NASA Spaceline Current Awareness List #1,117 27 September 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Mair DB, Tsui JH, Higashi T, Koenig P, Dong Z, Chen JF, Meir JU, Smith AST, Lee PHU, Ahn EH, Countryman S, Sniadecki NJ, Kim DH.Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform.Proc Natl Acad Sci USA. 2024 Sep 23;121(40):e2404644121.Note: ISS results.
   
   Journal Impact Factor: 9.4
   
   Funding: J.U. Meir is affiliated with NASA Johnson Space Center.
2. Landon LB.Integrated NASA and private astronaut crews readiness needs assessment: Summary report of a NASA-sponsored technical interchange meeting.J Space Saf Eng. 2024 Sep 5. Online ahead of print.Note: From the abstract: “NASA facilitated a Technical Interchange Meeting to assess NASA readiness to host and integrate crews of NASA and private astronauts on the International Space Station. Experts from NASA research, operations, and other government organizations identified research gaps and countermeasure needs to enhance current efforts and protect crew health and safety.”
   
   Journal Impact Factor: 1.0
   
   Funding: “Funding for the Integrated NASA and Private Astronaut Crews Readiness Needs Assessment Technical Interchange Meeting was provided by NASA direct funding to the Behavioral Health & Performance Lab- oratory at Johnson Space Center. LBL was also supported by KBR’s Human Health and Performance Contract NNJ15HK11B through NASA.”
3. Finkelstein SR, Patel R, Deland K, Mercer J, Starr B, Zhu D, Min H, Reinsvold M, Campos LDS, Williams N, Luo L, Ma Y, Neff J, Hoenerhoff M, Moding EJ, Kirsch DG.⁵⁶Fe-ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice.Radiat Res. 2024 Sep 23. Online ahead of print.PI: D.G. KirschJournal Impact Factor: 2.5
   
   Funding: “This work was funded by grants from NASA (NNX11AC60G) and the NCI (2R35 CA197616) to DGK. We thank Adam Rusek and his team at NASA Space Radiation Laboratory and Peter Guida at Brookhaven National Laboratory for their assistance with these experiments.”
4. George SP, Gaza R, Matthiä D, Laramore D, Lehti J, Campbell-Ricketts T, Kroupa M, Stoffle N, Marsalek K, Przybyla B, Abdelmelek M, Aeckerlein J, Bahadori AA, Barzilla J, Dieckmann M, Ecord M, Egeland R, Eronen T, Fry D, Jones BH, Hellweg CE, Houri J, Hirsh R, Hirvonen M, Hovland S, Hussein H, Johnson AS, Kasemann M, Lee K, Leitgab M, McLeod C, Milstein O, Pinsky L, Quinn P, Riihonen E, Rohde M, Rozhdestvenskyy S, Saari J, Schram A, Straube U, Turecek D, Virtanen P, Waterman G, Wheeler S, Whitman K, Wirtz M, Vandewalle M, Zeitlin C, Semones E, Berger T.Space radiation measurements during the Artemis I lunar mission.Nature. 2024 Sep 18.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 50.5
   
   Funding: “The NASA HERA development was financed by the NASA Advanced Exploration Systems RadWorks programme. NASA contractor labour was performed in support of the NASA Human Health and Performance contract NNJ15HK11B. The EAD development by Aboa Space Research Oy (ASRO), Finland and German Aerospace Center (DLR), Germany was financed by the European Space Agency (ESA) contract 4000125486/18/NL/PG/gm. The MARE development was financed by DLR under ‘Forschung unter Weltraumbedingungen’: OrionRad: 2475019 and Strahlenrisiken: 2475075 and by the Israel Space Agency (ISA). StemRad was financed for MARE by the ISA contract 4501432315. …”
5. Yun S, Kiffer FC, Bancroft GL, Guzman CS, Soler I, Haas HA, Shi R, Patel R, Lara-Jiménez J, Kumar PL, Tran FH, Ahn KJ, Rong Y, Luitel K, Shay JW, Eisch AJ.The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: Implications for deep space missions, female crews, and potential antioxidant countermeasures.J Neurochem. 2024 Sep 25. Online ahead of print.PIs: S. Yun, F.C. Kiffer, J.W. Shay, A.J. EischNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 4.2
   
   Funding: “This work was supported by funds to Sanghee Yun (a 2018 PENN McCabe Pilot grant, a 2019 IBRO travel grant, a 2019 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation, a 2020 PENN Undergraduate Research Foundation grant, 2021 NASA HERO grant 80NSSC21K0814 (PI: Yun) and Augmentation award (PI: Haas), a 2022 Foerderer Fund for Excellence Award, two CHOP Junior Faculty Awards (2021, Bhoj; 2023, Van Batavia) and support to her from NIH awards MH076690 (PI: Tamminga), MH107945 (PI: Eisch), and MH129970 (PI: Eisch), Fred Kiffer (Translational Research Institute for Space Health [TRISH] through NASA cooperative agreement NNX16AO69A, Penn Provost/CHOP Postdoctoral Fellowship for Academic Diversity, Perelman School of Medicine’s Department of Radiation Oncology Pilot Grant (PIs: Fan and Eisch), Amelia Eisch (NIH MH129970; NS007413, DA007290, DA023555, DA016765, MH107945; NASA NNX07AP84G, NNX12AB55G, NNX15AE09G) and support to her from NIH NS126279 (PI: Ahrens-Nicklas), and Jerry Shay (NNX16AE08G and NNX15AI21G). Sanghee Yun and Amelia Eisch were also supported by NIH DK135871 (PI: SA Zderic), NIH NS088555 (PI: AM Stowe) and NIH MH117628 (PI: Lambert). Catalina Guzman and Ivan Soler were supported by PennPREP (R25 GM071745, PI: KL Jordan-Sciutto), Harley Haas was supported by the 2021 Penn Undergraduate Research Mentoring Program (PURM), the 2022 Summer Undergraduate Internship Program (SUIP), the 2023 Penn College Alumni Society Board of Managers, Penn President’s Undergraduate Research Grant, and an Augmentation grant (PI: Haas) to a 2021 NASA HERO grant 80NSSC21K0814 (PI: Yun). Riya Patel was supported by the Rutgers University Douglass Science Undergraduate Program for Excellent in Research (SUPER). Jaysen Lara-Jiménez was supported by SUIP. Yuying Rong was supported by the Undergraduate Translational Research Immersion Program sponsored by PENN Institute for Translational Medicine and Therapeutics.”
6. Britten RA, Fesshaye AS, Tidmore A, Tamgue EN, Alvarado-Arriaga PA.Different spectrum of space radiation induced cognitive impairments in radiation-naïve and adapted rats.Life Sci Space Res. 2024 Sep 19. Online ahead of print.PI: R.A. BrittenJournal Impact Factor: 2.9
   
   Funding: “This work was funded by NASA grant support NNX14AE73G.”
7. Kimmich MJ, Sundaramurthy S, Geary MA, Lesanpezeshki L, Yingling CV, Vanapalli SA, Littlefield RS, Pruyne D.FHOD-1 and profilin protect sarcomeres against contraction-induced deformation in C. elegans.Mol Biol Cell. 2024 Sep 11:mbcE24040145. Online ahead of print.Note: From the abstract: “Formin HOmology Domain 2-containing (FHOD) proteins are a subfamily of actin-organizing formins important for striated muscle development in many animals. We showed previously that absence of the sole FHOD protein, FHOD-1, from Caenorhabditis elegans results in thin body wall muscles with misshapen dense bodies that serve as sarcomere Z-lines. We demonstrate here that mutations predicted to specifically disrupt actin polymerization by FHOD-1 similarly disrupt muscle development, and that FHOD-1 cooperates with profilin PFN-3 for dense body morphogenesis, and with profilins PFN-2 and PFN-3 to promote body wall muscle growth.” This article may be obtained online without charge.
8. Hagan ML, Tuladhar A, Yu K, Alhamad DW, Bensreti H, Dorn J, Piedra VM, Cantu N, Stokes EG, Blumenthal D, Roberts RL, Balayan V, Bass SM, Dickerson T, Cartelle AL, Montesinos-Cartagena M, Awad ME, Castro AA, Garland T Jr, Cooley MA, Johnson M, Hamrick MW, McNeil PL, McGee-Lawrence ME.Osteocyte Sptbn1 deficiency alters cell survival and mechanotransduction following formation of plasma membrane disruptions (PMD) from mechanical loading.Calcif Tissue Int. 2024 Sep 14. Online ahead of print.PI: M.E. McGee-LawrenceJournal Impact Factor: 3.3
   
   Funding: “This work was funded by the National Science Foundation (NSF BMMB #1727949 to MM-L; NSF IOS #2038528 to TG), NASA (NASA Space Biology Grant #80NSSC21K0274 to MM-L) and the NIH (S10 OD025177, P01 AG036675 Core B). The authors wish to acknowledge the Augusta University Electron Microscopy and Histology Core for histological specimen preparation and the Augusta University Cell Imaging Core for assistance with imaging-related experiments.”
9. Poignant F, Pariset E, Plante I, Ponomarev AL, Evain T, Viger L, Slaba TC, Blattnig SR, Costes SV.DNA break clustering as a predictor of cell death across various radiation qualities: Influence of cell size, cell asymmetry, and beam orientation.Integr Biol (Camb). 2024 Sep 19;16:zyae015.PI: E. ParisetNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 1.5
   
   Funding: “This work was supported by the Lawrence Berkeley National Laboratory Innovation grant #DE-AC02-05CH11231, NASA grant NNL15AA08I and NASA Human Research Program grant NNJ16HP (PI. Costes); the NASA Langley Cooperative Agreement 80LARC17C0004 and the NASA Langley Research Center contract 80LARC23DA003 (F.P.); the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (E.P.); the Human Research Program under the Space Operations Mission Directorate at NASA (S.B., T.S.); and the NASA Human Health and Performance contract NNJ15HK11B (I.P. and A.P).”
10. Sanders LM, Lopez DK, Wood AE, Scott RT, Gebre SG, Saravia-Butler AM, Costes SV.Celebrating 30 years of access to NASA space life sciences data.Gigascience. 2024 Sep 16;13:giae066.Note: From the abstract: “NASA’s space life sciences research programs established a decades-long legacy of enhancing our ability to safely explore the cosmos. From Skylab and the Space Shuttle Program to the NASA Balloon Program and the International Space Station National Lab, these programs generated priceless data that continue to paint a vibrant picture of life in space. These data are available to the scientific community in various data repositories, including the NASA Ames Life Sciences Data Archive (ALSDA) and NASA GeneLab. Here, we recognize the 30-year anniversary of data access through ALSDA and the 10-year anniversary of GeneLab.” This article may be obtained online without charge.
    
    Journal Impact Factor: Not available for this journal
    
    Funding: “OSDR is funded by the Biological and Physical Sciences (BPS) Space Biology Program within the NASA Science Mission Directorate (SMD) and the NASA Human Research Program (HRP).”
11. Thel MC, Cochran JD, Teruya S, Hayashi O, Xie CR, Srinivasan AR, Chavkin NW, Arai Y, Sano S, Mirabal Santos A, De Los Santos J, Fine D, Sabogal N, Ullah I, Helmke S, Rodriguez C, Prokaeva T, Foster RH, Spencer BH, Izumiya Y, Maurer MS, Walsh K, Ruberg FL.Mosaic loss of the Y chromosome is enriched in patients with wild-type transthyretin cardiac amyloidosis and associated with increased mortality.Circ Heart Fail. 2024 Jun 10;17(8):e011681.PI: K. WalshNote: This article is a research letter.
    
    Journal Impact Factor: 7.8
    
    Funding: “This work was supported by University of Virginia Medical Scientist Training Program grant T32GM007267 to J.D. Cochran; a Grant-in-Aid for Scientific Research C from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (grant 22K08134) to Dr Izumiya; and National Institutes of Health (NIH) grants AG073249, HL142650, and HL152174 and National Aeronautics and Space Administration grant 80NSSC21K0549 to Dr. Walsh.”
12. Hua J, Mankbadi RR.Prediction and control of broadband noise associated with advanced air mobility-A review.Applied Sciences. 2024 Sep 19;14(18):8455.Note: From the introduction: “Advanced air mobility (AAM) encompasses a range of innovative air transportation systems designed to move people and goods in urban and rural areas using new, highly automated, and electric aircraft. AAM includes several types, such as urban air mobility (UAM); small, unmanned aircraft systems (sUAS); and regional air mobility (RAM).” This article is part of Section “Transportation and Future Mobility” (https://www.mdpi.com/journal/applsci/sections/transportation_future_mobility)and may be obtained online without charge.
    
    Journal Impact Factor: 2.5
    
    Funding: “Authors were funded by [NASA Aeronautics Research Mission Directorate (ARMD) University Leadership Initiative (ULI)] grant number [80NSSC21M0057].”

Other papers of interest:

Carshagen U, Vlok N.An air medical approach to in-flight cardiac arrest management.Air Med J. 2024 Sep-Oct;43(5):383-9. Review.Note: From the abstract: “Cardiac arrest during air medical transport is a complex and challenging issue, with unique factors such as limited physical space with restricted access to patients and equipment, small transport teams, limited resources, clinical isolation, effects of altitude, and the need for rapid decision making. The American Heart Association proposed 10 steps to improve outcomes of in-hospital cardiac arrest and serve as the framework for this article. This article aimed to explore these unique challenges and propose a contextual approach that might serve as the basis for improvement projects looking to improve outcomes for affected patients.” This article may be obtained online without charge.

Astrobiology, space biology, microgravity,

Moleti A, Minniti T, Sharma Y, Russo A, Civiero A, Orlando MP, MacGregor R, Lucertini M, D’Amico A, Pennazza G, Santonico M, Zompanti A, Crisafi A, Deffacis M, Sapone R, Mascetti G, Vadrucci M, Valentini G, Castagnolo D, Botti T, Cerini L, Sanjust F, Sisto R.Otoacoustic estimate of astronauts’ intracranial pressure changes during spaceflight.J Assoc Res Otolaryngol. 2024 Sep 13.Note: ISS results. This article may be obtained online without charge.

Iftime A, Tofolean IT, Pintilie V, Călinescu O, Busnatu S, Papacocea IR.Differential functional changes in visual performance during acute exposure to microgravity analogue and their potential links with spaceflight-associated neuro-ocular syndrome.Diagnostics (Basel). 2024 Aug 30;14(17):1918.Note: From the abstract: “Spaceflight-Associated Neuro-Ocular Syndrome (SANS) is a complex pathology threatening the health of astronauts, with incompletely understood causes and no current specific functional diagnostic or screening test. We investigated the use of the differential performance of the visual system (central vs. perimacular visual function) as a candidate marker of SANS-related pathology in a ground-based microgravity analogue. Methods: We used a simple reaction time (SRT) task to visual stimuli, presented in the central and perimacular field of view, as a measure of the overall performance of the visual function, during acute settings (first 10 min) of vertical, bed rest (BR), –6°, and –15° head-down tilt (HDT) presentations in healthy participants (n = 8).” This article is part of Special Issue “Visual Impairment: Diagnosis and Management” (https://www.mdpi.com/journal/diagnostics/special_issues/T2Y2Q54904) and may be obtained online without charge.

Sampige R, Ong J, Waisberg E, Berdahl J, Lee AG.The hypercapnic environment on the International Space Station (ISS): A potential contributing factor to ocular surface symptoms in astronauts.Life Sci Space Res. 2024 Sep 18. Online ahead of print.Note: This is an opinion/position paper.

Springer M.Space rocks: Astronauts may have the guts for Mars travel-but not the kidneys.Sci Am. 2024 Oct 1;331(3):14.Note: This brief article discusses Siew et al. article titled “Cosmic kidney disease: An integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction” (https://doi.org/10.1038/s41467-024-49212-1) that appeared in Current Awareness list #1,105 and may be obtained online without charge.

Bonanno M, Maggio M, Quartarone A, De Nunzio A, Calabrò R.Simulating space walking: A systematic review on anti-gravity technology in neurorehabilitation.J Neuroeng Rehabil. 2024 Sep 13;21:159. Review.Note: This article may be obtained online without charge.

Caddy HT, Fujino M, Vahabli E, Voigt V, Kelsey LJ, Dilley RJ, Carvalho LS, Takahashi S, Green DJ, Doyle BJ.Simulation of murine retinal hemodynamics in response to tail suspension.Comput Biol Med. 2024 Sep 18;182:109148.Note: From the abstract: “The etiology of spaceflight-associated neuro-ocular syndrome (SANS) remains unclear. Recent murine studies indicate there may be a link between the space environment and retinal endothelial dysfunction.”

Kuwabara M, Mitsuhara T, Teranishi M, Okazaki T, Takeda M, Ishii D, Kondo H, Shimizu K, Hosogai M, Hara T, Maeda Y, Kurose T, Kawahara Y, Yuge L, Horie N.Human cranial bone-derived mesenchymal stem cells cultured under simulated microgravity can improve cerebral infarction in rats.Exp Neurol. 2024 Dec;382:114947.

Miranda S, Vermeesen R, Janssen A, Rehnberg E, Etlioglu E, Baatout S, Tabury K, Baselet B.Effects of simulated space conditions on CD4+ T cells: A multi modal analysis.Front Immunol. 2024 Sep 1;15:1443936.Note: A random positioning machine was used in this study. This article may be obtained online without charge.

Yang J, Cui Y, Zhao J, Tang S, Wang A, Wang J, Chen Y, Luo J, Wang G, Yan J, Du J, Wang J.Simulated microgravity-induced dysregulation of cerebrospinal fluid immune homeostasis by disrupting the blood-cerebrospinal fluid barrier.Brain Behav. 2024 Sep 11;14(9):e3648.Note: From the abstract: “The proportions of immune cells in the CSF and peripheral blood (PB) of SMG rats were analyzed using flow cytometry. Immune function was evaluated by measuring cytokine concentrations using the Luminex method. The histomorphology and ultrastructure of the choroid plexus epithelia were determined. The concentrations of intercellular junction proteins in choroid plexus epithelial cells, including vascular endothelial-cadherin (VE-cadherin), zonula occludens 1 (ZO-1), Claudin-1 and occludin, were detected using western blotting and immunofluorescence staining to characterize BCSFB injury.” This article may be obtained online without charge.

Stering JA, Biggs AE, Carney TE, Oest ME, Simone BA.Caloric restriction diet attenuates systemic bone fragility after radiotherapy.Radiat Res. 2024 Sep 23. Online ahead of print.

Keam S, Turner N, Kugeratski FG, Rico R, Colunga-Minutti J, Poojary R, Alekseev S, Patel AB, Li YJ, Sheshadri A, Loghin ME, Woodman K, Aaroe AE, Hamidi S, Iyer PC, Palaskas NL, Wang Y, Nurieva R.Toxicity in the era of immune checkpoint inhibitor therapy.Front Immunol. 2024 Aug 22;15:1447021. Review.Note: This article is part of Research Topic “Biomarkers of Immunotoxicity from Immune Checkpoint Inhibitors” (https://www.frontiersin.org/research-topics/59927/biomarkers-of-immunotoxicity-from-immune-checkpoint-inhibitors/overview) and may be obtained online without charge.

Seong M, Sun K, Kim S, Kwon H, Lee SW, Veerla SC, Kang DK, Kim J, Kondaveeti S, Tawfik SM, Park HW, Jeong HE.Multifunctional magnetic muscles for soft robotics.Nat Commun. 2024 Sep 10;15:7929.Note: From the abstract: “Despite recent advancements, artificial muscles have not yet been able to strike the right balance between exceptional mechanical properties and dexterous actuation abilities that are found in biological systems. Here, we present an artificial magnetic muscle that exhibits multiple remarkable mechanical properties and demonstrates comprehensive actuating performance, surpassing those of biological muscles.” This article may be obtained online without charge.

Mendes Zambetta R, Signini ÉF, Catai AM, Santos T, Michaliski ES, Nazario AK, Ocamoto GN, Frigieri G, Russo TL.Is the ICP pulse waveform P2/P1 ratio during -6° head-down tilt associated with relative VO₂ peak? A non-invasive intracranial compliance monitoring approach.Brain Spine. 2024;4:103327.Note: Head-down tilt study.