NASA Spaceline Current Awareness List #1,115 6 September 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Gonzalez E, Lee MD, Tierney BT, Lipieta N, Flores P, Mishra M, Beckett L, Finkelstein A, Mo A, Walton P, Karouia F, Barker R, Jansen RJ, Green SJ, Weging S, Kelliher J, Singh NK, Bezdan D, Galazska J, Brereton NJB.Spaceflight alters host-gut microbiota interactions.npj Biofilms Microbiomes. 2024 Aug 29;10:71.Note: : ISS results. This article is part of Collection “Space Omics and Medical Atlas (SOMA) across orbits” (https://www.nature.com/immersive/d42859-024-00009-8/index.html). Several articles from this collection have appeared in previous Current Awaress Lists #1,110, #1,106, #1,105, #1,104, #1,100, and #1,074. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
   
   Journal Impact Factor: 7.8
   
   Funding: “This research was generated by the NASA GeneLab Analysis Working Group for Microbes. The team would like to acknowledge the GeneLab for School (GL4S) team for supporting young scientists. NB would like to acknowledge support from the University College Dublin Ad Astra program. Genelab is funded by the Space Biology Program (Science Mission Directorate, Biological and Physical Sciences Division) of the National Aeronautics and Space Administration. Open access was funded by NASA GeneLab.”
2. Letourneau J, Carrion VM, Zeng J, Jiang S, Osborne OW, Holmes ZC, Fox A, Epstein P, Tan CY, Kirtley M, Surana NK, David LA.Interplay between particle size and microbial ecology in the gut microbiome.Isme j. 2024 Aug 30. Online ahead of print.PI: L.A. DavidNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 10.8
   
   Funding: “This work was supported by National Institutes of Health grant 1R01DK116187, Office of Naval Research grant N00014-18-1-2616, Translational Research Institute through Cooperative Agreement NNX16AO69A, the Damon Runyon Cancer Research Foundation, and Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Award.”
3. Suh A, Ditelberg S, Szeto JJ, Kumar D, Ong J, Gibson CR, Mader TH, Waisberg E, Lee AG.Safety protocols, precautions, and countermeasures aboard the International Space Station (ISS) to prevent ocular injury.Surv Ophthalmol. 2024 Sep 3. Review. Online ahead of print.Journal Impact Factor: 5.1
   
   Funding: C.R. Gibson is affiliated with NASA Johnson Space Center.
4. Clément G, Moudy SC, Macaulay TR, Mulder E, Wood SJ.Effects of intermittent seating upright, lower body negative pressure, and exercise on functional tasks performance after head-down tilt bedrest.Front Physiol. 2024 Sep 6;1442239.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.2
   
   Funding: “The National Aeronautics and Space Administration (NASA) provided funding for this study. The data reported here were from the NASA Human Research Program Standard Measures Cross Cutting Project.”
5. Bellisle RF, Peters BT, Oddsson L, Wood SJ, Macaulay TR.A pilot study to evaluate the relationships between supine proprioception assessments and upright functional mobility.Brain Sci. 2024 Jul 30;14(8):768.Note: This article is part of Section “Sensory and Motor Neuroscience” (https://www.mdpi.com/journal/brainsci/sections/Sensory_Motor_Neuroscience_). The Section also includes an article from previous Current Awareness List #1,034 https://doi.org/10.3390/brainsci13020189. This article may be obtained online without charge.
   
   Journal Impact Factor: 2.7
   
   Funding: “This work was supported by the University Space Research Association Internship Program, NASA’s Human Research Program (HRP) Human Health Countermeasures (HHC) Element, and NASA’s Mars Campaign Office (MCO) Crew Health and Performance (CHP) Crew Health Countermeasures (CHC).”
6. Lintao RCV, Richardson LS, Kammala AK, Chapa J, Yunque-Yap DA, Khanipov K, Golovko G, Dalmacio LMM, Menon R.PGRMC2 and HLA-G regulate immune homeostasis in a microphysiological model of human maternal-fetal membrane interface.Commun Biol. 2024 Aug 23;7:1041.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.2
   
   Funding: D.A. Yunque-Yap is affiliated with NASA Johnson Space Center.
7. Sleiman A, Miller KB, Flores D, Kuan J, Altwasser K, Smith BJ, Kozbenko T, Hocking R, Wood SJ, Huff J, Adam-Guillermin C, Hamada N, Yauk C, Wilkins R, Chauhan V.AOP report: Development of an adverse outcome pathway for deposition of energy leading to learning and memory impairment.Environ Mol Mutagen. 2024 Sep 4. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.3 (Clarvate)
   
   Funding: “Solutions Fund; Genomics Research andDevelopment Initiative; Canadian SpaceAgency; NASA Langley Research CenterCooperative Agreement, Grant/AwardNumber: 80LARC17C0004.”
8. Jones I, Vermillion D, Tracy C, Denton R, Davis R, Geszvain K.Isolation, characterization, and genetic manipulation of cold-tolerant, manganese-oxidizing Pseudomonas sp. strains.Appl Environ Microbiol. 2024 Aug 30:e0051024. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.9
   
   Funding: R. Davis is affiliated with NASA Johnson Space Center.
9. Truong DQ, Thomas C, Ira S, Valter Y, Clark TK, Datta A.Unpacking galvanic vestibular stimulation using simulations and relating current flow to reported motions: Comparison across common and specialized electrode placements.PLoS One. 2024 Aug 26;19(8):e0309007.Note: From the abstract: “Galvanic Vestibular Stimulation (GVS) is a non-invasive electrical stimulation technique that is typically used to probe the vestibular system. When using direct current or very low frequency sine, GVS causes postural sway or perception of illusory (virtual) motions. GVS is commonly delivered using two electrodes placed at the mastoids, however, placements involving additional electrodes / locations have been employed. Our objective was to systematically evaluate all known GVS electrode placements, compare induced current flow, and how it relates to the archetypal sway and virtual motions. The ultimate goal is to help users in having a better understanding of the effects of different placements.” This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “1) Initial who received award: AD 2) Grant numbers: W912CG21C0014 and 80NSSC22CA071 3) Full name of funders: U.S. Department of Defense and National Aeronautics and Space Administration 4) URL of funder: https://www.darpa.mil/ and https://www.nasa.gov/.”

Other papers of interest:

1. Hinca J, Dornowski M.Effects of electroencephalogram neurofeedback intervention on blood C-reactive protein levels in astronauts attending 2-week long analog Moon mission.Brain Sci. 2024 Aug 22;14(8):843.Note: This article is part of Special Issue “Unraveling Brain Networks of Neurological Disorders with Advanced Imaging Technology” (https://www.mdpi.com/journal/brainsci/special_issues/3I73ZY2645) and may be obtained online without charge.
2. Banimohamad-Shotorbani B, Azizsoltani A, Khalaj Z, Rafiei-Baharloo M, Ghotaslou A, Fathi-karkan S.Exploring the frontier of space medicine: The nexus of bone regeneration and astronaut health in microgravity conditions.Microgravity Sci Technol. 2024 Sep 2;36(5):51. Review.
3. Garmany A, Yamada S, Park S, Terzic A.Plasma biomarkers of first all-civilian spaceflight to the International Space Station.Mayo Clin Proc. 2024 Sep;99(9):1523-5.Note: This article is a research letter.
4. Xie X, Jaleel A, Zhan J, Ren M.Microalgae: Towards human health from urban areas to space missions.Front Plant Sci. 2024 Aug 15;15:1419157.Note: This article is part of Section “Biotechnological Advances in the Sustainable Exploitation of Coastal Photosynthetic Organisms” (https://www.frontiersin.org/research-topics/63234/biotechnological-advances-in-the-sustainable-exploitation-of-coastal-photosynthetic-organisms/articles) and may be obtained online without charge.
5. Si SY, Qin YY, Wu YY, Ma XY, Shang Y, Song SJ, Guo YC.[Effect of collagen peptides on function of mouse T lymphocytes under simulated microgravity].Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Aug;32(4):1258-63. Chinese.Note: A rotary cell culture system was used in this study.
6. Wang N, Zuo Z, Meng T, Liu Y, Zheng X, Ma Y.Salidroside alleviates simulated microgravity-induced bone loss by activating the Nrf2/HO-1 pathway.J Orthop Surg Res. 2024 Sep 2;19:531.Note: Hindlimb unloading and the rotary cell culture system were used to simulate microgravity. This article may be obtained online without charge.
7. Zong B, Wang J, Wang K, Hao J, Han JY, Jin R, Ge Q.Effects of ginsenoside Rb1 on the crosstalk between intestinal stem cells and microbiota in a simulated weightlessness mouse model.Int J Mol Sci. 2024 Aug 12;25(16):8769.Note: Hindlimb unloading study. This article is part of Section “Molecular Microbiology” (https://www.mdpi.com/journal/ijms/sections/molecular_microbiology) and may be obtained online without charge.
8. Xu L, Zhang L, Li G, Zhang X, Sun Q, Hu Z, Cao X, Wang Y, Shi F, Zhang S.Inhibiting histone deacetylase 6 suppresses the proliferation of microvascular endothelial cells by epigenetically activating miR-375-3p, potentially contributing to bone loss during mechanical unloading.J Transl Med. 2024 Sep 2;22:811.Note: 2D clinostat and hindlimb unloading study. This article is part of Section “Regenerative Medicine” (https://translational-medicine.biomedcentral.com/articles/sections/regenerative-medicine) and may be obtained online without charge.
9. Jin Z, Mao Y, Guo Q, Yin Y, Kiram A, Zhou D, Yang J, Zhou Z, Xue J, Feng Z, Liu Z, Qiu Y, Fu T, Gan Z, Zhu Z.Imbalanced skeletal muscle mitochondrial proteostasis causes bone loss.Research (Wash D C). 2024 Aug 30;7:0465.Note: This article may be obtained online without charge.
10. Deng M-D, Zhang X-J, Feng Q, Wang R, He F, Yang F-W, Liu X-M, Sun F-F, Tao J, Li S, Chen Z.The impact of high-altitude migration on cardiac structure and function: A 1-year prospective study.Front Physiol. 2024 Aug 29;15:1459031.Note: This article may be obtained online without charge.
11. McClure TS, Phillips J, Kernagis D, Coleman K, Chappe E, Cutter GR, Egan B, Norell T, Stubbs BJ, Bamman MM, Koutnik AP.Ketone monoester attenuates oxygen desaturation during weighted ruck exercise under acute hypoxic exposure but does not impact cognitive performance.Exp Physiol. 2024 Aug 27. Online ahead of print.Note: This article may be obtained online without charge.
12. Ren H, Zhu Y-P, Su R, Li H, Pan Y-Y.Hyperbaric intervention ameliorates the negative effects of long-term high-altitude exposure on cognitive control capacity.Front Physiol. 2024 Aug 29;15:1378987.Note: This article may be obtained online without charge.

Astrobiology, space biology, space life science, space medicine, microgravity,