![Overview of the PlainMap mapping workflow. PlainMap processes heterogeneous FASTQ input through header-based pairing inference, pilot subsampling and deterministic chunking, fastp preprocessing, mode-specific mapping, BAM processing, and summary-statistic generation. Optional outputs include mapDamage analyses and FASTQ files containing unmapped reads. -- [q-bio.GN]](https://i0.wp.com/astrobiology.com/wp-content/uploads/2026/09/PlainMap.png?resize=1200%2C719&ssl=1)
[q-bio.GN] Mapping sequencing reads to a reference genome requires preprocessing and alignment choices that can vary with library type, fragment length, sequencing platform, and reference genome.
bioinformatics
Posted inGenomics, Proteomics, Bioinformatics
A Genomic Catalog Of Earth’s Bacterial And Archaeal Symbionts
[Nature Biotechnology] Microbial symbiosis drives the functional and phylogenomic diversification of life on Earth yet remains underexplored because of culturing challenges.
Posted inGenomics, Proteomics, Bioinformatics
ExMODE: A Comprehensive Resource For Extremophile Genomic And Functional Exploration
[iMetaOmics] ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat-specific non-redundant genes, 5.25 million representative protein structures, 67,026 metagenome-assembled genomes (MAGs), and 164,132 […]
Posted inExtremeophiles and Extreme Environments
Antarctica Is Home To Microbes Found Nowhere Else On Earth
[CU Boulder] Scientists have often wondered about species that are unique to Antarctica. But the focus has mainly been on animals, like cute feathery penguins. But CIRES researchers wanted to […]
Posted inPlanetary Protection & Biosafety
Predicting Fungal Contaminants for Space Missions Using Proteome-Wide Screening for Protein Orthologs
[biorxiv.org]. Fungal contamination poses a growing threat to spacecraft integrity, crew health, and planetary protection efforts.
Posted inFossils & Paleontology
Where Was This Fossil 200 Million Years Ago?
[University of Barcelona] Calculating a fossil’s position throughout geological history is a complex process. In palaeontology and other disciplines, determining a location in the past is quite a challenge that […]
Posted inGenomics, Proteomics, Bioinformatics
Ocean World Genomics: Earth’s Deep Sea Is An Untapped Evolutionary Engine
[University of East Anglia Norwich] The deep-sea is a unique ‘evolutionary engine’ with one of the richest and most unexplored sources of genetic diversity on Earth, according to a major […]
Posted inOrigin & Evolution of Life
How Early RNA-based Life May Have Repaired Its Genome
[University of Notre Dame] In most modern cells, DNA stores the genetic blueprint, and relies on proteins to replicate, repair and build from those blueprints. At the same time, proteins […]
Posted inTricorders & Sensors
Tricorder Tech: Identifying Proteins, Molecule By Molecule
[Université de Genève] Proteins are responsible for most functions in the human body. However, their analysis, which is essential for understanding diseases, developing drugs, and discovering new biomarkers, remains highly […]
Posted inGenomics, Proteomics, Bioinformatics
BioBloom, A Method For Barcoded Saturation Mutagenesis Of An Entire Bacterial Genome
Editor’s note: As we expand outward from Earth to other worlds we are almost certainly going to encounter things we did not expect to find – things that are unlikely […]