SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasa.gov/tbp/spaceline.cfm. Please send any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Note: Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.
Papers deriving from NASA support:
1 Krishnavajhala A, Gingras MC, Santiago-Rodriguez TM, Chen Y, Bandaranaike D, Bhamidipati S, Qin X, Kottapalli K, Momin Z, Santhanam A, Walker K, Wang Q, Griffin SM, Masternak MM, Ross MC, Muzny D, Wu J, Urquieta E, Gibbs RA, Doddapaneni H.Microbial dynamics across commercial spaceflights of varying duration.iScience. 2026 Nov 20;29(11):117988.https://pubmed.ncbi.nlm.nih.gov/42964741Note: ISS results. This article may be obtained online without charge.Journal Impact Factor: 4.5Funding: “This study was funded (Grant# INN0010) by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. Single-cell libraries were prepared by the Single-Cell Geno mics Core at Baylor College of Medicine, which is supported with funding from the CPRIT RP200504 and P30CA125123.”
2 Callaway CW, Weissman AJ, Flickinger KL, Wu V, Monteleone J, DeMaio R, Hierro M, Neofes D, Ortega-Reyes O, Sheng T, Salinas M, Lerro P, Guyette FX, Gordon BDH, Mortreux M, Melanson K, Buysee DJ, Empey PE.Dexmedetomidine effects on metabolic rate over 5 days in humans.PLoS One. 2026 Oct 27;21(10):e0359711.https://pubmed.ncbi.nlm.nih.gov/42945316PIs: C.W. Callaway, K.L. FlickingerNote: This article may be obtained online without charge.Journal Impact Factor: Not available for this journalFunding: “This work was supported by National Aeronautics and Space Administration award NNX16AO69A to the Translational Research Institute for Space Health at the Baylor College of Medicine with subawards to CWC and KF (https://www.nasa.gov/hrp/the-translational-research-institute-for-space-health-trish/) and by National Institutes of Health S10 OD028540 to the University of Pittsburgh Small Molecule Biomarkers Core (https://www.biomarkers.pitt.edu).”
3 Ali S, Diaz BIM, Zhuang P, Greenberg Z, Zhang Y, Richards J, Carlos D, Countryman S, Leeuwenburgh C, Lee LP, He M.Extracellular vesicles for space biomedical research.J Extracell Vesicles. 2026 Nov 5;15(11):e70397.https://pubmed.ncbi.nlm.nih.gov/42988730Note: This article may be obtained online without charge.Journal Impact Factor: 21.7Funding: “We acknowledge funding support from NIH NIGMS 1R35GM133794 to Dr. Mei He and NIH NCATS 1UG3TR005829 to Dr. Mei He and Dr. Luke Lee. We also acknowledge the Space Act Agreement Annex KCA-4761-1between UF and NASA initiated by Dr. Rob Ferl. Dr. Ye Zhang, Jeffrey Richards, and Danny Carlos were supported by the NASA’s Division of Biological and Physical Sciences.”
4 Diak DM, Bustos-Lopez S, Gutierrez CL, Crucian BE, Mehta SK.Valacyclovir reduces inflammation and IgG subclass activation by suppressing herpesvirus reactivation in antarctic expeditioners.Front Immunol. 2026 Oct 18;17:1957541.https://doi.org/10.3389/fimmu.2026.1957541PI: S.K. MehtaNote: This article is part of Research Topic “Interplay between host-immune response and herpesvirus infection” (https://www.frontiersin.org/research-topics/76186/interplay-between-host-immune-response-and-herpesvirus-infection) and may be obtained online without charge.Journal Impact Factor: 7.0Funding: “The author(s) declared that financial support was received for this work and/or its publication. The study was funded as an augment to the original research proposal by Human Research Program of NASA grant #80JSC017N0001-OMNIBUS.”
5 Gupta J, Mozneb M, Moses J, Sharma A.Bioengineering technologies for enabling biomedical research in space.Front Bioeng Biotechnol. 2026 Oct 12;14:1915463. Review.https://pubmed.ncbi.nlm.nih.gov/42948275Note: This article is part of Research Topic “Advancing Disease Modeling and Therapy with Organoids and Organ-on-a-Chip” (https://www.frontiersin.org/research-topics/69760/advancing-disease-modeling-and-therapy-with-organoids-and-organ-on-a-chip). The Research Topic also includes an article from previous Current Awareness List #1,220 https://doi.org/10.3389/fbioe.2026.1927687. This article may be obtained online without charge.Journal Impact Factor: 5.8Funding: “This work was supported by an In- Space Production Award (InSPA) from NASA (NNJ13ZBG001N). AS is supported by an Igniting Innovation Award from the International Space Station National Laboratory, a California Institute for Regenerative Medicine Infrastructure Award INFR6.2-15475, and an NIH Chips in Space 2.0 Award 1UG3AG099469-01.”
6 Lundholm KR, Satterfield BC, Banks S, Liu PY, Kombala CJ, Hurtado-Alvarado G, Greer AJ, Muck RA, Layton MA, Du D, Gaddameedhi S, Van Dongen HPA.Biological mechanisms underlying the adverse health consequences of human circadian misalignment from night shift work.Curr Sleep Med Rep. 2026 Oct 23;12(1):51. Review.https://pubmed.ncbi.nlm.nih.gov/42927053Note: This article may be obtained online without charge.Journal Impact Factor: 3.3Funding: “This work was supported by NIH grants R01HL177106 and R01ES030113, and in part by NASA Space Biology ROSES Program NNH24ZDA001N-CIBS Washington State BioS-ENDURES Consortium under contract 80NSSC25M7148.”
7 Warren E, Wu A, Ramirez L, Huang Y, Amelung C, Saxonhouse S, Gerecht S.A retinal matrix stiffening model reveals FAK-dependent mechanotransduction in pericytes underlies vascular destabilization.Adv Mater. 2026 Nov 2. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/42973071PI: S. GerechtNote: This article may be obtained online without charge.Journal Impact Factor: 29. 1Funding: “This material is based upon work supported in part by the Air Force Office of Scientific Research under award number FA9550-23-F-0014 in the amount of $129 600 (to E.W.). Y.H. is supported by the American Heart Association, and C.A. is supported by the National Science Foundation Graduate Research Fellowship Program (NSF GRFP). We acknowledge support from the Duke Cancer Institute as part of the P30 Cancer Center Support Grant (Grant ID: P30 CA014236). This work was supported by Duke Science and Technology, Air Force Office of Scientific ResearchFA9550-26-1-B020, SNT0101 from the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A and by National Institutes of Health R01 EY035853 (to S.G.).”
8 Wozniak KJ, Corver J, Kuijper EJ, Smits WK, Britton RA.Genome sequence of Clostridioides difficile PRB1128, a RT023 strain containing a mobile genetic element allowing for xylitol utilization.Microbiol Resour Announc. 2026 Oct 29;e0090726. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/42954463PI: K.J. WozniakNote: This article may be obtained online without charge.Journal Impact Factor: 0.6Funding: “This work was supported by U19AI157981 and R01AI123278 to R.A.B. K.J.W. was supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A. K.J.W. was also supported by a training fellowship from the Gulf Coast Consortia, on the Antimicrobial Resistance Training Program in the Texas Medical Center, (National Institute of Allergy and Infectious Diseases Grant no. T32AI179595).”
__________________________________________________
Other papers of interest:
1 Ciaccio EJ, Talke M, Peters NS, Schwartz SM, Coromilas J, Yarmohammadi H, Biviano AB.Microgravity and cardiac electrophysiology: Autonomic remodeling, arrhythmogenesis, and implications for long-duration spaceflight.Heart Rhythm. 2026 Nov 4. Review. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/42982387
2 Burnapp H.From Sputnik I to SpaceX: How the governance of space activities is evolving from a state-centred legal order to actor-centred norms of behavior.Acta Astronaut. 2026 Nov 4. Online ahead of print.https://doi.org/10.1016/j.actaastro.2026.10.050
3 Latham AP, Skountzos EN, Lantin S, Quarton T, Ravichandran A, Lee JA, Lawson JW.Toward resolving gravitational effects on microbial growth with computer simulations.Life Sci Space Res. 2026 Oct 31. Online ahead of print.https://doi.org/10.1016/j.lssr.2026.10.011Note: “From the abstract: As the duration of space flights increases, so does the need to optimize off-planet microbial growth. Microbes can both be unintentionally brought into space and cause human disease or be intentionally harnessed for on-site bioengineering functions. However, optimizing microbial growth is challenging due to an insufficient understanding of how microbial communities are affected by the extraterrestrial environment. To address this gap, we have developed an updated model for cell growth in microgravity (CFD-DEM Artificial Microgravity Developments for Living Ecosystem Simulation – CAMDLES2).”
4 Kazmi S, Mosaddeghi-Heris R, Shahabifard H, Karimi H, Shariati A, Motlagh Asghari K, Sadigh-Eteghad S, Hamblin MR, Mahmoudi J, Farajdokht F.Transcranial photobiomodulation mitigates anxiety and depression-like behavior by modulation of mitochondrial and neuroinflammatory pathways in a mouse model of simulated microgravity.J Photochem Photobiol B. 2026 Oct 25;284:113583.https://pubmed.ncbi.nlm.nih.gov/42962388Note: From the abstract: “Mental health is a major concern for astronauts due to the high risk of anxiety and depression caused by prolonged exposure to microgravity and the stresses of spaceflight. Existing pharmacological treatments are inadequate for space missions, emphasizing the necessity for safe, noninvasive interventions. This study explored the therapeutic efficacy of transcranial photobiomodulation (tPBM) using near-infrared (NIR) light therapy on mood regulation and the neurobiological mechanisms in mice subjected to simulated microgravity. Male mice were divided into three groups: a control group, a hindlimb unloading (HU) group subjected to 28 days of unloading, and an HU + tPBM group receiving daily tPBM treatment at 810 nm.”
5 Windisch J, Richter RF, von Witzleben M, Dani F, Greil C, Duin S, Lode A, Gelinsky M.Characterizing the extrusion bioprinting process and microalgal photosynthetic efficiency in bioprinted constructs during parabolic flights.npj Microgravity. 2026 Oct 30;12(1):90.https://pubmed.ncbi.nlm.nih.gov/42963346Note: This article may be obtained online without charge.
6 Bartlett MF, Ren J, Sarma S, MacNamara JP, Brazile TL, Wakeham DJ, Hearon CM, Jr., Lutz K, Fadel PJ, Haykowsky MJ, Levine BD, Zaha V, Nelson MD.Skeletal muscle oxidative capacity and tissue composition in heart failure with preserved ejection fraction.J Appl Physiol (1985). 2026 Nov 1;141(5):1240-51.https://pubmed.ncbi.nlm.nih.gov/42932891Note: This article may be obtained online without charge.
7 Jaster JH.Breathing may be primarily driven by the unceasing rotation of residual gravitational ischemia in the brain-‘skull-trapped’ regions of reduced oxygen tension.J Neurophysiol. 2026 Nov 2. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/42973070Note: This article may be obtained online without charge.
8 Bashir M, Jubouri M, Gaffney CJ, Grewal N, Mohammed I, Abdelhaliem A, Piffaretti G, Teraa M, Bailey DM, Williams IM.Beyond anatomy in uncomplicated type B aortic dissection: Hypoxia, physiological reserve, and the next generation of intelligent endovascular devices.Med Devices (Auckl). 2026 Oct 20;19:636743. Review.https://pubmed.ncbi.nlm.nih.gov/42979179Note: This article may be obtained online without charge.
9 Chen Z, Marjan T, Lu X, Mertens NE, Vesy K, Stornello DE, Markworth JF, Qazi TH.Programmable microgel degradation in dynamic granular hydrogels guides extracellular matrix assembly during tissue repair.Adv Mater. 2026 Oct 29. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/42954782Note: This article may be obtained online without charge.
10 Denolle T, Gebara N, Bertolino J, Bachetti K, Baguet JP, Boivin JM, Boutouyrie P, Derobertmasure A, Evrard AS, Lamirault G, Lopez-Sublet M, Persu A, Renaudineau E, Sosner P, Stoenoiu MS, Vaisse B, Duly Bouhanick B.Environmental and psychosocial factors in hypertension: An emerging landscape of cardiovascular risk.Blood Press. 2026 Oct 28;35(1):2743395. Review.https://pubmed.ncbi.nlm.nih.gov/42948965Note: This article may be obtained online without charge.
11 Fukazawa A, Hotta N, Hori A, Kim HK, Iwamoto GA, Smith SA, Vongpatanasin W, Mizuno M.Skeletal muscle-innervating small dorsal root ganglion neurons exhibit greater mechanosensitivity and responsiveness to yoda-1 in rats.Am J Physiol Cell Physiol. 2026 Oct 13. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/42932973Note: This article may be obtained online without charge.
12 Gritsenko V, Kunavar T, Jamšek M, Yakovenko S, White O, Babič J.Dissociation of gravity and limb dynamics in motor control.Proc Natl Acad Sci USA. 2026 Nov 10;123(45):e2613283123.https://pubmed.ncbi.nlm.nih.gov/42975927Note: From the abstract: “Human movements remain accurate across substantial variations in mechanical loading, yet how the nervous system anticipates and compensates for intrinsic and extrinsic forces when generating muscle commands remains unresolved. Because the forces acting on the body are complex and nonlinear, dynamical modeling provides a powerful framework for identifying the computations underlying motor control. Here, we exploited parabolic flight to dissociate gravitational loading from intrinsic limb dynamics and directly test how these mechanical components are represented in motor commands.”
13 Ha K, Hu X, Liu D, Zhang G, Zhang S, Zhao S, Tu L, Jiang T, Ma X, Fan Q, Liu J, Zhang C, Shi H, Xu J, Cui J.Application of radial artery signal characteristics in long-term head-down bedrest experimental cardiovascular status assessment.Front Physiol. 2026;17:1961052.https://pubmed.ncbi.nlm.nih.gov/42984580Note: This article may be obtained online without charge.
14 Tavakol DN, Mendonca D, Baldassarri I, Maletic-Savatic M, Vunjak-Novakovic G.Organoids and organs-on-a-chip as new approach methodologies at the convergence of cell biology and bioengineering.Cell Stem Cell. 2026 Nov 5;33(11):1753-67.https://doi.org/10.1016/j.stem.2026.10.003
Astrobiology, space life science, space medicine, microgravity, space biology,
