. 2025 Jun 11. Online ahead of print.
16. Warneke K, Afonso J, Thomas E, Rittweger J, Konrad A, Moser O, Lohmann LH, Zech A, Schoenfeld BJ, Behm DG.Implications and applications of stretch-mediated hypertrophy in therapy, rehabilitation, and athletic training-An outlook to future potential applications.Sports Med. 2025 Jun 6. Online ahead of print.

Astrobiology, space biology, space life science, space medicine, Microgravity, ISS,