NASA Spaceline Current Awareness List #1,148 9 May 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Lee SMC, Miller A, Ribeiro LC, Rosenberg M, Miller CA, Laurie SS, Young M, Lytle JR, Kofman I, Clement G, Wood S, Rukavishnikov I, Kitov V, Kozlovskaya I, Tomilovskaya E, Reschke M, Macias BR.Cardiovascular responses to standing with and without lower body compression garments after long-duration spaceflight.J Appl Physiol (1985). 2025 May 8. Online ahead of print.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.3
   
   Funding: “The authors thank the cosmonauts and astronauts who volunteered to participate in these studies; the staff of the NASA JSC Cardiovascular and Vision Laboratory, the NASA JSC Neuroscience Laboratory, and the Institute of Biomedical Problems who coordinated the research activities, collected the data, and summarized the results; the NASA and Russian ground support and medical teams who made these tests in the field possible; and the Research Operations Integration Element for overall coordination of scheduling of data collection sessions. Ms. Sarah Pickering was instrumental in the editing and formatting of the final manuscript. This research was funded by NASA’s Human Research Program and the Russian Academy of Sciences (FMFR-2024-0033). Part of this data was collected under the Standard Measures Cross-Cutting Project of NASA’s Human Research Program.”
2. Warthen KG, Sater SH, Kramer LA, Hasan KM, Williams MA, Young M, Macias BR, Laurie SS, Martin BA.Brain and cerebrospinal fluid 3D center of mass shift after spaceflight.npj Microgravity. 2025 May 8;11(1):14.PI: B.A. MartinNote: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This study was supported by grant 80NSSC22K0023 through the Human Research Program of the National Aeronautics and Space Administration (NASA).”
3. Colorado AA, Gutierrez CL, Nelman-Gonzalez M, Marshall GD, Mccoy JT, Crucian BE.Hazards of lunar surface exploration: Determining the immunogenicity/allergenicity of lunar dust.Front Immunol. 2025 May 8;16:1539163.Note: From the abstract: “Our laboratory was officially approved for receipt of actual lunar dust samples from the Apollo 16 mission from NASA. These samples were used to complete the proposed set of in vitro cell culture experiments, using human peripheral blood mononuclear cells (PBMC) from healthy individuals, and basophils and eosinophil cell lines.” This article is part of Research Topic “Exploring Frontiers: Astroparticle, Space Science and Public Health for Future Crewed Space Missions” (https://www.frontiersin.org/research-topics/63490/exploring-frontiers-astroparticle-space-science-and-public-health-for-future-crewed-space-missions/overview). The Research Topic also includes articles from previous Current Awareness Lists #993 https://doi.org/10.3389/fpubh.2022.862598, #1,027 https://doi.org/10.3389/fspas.2022.949432, #1,049 https://doi.org/10.3389/fspas.2023.1117811, #1,124 https://doi.org/10.3389/fphys.2024.1486767, #1,127 https://doi.org/10.3389/fphys.2024.1482860, #1,137 https://doi.org/10.3389/fimmu.2025.1538421, and #1,146 https://doi.org/10.3389/fphys.2025.1558625. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.7
   
   Funding: “This work was supported by 2019 HERO 80JSC019N0001-FLAGSHIP & OMNIBUS: Human Research Program Crew Health. Appendix A&B.”
4. Abe J, Chau K, Mojiri A, Wang G, Oikawa M, Samanthapudi VSK, Osborn AM, Ostos-Mendoza KC, Mariscal-Reyes KN, Mathur T, Jain A, Herrmann J, Yusuf SW, Krishnan S, Deswal A, Lin SH, Kotla S, Cooke JP, Le N-T.Impacts of radiation on metabolism and vascular cell senescence.Antioxid Redox Signal. 2025 Apr 16. Review. Online ahead of print.PI: A. JainJournal Impact Factor: 5.9
   
   Funding: “This study received partial support from the National Institutes of Health (NIH) for N.-T.L. (HL157790, HL149303, HL163857, HL134740), J.P.C. (HL148338, HL157790), and J.A. (HL149303, AI156921). Additional funding was provided by NASA, BARDA, and the USFDA (Contract No. 80ARC023CA002). J.A. and Schadler were also supported by the Cancer Prevention and Research Institute of Texas (CPRIT, RP190256). The study was further supported by the NIH NHLBI (Award No. R01HL157790), an NSF CAREER Award (No. 1944322) to A.J., and an Institutional Research Grant (IRG) Program from the University of Texas MD Anderson Cancer Center to S.K. G.W. received support from the National Institute of General Medical Sciences (NIGMS, R35GM150460).”
5. Harrington J, Cheburkanov V, Kizilov M, Kulagin I, Petrov GI, Yakovlev VV.Highly sensitive, low-cost deep-UV resonant Raman microspectroscopy systems.Chemistry-Methods. 2025 Apr 21;2500006. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 6.1
   
   Funding: “J.T.H. received funding support via the SMART Scholarship-for-Service Program. V.V.Y. received partial funding support from the Air Force Office of Scientific Research (AFOSR) (grantsFA9550-20-1-0366, FA-9555-23-1-0599), the National Institutes of Health (NIH) (grants R01GM127696, R01GM152633, R21GM142107, R21CA269099), and NASA, BARDA, NIH, and USFDA, under Contract/Agreement No. 80ARC023CA002.”

Other papers of interest:

1. Baselet B, Miranda S, Rehnberg E, Van Rompay C, Baatout S, Tabury K.Chapter 30 – Cardiovascular diseases in spaceflight.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press, 2025. p. 467-80.
2. Bélanger Nzakimuena C, Masís Solano M, Marcotte-Collard R, Lesk MR, Costantino S.Spatial and temporal changes in choroid morphology associated with long-duration spaceflight.Invest Ophthalmol Vis Sci. 2025 May 1;66(5):17.Note: This article may be obtained online without charge.
3. Kapoor P, Yadav R, Agrawal N, Gaur S, Arora R.Long duration space missions: Challenges and prospects in sustaining humans in space: Advances in human physiology for sustaining outer space missions.Life Sci Space Res. 2025 May 7. Review. Online ahead of print.
4. Roberts DL.The new ‘right stuff’: What it takes to be an astronaut of the future.In: Cinelli I, Harris M, Beard B, eds. The Human Element in Advancing 21st-Century Space Exploration. Rijeka: IntechOpen, 2025.
5. Sharp J, Kelson J, South D, Saliba A, Kabir MA.Virtual reality and artificial intelligence as psychological countermeasures in space and other isolated and confined environments: A scoping review.Acta Astronaut. 2025 Jul;232:666-77.Note: From the abstract: “Spaceflight is an isolated and confined environment (ICE) that exposes astronauts to psychological hazards, such as stress, danger, and monotony. Virtual reality (VR) and artificial intelligence (AI) technologies can serve as psychological countermeasures as they can digitally simulate immersive environments, interactive companions, and therapeutic experiences. Our study employs a scoping literature review approach to identify what is currently known about the use and effectiveness of VR and AI-based interventions as psychological countermeasures to improve mood or emotional states in adults in space or other ICEs.”
6. Xavier JR, Chauhan OP, Shashikumar SH, Nagaraj R, Semwal AD.Food technologies for space missions.Life Sci Space Res. 2025 Aug;46:145-53. Review.
7. Anderson KD, Davis CA, Pickett SM, Pohlen MS.Evaluating large language models on aerospace medicine principles.Wilderness Environ Med. 2025 Apr 28;10806032251330628. Online ahead of print.
8. ElGindi M, Teo J.Exploring aging in microgravity.Nat Rev Bioeng. 2025 Apr 17.Note: This article is a Comment. From the abstract: “Microgravity accelerates ageing-like changes in cells and tissues. By integrating bioengineering technologies, researchers can uncover pathways to mitigate ageing and develop therapeutic interventions for age-related diseases both on Earth and in space.”
9. Wareing T, Stokes A, Crompton KE, Murphy K, Dawson J, Ugurluoglu YF, Richardson C, Li H, Prakash M, Wollman AJM.Microscopy with microfluidics in microgravity using FlightScope.npj Microgravity. 2025 May 6;11(1):13.Note: From the abstract: “With planned missions to the Moon and Mars, it has never been more important to study the impact of microgravity on biological organisms. Parabolic flights are one of the most accessible microgravity research platforms but present challenges: short periods of microgravity and aircraft vibration. Live-imaging is necessary to readout any real-time phenotypes so we developed FlightScope, a new microscopy and microfluidics platform to study dynamic cellular processes in microgravity.” This article may be obtained online without charge.
10. Marchant A, Ball N, Witchalls J, Wallwork SB, Waddington G.Ankle somatosensation and lower-limb neuromuscular function on a lunar gravity analogue.Brain Sciences. 2025 Apr 24;15(5):443.Note: This article is part of Section “Sensory and Motor Neuroscience” (https://www.mdpi.com/journal/brainsci/sections/Sensory_Motor_Neuroscience_) and may be obtained online without charge.
11. Migaki W, Doki S, Kanai N, Oi Y, Schastlivtseva D, Takahashi T, Fujii A, Hori D, Matsuzaki I, Sasahara S.How isolated and confined-environment missions shape human interactions: SIRIUS-21.Acta Astronaut. 2025 May 3. Online ahead of print.Note: From the abstract: “This study investigated the dynamics of human interactions among the crew participating in the 240-day closed experiment named SIRIUS-21 (Scientific International Research in Unique Terrestrial Station) in Moscow, Russia.”
12. Soryl A, Sandberg A.To seed or not to seed: Estimating the ethical value of directed panspermia.Acta Astronaut. 2025 Jul;232:397-404.Note: From the abstract: “Directed panspermia involves the deliberate spread of life between planets by intelligent actors. While it was originally proposed to explain the origin of life on Earth, recent advancements in space and bio-technology suggest that humans could soon attempt this – and perhaps even succeed. Biocentric ethical theories support attempting directed panspermia to increase life’s cosmic abundance and to protect it from possible extinction risks on Earth. However, if this project succeeds and sentient life evolves within the resulting biospheres, it also carries the moral risk of creating astronomical levels of suffering. Taking into account epistemic and normative uncertainty, the potential irreversibility of our actions, and the lack of global coordination on the development and implementation of space technology, we argue for a temporary moratorium on directed panspermia – at least, until we can predict its long-term outcomes to ensure that whatever decision we make is ethically robust.”
13. Wang Y, Li Z, Su R, Wang X, Gao S, Wang Y, Zhang Y, Su Y.Effects of exercise intervention on executive function in 90-day head-down bedrest.Acta Astronaut. 2025 Jul;232:23-31.
14. Wochyński Z. Evaluation of selected elements of fitness and physiological diagnostics of military pilots as a factor in flights safety.Front Physiol. 2025 May 1;16:1558786.Note: This article is part of Research Topic “Sex-based Differences in Physiological Responses to Exercise and Environmental Stimuli” (https://www.frontiersin.org/research-topics/68727/sex-based-differences-in-physiological-responses-to-exercise-and-environmental-stimuli) and may be obtained online without charge.

astrobiology, ISS, Microgravity, space biology, space life science, space medicine,