exonuclease Archives

(a) MCM2-7 double-hexamer (DH). (b) DDK-activated MCM2-7 DH in complex with Sld3-Sld7. (c) CDK activity promotes recruitment of helicase activation factors GINS, Polε, Sld2, and Dpb11. (d) Sld2-GINSDpb11-Polε-induced MCM2-7 ATPase-dependent activity results in the splitting of the DH and a rotation of the two CMGE complexes against each other. (e) Mcm10 recruitment promotes DNA extrusion and complete separation of the two hexamers. (f) Extended unwinding promotes the recruitment of Tof1, part of the replication fork protection complex. Loading factors that do not form part of the replication fork are shown in grey. -- Nature

Pinpointing Where Cells First Begin Copying DNA

by Keith CowingJuly 25, 2026July 25, 2026

[Medical Research Council (MRC) Laboratory of Medical Sciences] Every time a cell divides, it must faithfully copy its entire genetic instruction manual. Errors during this process can damage the genome, […]

exonuclease

Pinpointing Where Cells First Begin Copying DNA

Why Europa’s Hidden Ocean May Be More Difficult To Reach Than Scientists Thought

Pinpointing Where Cells First Begin Copying DNA

Experimental Measurements of Benzene Ice Critical Saturation Ratios on Titan Tholins and Impact on the Microphysical Modeling of Titan’s South Polar Benzene Cloud

From Mars to Minas: Research Reclassifies Organisms That Thrive In Highly Saline Environments

Could Alien Signals Be Hiding On A Different Radio Channel?