spliceosome Archives

Energetics associated with the occupancy of the K1 site and the position of the M2 ion. (A) Free energy surface of the concerted motions of Prp11 Lys10 and M2, with the initial PDB conformation marked by a yellow star. (B–D) Representative structures of three metastable states from metadynamics simulations. State 1 (B) represents a PDB-like arrangement where Lys10 (slate blue sticks) remains at the K1 site, and M2 (yellow sphere) is properly positioned at the U6 snRNA triple-helix (yellow cartoon). State 2 (C): Lys10 leaves the K1 site, allowing a K+ ion to occupy it and stabilize M2 in place. State 3 (D): M2 directly coordinates G52, losing its catalytic position and partially occupying the K1 site. -- PNAS

Astropharmacy / Biotechnology, Biochemistry & Organic Chemistry, Biophysics, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio, Status Report

Computational Chemistry And Supercomputers To Help Understand The Mechanisms Of Life

by Keith CowingApril 13, 2026April 13, 2026

A new study from the Italian Institute of Technology (IIT), in collaboration with Uppsala University (Sweden) and AstraZeneca, shows how computational chemistry and supercomputers can help scientists better understand the […]

spliceosome

Computational Chemistry And Supercomputers To Help Understand The Mechanisms Of Life

ALMA Central Molecular Zone Exploration Survey (ACES) I: Overview

RNA And Proteins Joined Up At The Origins Of Life: Persistence Is The Point

Selection For Growth Drives The Emergence Of Genetic Heredity In Protocells

NASA SMD ROSES-25 Amendment 65: New Opportunity: C.4 Planetary Science Enabling Facilities

TESS Photometry and Radial Velocity Analysis of the sub-Neptune Exoplanet π Mensae c and the Wider π Mensae Planetary System