synthetic life Archives

Motivation and conceptualization for engineering RNA origami-based hardware for synthetic cells. a) Biological cells function according to the central dogma (DNA serves as a template for RNA, and RNA directs protein synthesis), necessitating the involvement of numerous genes in the translational process. In contrast, a synthetic cell built upon RNA origami requires fewer components while maintaining evolvability. b) Mechanism of cotranscriptional RNA origami folding. A DNA template is transcribed by RNA polymerase, whereby the RNA folds up into tiles that self-assemble into higher-order RNA origami nanotubes inside synthetic cells. c) Information-function correlation. Mutations on the DNA template result in RNA origami nanotubes with different morphologies and functions. -- biorxiv.org

Biochemistry & Organic Chemistry, Biophysics, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Status Report

Genetic Encoding and Expression of RNA Origami Cytoskeletons in Synthetic Cells

by Keith CowingJune 20, 2024June 20, 2024

The central dogma at the core of molecular biology states that information flows from DNA to RNA and then to protein. Our research seeks to introduce a conceptually novel approach […]

synthetic life

Genetic Encoding and Expression of RNA Origami Cytoskeletons in Synthetic Cells

Astrobiology: Fifty Years After Viking: New Special Collection Available Now

Early Exploration Of The Scientific Discovery Space For The Habitable Worlds Observatory

The Ĝ Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. V. When Galaxies Glow with Industry

Astrochemistry: A Cosmic Recycling System In Action In The Helix Nebula

Spectral Energy Distribution Analysis For Habitable Worlds Observatory Target Stars