NASA Spaceline Current Awareness List #1,182 9 January 2026 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. D’Addabbo P, De Grassi A, De Luca DI, Scaglione V, Francavilla AL, Todisco S, Sgobba MN, Guerra L, Volpicella M, Beheshti A, Pierri CL.SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: The ADP/ATP carrier (AAC3) as a structural case study.J Transl Med. 2025 Dec 30.PI: A. BeheshtiNote: GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
   
   Journal Impact Factor: 7.5
   
   Funding: PI reports NASA funding from E.9 ROSES grant.
2. Kim J, Sakharkar A, Hirschberg JW, Schanzer N, Feinstein Z, LeRoy EW, Burke M, Kurt KC, Ryon K, Parimoo S, Berliner A, Nelson TM, Mason CE.Chapter 7 – Astronaut multi-omics.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 97-119.PI: C.E. MasonFunding: PI reports NASA funding.
3. Schuerger AC, Soltez KSN, Paul AL, Ferl R.Simulated microgravity enhances germ tube elongation by Golovinomyces cichoracearum on Cucurbita pepo and Arabidopsis thaliana leaves.Phytopathology. 2025 Dec 15. Online ahead of print.PI: A.C. SchuergerNote: From the abstract: “Leaves were positioned into one of five gravity treatments including: (1) adaxial leaf surfaces pointed upward (1g-up control), (2) adaxial surface oriented 90° to Earth’s 1g down vector (1g-90° control), (3) adaxial surfaces pointed down (1g-down control), (4) rotated on a 2D clinostat, or (5) randomly rotated on a 3D random positioning machine (RPM).”
   
   Journal Impact Factor: 3.1
   
   Funding: NASA grant #80NSSC22K0209 funding.
4. Stephanian B, Ong J, Lee R, Gibson R, Berdahl J, Waisberg E, Mader TH, Lee AG.Ocular matrix metalloproteinases in spaceflight.Aerosp Med Hum Perform. 2026 Jan 1;97(1):47-54. Review.Journal Impact Factor: 0.9
   
   Funding: R. Gibson is affiliated with NASA Johnson Space Center.
5. Ryder VE, Yap DA.Spacecraft maximum allowable concentrations for 1-propanol.Aerosp Med Hum Perform. 2026 Jan 1;97(1):60-3.Journal Impact Factor: 0.9
   
   Funding: V.E. Ryder and D.A. Yap are affiliated with NASA Johnson Space Center.
6. Wong CP, Keune JA, Philbrick KA, Branscum AJ, Iwaniec UT, Turner RT.Introduction of mature mast cells into bone marrow alters bone metabolism in growing mice.Int J Mol Sci. 2025 Dec 11;26(24):11952.PI: R.T. TurnerNote: This article is part of Special Issue “Mast Cells in Human Health and Diseases-3rd Edition” (https://www.mdpi.com/journal/ijms/special_issues/mast_cell) and may be obtained online without charge.
   
   Journal Impact Factor: 4.9
   
   Funding: “This work was supported by the National Institutes of Health (AR060913 and AR066811) and NASA (80NSSC20K0998).”
7. Hwang HS, Kim S, Darges S, Mudawar I.Computational investigation of flow condensation data from International Space Station microgravity and Earth gravity experiments.Int J Heat Mass Transf. 2026 May;258:128316.PI: I. MudawarJournal Impact Factor: 5.8
   
   Funding: “The authors acknowledge the support of the National Aeronautics and Space Administration (NASA) under grant no. 80NSSC22K0328.”
8. Liveretou C, Rivera J, Bardy M, Fernandez-Pello C, Gollner M, Etzenbach L, Thomsen M, Olson S, Ferkul P.Flame extinction of thermally thick PMMA in Earth gravity versus microgravity: A comparison of Earth and on-orbit space experiments.Fire Saf J. 2026 May;160:104625.PI: C. Fernandez-PelloJournal Impact Factor: 3.3
   
   Funding: “The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Christina Liveretou reports financial support was provided by NASA. Christina Liveretou reports financial support was provided by Alexander S Onassis Public Benefit Foundation. Jose Rivera reports financial support was provided by NASA. Sandra Olson reports financial support was provided by NASA. Paul Ferkul reports financial support was provided by NASA. Michael Gollner reports financial support was provided by NASA. Carlos Fernandez-Pello reports financial support was provided by NASA. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Acknowledgments This work was supported by NASA, USA Grant 80NSSC22K0582.”
9. Narayanan JK, Hylton S, Kassemi M, Hartwig JW, Mackey JR, Kharangate CR.CFD simulations for predicting vertical upflow liquid nitrogen transfer line chilldown process using a 3D two-phase flow mixture model.Int J Heat Mass Transf. 2026 May;258:128295.PI: C.R. KharangateJournal Impact Factor: 5.8
   
   Funding: “The authors are grateful for the financial support of the National Aeronautics and Space Administration (NASA), USA under Grant no. 80NSSC22M0056. The authors also acknowledge the computational support provided by High Performance Computing (HPC) cluster at Case Western Reserve University.”

Other papers of interest:

1. Wexler DB, Robinette MB, Coble CW, Coste A, Hoffman T, Danielson R.Hearing assessments and tympanometry in NASA astronauts on the International Space Station.Aerosp Med Hum Perform. 2025 Jan 1;97(1):26-35.Note: ISS results.
2. Al-Ahmadi W, Barnawi R, Hitti EG, Khabar KSA.Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model.Science Advances. 2026 Jan 2;12(1):eadw7832.Note: From the introduction: “In this study, we investigated global gene expression alterations at the cellular level in ISS and their functional and molecular network attributes and applied available machine learning (ML) programs for potential associations with health, disease, and therapy. These detailed analyses were performed with the monocytic-macrophage leukemia line, THP-1, a highly plastic myeloid cell line capable of modeling immune reprogramming and stress-response transcriptional activity.” This article may be obtained online without charge.
3. Kubota K.The missing discipline in space health operations: Nursing as mission assurance.Life Sci Space Res. 2025 Dec 31. Online ahead of print.
4. Li J, Gan Y, Sima Y, Hu J.Spaceflight noise effects on human performance in a microgravity environment.Aerosp Med Hum Perform. 2026 Jan 1;97(1):36-41.Note: From the abstract: “Experiments were conducted involving simulated space station warning interface alarm tasks and manual rendezvous and docking tasks in a virtual reality condition, with 30 volunteers who had normal hearing and were positioned in a head-down posture. The noise from the spacecraft was recorded from the Tiangong space station to create four distinct noise intensity levels. These levels were designed to simulate typical noise scenarios across various functional modules.”
5. Magni P, Ricci G, Narici M, Ferranti F.Impact of spaceflight on endocrine, metabolic and kidney function: Current evidence, open issues, and potential countermeasures.BMC Biol. 2025 Dec 29;23(1):365. Review.Note: This article may be obtained online without charge.
6. Tsiara AA, Farsadaki V.From fruit flies to genomics: Seventy-five years of unraveling spaceflight’s impact on life.JMASMR. 2025 Nov 26;1(1):8-19. Review.Note: This article may be obtained online without charge.
7. Van Hoy SE.Environmental carbon dioxide and temperature effects on sleep quality during space analogs.Aerosp Med Hum Perform. 2026 Jan 1;97(1):11-9.Note: This article may be obtained online without charge.
8. Das G, Vera Gonzalez AA, Choi D, Chhabra A, Kim D, Jayne BC.From nature to robots: A comprehensive survey on lizard-inspired robotics for ground and space exploration.Bioinspiration & Biomimetics. 2025 Dec 10. Online ahead of print.Note: This article may be obtained online without charge.
9. Bang SH, Hwang S, Choi SY, Kim HJ, Kim JH, Lee SH, Lee JW, Son KH.Enhanced ciliogenesis of human bronchial epithelial cells by simulated microgravity.Life (Basel). 2025 Dec 5;15(12):1864.Note: A 3D clinostat was used in this study to simulate microgravity. This article is part of Section “Astrobiology” (https://www.mdpi.com/journal/life/sections/astrobiology) and may be obtained online without charge.
10. Crambert A, de Regloix SB, Haen P, Morvan J-B, Caruhel J-B.Early aeromedical evacuation for orbital emphysema after zygoma and orbital floor fractures.Aerosp Med Hum Perform. 2026 Jan 1;97(1):55-9.Note: This article may be obtained online without charge.
11. Ochoa MI, Cao X, Reed MS, Matkovic E, Zeng W, Poore SO, Pogue BW.Imaging lymphatic function and inflammation response through hypoxia via endogenous biomarker.J Biomed Opt. 2025 Dec 29;31(1):016003.Note: This article may be obtained online without charge.
12. Shafaghat A.Space habitation: Machine learning based evaluation and optimization of critical parameters affecting sustainable space habitats.Space Habitation. 2026 Mar;2(1):100044.
13. Soilleux RJ, Lamontagne M.Chapter 1 – Orbital space settlements.In: Johnson L, Roy K, eds. Interstellar Travel. Elsevier, 2026. p. 1-28.
14. Twardowska K, Bortnowschi M, Skert R, Lee Y-H, Rafferty G, Pollock R.Cardiovascular effects of hypercapnia during lower body negative pressure and head-up tilt.Aerosp Med Hum Perform. 2026 Jan 1;97(1):3-10.
15. Biswas A.Chapter 21 – Bacterial adaptation to radiation: Challenges and opportunities.In: Kumar A, edr. Microbial Stress Survival. Academic Press, 2026. p. 453-75.
16. Kamal KY, Trombetta-Lima M, Lam K, Davis K, Jorgensen B, Thomsen C, Abdalla A, Lawler JM, Selsby JT.Chapter 2 – Skeletal muscle adaptations to spaceflight: Mechanisms and countermeasures.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 15-28.
17. Guo Y, Ong J, Waisberg E, Lee AG.Chapter 5 – Spaceflight-associated neuro-ocular syndrome.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 57-65.
18. O’Leary KS, Güner ZM, Mathyk B, Erenler F.Chapter 8 – Metabolic and endocrine changes in spaceflight.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 121-38.
19. D’Urbano J, Mushtaq S.Chapter 9 – Reproduction and obstetrics in space.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 139-53.
20. Gharahdaghi N, Laurence A.Chapter 10 – Immunometabolism in space.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 155-71.
21. Cools B, Vinken M.Chapter 11 – Effects of altered gravity on the liver.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 173-81.
22. Otsuka K, Cornelissen G, Beaty LA, Mukai C.Chapter 13 – Circadian rhythm changes in space.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 201-25.
23. Pradeep N, Green SJ, Chaudhary A.Chapter 16 – Gut microbiota and intervention of probiotics in spaceflight.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 267-84.
24. McBeth PB, Moore RWJ.Chapter 19 – Ultrasound in space.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 309-18.
25. Viera-Catota C, Chile-Miranda S, Villavicencio D, Haro-Vinueza A, Benavides-Almeida A, Perrier Q, Billings B, Koirala S, Pazmiño C, Dirani M, Lopez C, Salazar F, Guaillas A, Mitra K, Caicedo A.Chapter 21 – Regenerative medicine in space.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 325-40.
26. Clark KBChapter 22 – Digital clinicians in spaceflight and off-Earth habitation.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 341-50.
27. Piekarz KM.Chapter 28 – Organoid research in space for human health.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 425-34.
28. Waisberg E, Ong J, Lee AG.Chapter 29 – Open science in space medicine: Perspectives following the White House Office of Science and Technology Policy Open Science sessions for early career researchers.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 435-7.
29. Rivolta M, Ong J, Waisberg E, Zaman N, Stanwyck L, Sarker P, Tavakkoli A, Lee AG.Chapter 30 – Eye tracking during spaceflight: Current technology and future directions for spaceflight-associated neuro-ocular syndrome.In: Waisberg E, Ong J, Lee AG, eds. Fundamentals of Space Medicine and Clinical Technology. Academic Press, 2026. p. 435-7.

Astrobiology, space biology, space medicine, microgravity, NASA,