NASA Astrobiology Program

The Origin, Extension, and Future of the “NASA Definition” of Life

By Keith Cowing
Status Report
Astrobiology via PubMed
January 28, 2026
Filed under , , , , ,
The Origin, Extension, and Future of the “NASA Definition” of Life
Using a NASA Tricorder to scan for life signs aka biosignatures – Astrobiology.com and Grok

The “NASA definition” enjoys broad popularity among scientists, particularly in the astrobiology community: life is “a self-sustained chemical system capable of Darwinian evolution.”

Imprecise and difficult to implement, it nevertheless captures important features of life interesting to researchers and public audiences. A product of the Exobiology Discipline Working Group, it received a four-sentence introduction in a book foreword by Gerald Joyce.

The only subsequent defense can be found in an online interview of Joyce. Additional commentary is limited, mostly critical, and occasionally incorrect. This article looks at the history of the definition and how it differs from earlier definitions of life as replication plus metabolism.

The NASA definition focuses attention on information, molecular mechanisms, and “Darwinian evolution” through generalizations of replication. It retains traditional ambiguity about metabolism related to concepts of “self,” “self-sustaining,” and “capable.” Understood in this context, the NASA definition identifies the current state of biology and suggests an agenda for future research.

A “NASA working definition” may be more usefully constructed as follows: NASA will recognize life in a self-sustained chemical system demonstrating evolution by natural selection.

Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻