NASA Spaceline Current Awareness List #1,123 8 November 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Hayes J, Fairchild B, Nichols K, Jayasuria J, Mehta RK.Selective sensorimotor impairments with mental fatigue associated with G-transitions during and after spaceflight.Proc Hum Factors Ergon Soc Annu Meet. 2024;10711813241275073.PI: R.K. MehtaNote: This article is a meeting proceedings that published in peer-reviewed Sage Journals. From the abstract: “Decrements in sensorimotor performance due to vestibular challenges associated with spaceflight are well characterized, and these impairments pose a significant risk to astronaut safety and mission success. However, the impact of fatigue on this impairment is unknown. We hypothesized that the interaction of fatigue and vestibular impairment would lead to greater-than-additive detriments to static and dynamic balance. Thirteen subjects (9 m/4 f) completed a series of sensorimotor tests (static and dynamic tasks, with and without galvanic vestibular stimulation) before and after a fatigue-induction task.” This article may be obtained online without charge.
   
   Journal Impact Factor: 3.598
   
   Funding: NASA grant #80NSSC24K0485.
2. Hughes-Fulford M, Carroll DJ, Allaway HCM, Dunbar BJ, Sawyer AJ.Women in space: A review of known physiological adaptations and health perspectives.Exp Physiol. 2024 Nov 2. Review. Online ahead of print.PIs: H.C.M. Allaway, B.J. DunbarNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.6
   
   Funding: “Translational Research Institute for Space Health, Grant/Award Number: NNX16AO69A.”
3. Abercromby A, Baumann D, Berdich D, Broyan J, McCoy T, Watkins S, Zapp N.NASA’s top human system research and technology needs for Mars.Acta Astronaut. 2024 Nov 11. Online ahead of print.Note: From the abstract: “NASA is working with industry and international partners to return humans to the Moon and to eventually enable humans to explore Mars. Within NASA, several organizations work together to identify, prioritize, fund, execute, and operationalize the research and technology development (R&TD) that will be necessary to enable crew health and performance (CHP) during these future missions. These organizations include flight programs, the Health and Medical Technical Authority (HMTA), the Human Research Program, the Space Technology Mission Directorate, System Capability Leadership Teams, and other organizations, many of which existed for several years prior to the creation of the Moon-to-Mars (M2M) Program Office in 2023.”
   
   Journal Impact Factor: 3.1
   
   Funding: The authors are affiliated with the National Aeronautics and Space Administration.

Other papers of interest:

1. Joe B.Spaceflight associated neuro-ocular syndrome: Connections with terrestrial eye and brain disorders.Front Ophthalmol. 2024 Oct 17;4:1487992.Note: This article is a perspective and is part of Research Topic “Space Ophthalmology: Assessment, Treatment and Mitigation of Spaceflight Associated Neuroocular Syndrome (SANS)” (https://www.frontiersin.org/research-topics/58922/space-ophthalmology-assessment-treatment-and-mitigation-of-spaceflight-associated-neuroocular-syndrome-sans#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,068 https://doi.org/10.3389/fopht.2023.1229748 and #1,074 https://doi.org/10.3389/fopht.2023.1279831. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
2. Riski AD.Effects of microgravity on muscle and bone health in astronauts during space missions: Preventive procedures and medical interventions.KJAsEM. 2024;34(3):89-95. Review.Note: This article may be obtained online without charge.
3. Wostyn P, Mader TH, Gibson CR, Nedergaard M.New insights in brain-to-eye transport: Can excess cerebrospinal fluid in astronauts escape into the eye?Eye (Lond). 2024 Nov 4. Online ahead of print.
4. Post TE, Denney C, Cohen A, Jordan J, Limper U.Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research.Br J Clin Pharmacol. 2024;1-4. Review.Note: This article may be obtained online without charge.
5. Cao S, Wang Y, Zhang Y, Ren J, Fan B, Deng Y, Yin W.Naringenin can inhibit the pyroptosis of osteoblasts by activating the Nrf2/HO-1 signaling pathway and alleviate the differentiation disorder of osteoblasts caused by microgravity.J Agric Food Chem. 2024 Nov 6. Online ahead of print.Note: Hindlimb unloading study. This article may be obtained online without charge.
6. Zhang Y, Wang W, Zhang M, Zhang B, Gao S, Hao M, Zhou D, Zhao L, Reitz G, Sun Y.Using single-sample networks and genetic algorithms to identify radiation-responsive genes in rice affected by heavy ions of the galactic cosmic radiation with different LET values.Front Plant Sci. 2024 Nov 7;15:1457587.Note: This article may be obtained online without charge.
7. Anello P, Esposito G.Biological effects in normal human fibroblasts following chronic and acute irradiation with both low- and high-LET radiation.Front Public Health. 2024 Oct 12;12:1404748.Note: This article is part of Research Topic “Research on Low Dose Ionizing Radiation Health Effects” (https://www.frontiersin.org/research-topics/52678/research-on-low-dose-ionizing-radiation-health-effects/overview) and may be obtained online without charge.
8. Keskin I, Karabulut S, Kaplan AA, Alagöz M, Akdeniz M, Tüfekci KK, Davis DL, Kaplan S.Preliminary study on the impact of 900MHz radiation on human sperm: An in vitro molecular approach.Reprod Toxicol. 2024 Dec;130:108744.
9. van den Nieuwenhof DWA, Moroni L, Chou J, Hinkelbein J.Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: A narrative review.npj Microgravity. 2024 Nov 6;10(1):102. Review.Note: This article may be obtained online without charge.
10. Kendal E.A duty to enhance? Genetic engineering for the human Mars settlement.Monash Bioeth Rev. 2024 Nov 1. Online ahead of print.Note: From the abstract: “Humans living off-world will face numerous physical, psychological and social challenges and are likely to suffer negative health effects due to their lack of evolutionary adaptation to space environments. While some of the necessary adaptations may develop naturally over many generations, genetic technologies could be used to speed this process along, potentially improving the wellbeing of early space settlers and their offspring.”
11. de Souza ÁC, Mencalha AL, Fonseca ASD, de Paoli F.Necroptosis as a consequence of photodynamic therapy in tumor cells.Lasers Med Sci. 2024 Nov 1;39(1):267. Review.Note: From the abstract: “Photodynamic therapy (PDT) is an alternative to cancer treatment, demonstrating selectivity and significant cytotoxicity on malignant tissues. Such therapy involves two nontoxic components: photosensitizer (PS) and non-ionizing radiation. In optimal dosage combinations, PDT causes cellular and tissue effects by oxygen-dependent processes, leading tumor cells to regulated cell death pathways. Regulated necrosis, called necroptosis, can be triggered by PDT and is characterized by caspase-8 inhibition and RIPK1, RIPK3, and MLKL activities, leading to plasma membrane pores formation with subsequent cellular content release into the extracellular space. For this review, studies accessed by PubMed describing the relation between necroptosis and PDT were summarized.”
12. Fard MRB, Protocol-Guzmán NS, Chan J, Read AT, Feola A, Stamer WD, John SWM, Ethier CR, Sappington RM.A comprehensive protocol for microbead-induced ocular hypertension in mice.Methods Mol Biol. 2025;2858:243-64.
13. Fayet-Moore F, Robinson SR.A breath of fresh air: Perspectives on inhaled nutrients and bacteria to improve human health.Adv Nutr. 2024 Oct 30;100333. Online ahead of print.
14. Hattori T, Hishii-Higuchi S, Inoue H, Kato T, Hashimoto T, Wakabayashi K, Hoson T, Soga K.Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls.Life Sci Space Res. 2024 Nov 6. Online ahead of print.
15. Li X, Liu J, Li Z, Chen A, Zhao R, Xu S, Sheng X.Emerging Arabidopsis roots exhibit hypersensitive gravitropism associated with distinctive auxin synthesis and polar transport within the elongation zone.Plant Physiol Biochem. 2024 Nov 2;109257.
16. Cockell CS, Green DA, Caplin N, Grenouilleau J, McDonald FE, Calvaruso M, Billi D, Cullen DC, Davey MP, De Micco V, Elsaesser A, Etheridge T, Gläßer C, Hellweg CE, Ilea CS, Lecocq A, Leys N, Martin-Torres J, Nazarious M, Pacelli C, Przybyla C, Rabbow E, Brown K, Soria-Salinas A, Szewczyk N, Tinganelli W, Tranfield EM, de Vera JP, Verseux C.BioMoon: A concept for a mission to advance space life sciences and astrobiology on the Moon.Discover Space. 2024 Oct 28;128(1):5.Note: This article may be obtained online without charge.
17. Makani A, Saryazdi R, Givetash S, Keshavarz B.The presence of an avatar can reduce cybersickness in virtual reality.Virtual Real. 2024 Oct 30;28(4):163Note: From the abstract: “This paper reviews the current views on formation, development, and activity of the connectome under the influence of gravity.” This article may be obtained online without charge.
18. Chen G, Huang Y, Huang C, Li L, Pang J, Li H, Zhang W.Decompression sickness-induced skeletal muscle injury: An animal model and pathological analysis.Front Vet Sci. 2024 Sep 12;11:1431110.Note: This article is a perspective and is part of Research Topic “Exploring Genetic and Environmental Factors in Skeletal Muscle Development” (https://www.frontiersin.org/research-topics/61723/exploring-genetic-and-environmental-factors-in-skeletal-muscle-development/overview) and may be obtained online without charge.
19. Zhou M, Zhu B, Qing L, Zhou Y, Yi H, Wang Y, Zhang K, Xu W.Body hydration status and decompression sickness.J Occup Environ Med. 2024;41(7):834-40.Note: This article may be obtained online without charge.
20. Jang J.Current status and prospects of Korea’s aerospace medicine.KJAsEM. 2024;34(3):78-81.Note: This article may be obtained online without charge.

Astrobiology, space medicine, space biology,