NASA Spaceline Current Awareness List #1,111 2 August 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Brunstetter TJ, Zwart SR, Brandt K, Brown DM, Clemett SJ, Douglas GL, Gibson CR, Laurie SS, Lee AG, Macias BR, Mader TH, Mason SS, Meir JU, Morgan AR, Nelman M, Patel N, Sams C, Suresh R, Tarver W, Tsung A, Van Baalen MG, Smith SM.Severe spaceflight-associated neuro-ocular syndrome in an astronaut with 2 predisposing factors.JAMA Ophthalmol. 2024 Jul 25.Note: ISS results.
   
   Journal Impact Factor: 7.8
   
   Funding: T.J. Brunstetter, G.L. Douglas, B.R. Macias, J.U. Meir, A.R. Morgan, C. Sams, R. Suresh, W. Tarver, M.G. Van Baalen, and S.M. Smith are affiliated with NASA Johnson Space Center.
2. Sharma S, Gilberto VS, Rask J, Chatterjee A, Nagpal P.Inflammasome-inhibiting nanoligomers are neuroprotective against space-induced pathology in healthy and diseased three-dimensional human motor and prefrontal cortex brain organoids.ACS Chem Neurosci. 2024 Jul 31. Online ahead of print.Note: ISS results.
   
   Journal Impact Factor: 4.1
   
   Funding: J. Rask is affiliated with NASA Ames Research Center.
3. Tomilovskaya E, Bekreneva M, Rukavishnikov I, Kofman I, Kitov V, Lysova N, Rosenberg M, Grishin A, Saveko A, Fomina E, Wood SJ, Reschke M.Qualitative analysis of the presence of gaze-evoked nystagmus in astronauts after long term spaceflights. Results of “field test” experiment.Acta Astronaut. 2024 Jul 31. Online ahead of print.Note: ISS results.
   
   Journal Impact Factor: 3.1
   
   Funding: “The work with Russian cosmonauts is supported by the Russian Academy of Sciences (FMFR-2024-0033). The work with astronauts was supported by NASA Human Research Program. …”
4. Velichala SR, Kassel RD, Ly V, Watenpaugh DE, Lee SMC, Macias BR, Hargens AR.Self-generated lower body negative pressure exercise: A low power countermeasure for acute space missions.Life (Basel). 2024 Jun 24;14(7):793.PI: A.R. HargensNote: This article is part of Special Issue “Microgravity and Spaceflight: New Insights and Potential Defense Strategies” (https://www.mdpi.com/journal/life/special_issues/4960LB6E64). The Special Issue also includes articles from previous Current Awareness Lists #1,061 https://doi.org/10.3390/life13071423 and #1,081 https://doi.org/10.3390/life13122332 and https://doi.org/10.3390/life13122245. This article may be obtained online without charge.
   
   Journal Impact Factor: 4.3
   
   Funding: “This research was funded by a grant Self-Generated LBNP for Deep-Space Missions (NASA 80NSSC19K0409).”
5. van Loon J, Berezovska OP, Bervoets TJM, Montufar-Solis D, Semeins CM, Zandieh-Doulabi B, Rodionova PNV, Duke J, Veldhuijzen JP.Growth and mineralization of fetal mouse long bones under microgravity and daily 1 g gravity exposure.npj Microgravity. 2024 Jul 27;10:80.Note: From the abstract: “In a previous Space Shuttle/Spacelab experiment (STS-42), we observed direct responses of isolated fetal mouse long bones to near weightlessness. This paper aimed to verify those results and study the effects of daily 1×g exposure during microgravity on the growth and mineralization of these bones. Two experiments were conducted: one on an American Space Shuttle mission (IML-2 on STS-65) and another on a Russian Bio-Cosmos flight (Bion-10 on Cosmos-2229).” This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This study was supported by the Space Research Organization of the Netherlands (SRON) with grants MG-004 and MG-034, by NASA with grant NCC2-876 and ESA contract 4000136280/21/NL/KML/rk.”
6. Sano S, Walsh K.Can dental problems be indicative of clonal hematopoiesis?Cell Res. 2024 Jul 25.PI: K. WalshNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 28.1
   
   Funding: “AG073249/U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging); AG086508/U.S. Department of Health & Human Services NIH | National Institute on Aging (U.S. National Institute on Aging); 80NSSC21K0549/National Aeronautics and Space Administration (NASA).”
7. Casale CE, Goel N.Genetic markers of individual differences in response to sleep loss.In: Gehrman P, C. Keene A, F. Grant S, editors. Genetics of Sleep and Sleep Disorders. Cham: Springer International Publishing; 2024. p. 393-416.PI: N. GoelFunding: Funding: “This manuscript was supported by the National Aeronautics and Space Administration (NASA) grant NNX14AN49G and grant 80NSSC20K0243 (to N.G.) and the National Institutes of Health grant NIH R01DK117488 (to N.G.).”
8. DuPont M, Arthur E, Shihab Y, Kenny M, Ravichandran S, Parsons-Wingerter P, Vyas R, Murray MC, Predovic M, Lim S, Jacobs N, Ramesh S, Vu A, Sekaran S, Chalam KV, Moorthy RS, Crosson J, Mason J, Grant MB.Use of VESsel GENeration with optical coherence tomography angiography and fluorescein angiography for detection and quantification of vascular changes in mild and moderate diabetic retinopathy.Life (Basel). 2024 Jul 18;14(7):893.Note: This article is part of Special Issue “Retinal Diseases: From Molecular Mechanisms to Therapeutics” (https://www.mdpi.com/journal/life/special_issues/4642F92096). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
   
   Journal Impact Factor: 4.3
   
   Funding: P. Parsons-Wingerter, R. Vyas, M.C. Murray, M. Predovic, S. Lim, N. Jacobs, S. Ramesh, A. Vu, S. Sekaran, are affiliated with NASA Ames Research Center.
9. Siteni S, Barron S, Luitel K, Shay JW.Radioprotective effect of the anti-diabetic drug metformin.PLoS One. 2024 Jul 23;19(7):e0307598.PI: J.W. ShayNote: This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “This work was supported by NASA Grants # NNX16AE08G to JWS and NNX15AI21G to J.W.S and Albert Fornace.”
10. Wahl D, Risen SJ, Osburn SC, Emge T, Sharma S, Gilberto VS, Chatterjee A, Nagpal P, Moreno JA, LaRocca TJ.Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy.J Neuroinflammation. 2024 Jul 27;21:182.Note: This article may be obtained online without charge.
    
    Journal Impact Factor: 9.3
    
    Funding: “This project was supported in part by NIH awards AG078859, AG070562 and AG060302 (T.J.L.) and AG069361 (D.W.), NASA SBIR Awards 80NSSC22CA116, 80NSSC23CA171 and National Academy of Science Health Longevity Catalyst Award (P.N.), and by intramural (startup) funding from Colorado State University (T.J.L.).”

Other papers of interest:

1. Itkin T, Unger K, Barak Y, Yovel A, Stekolshchik L, Ego L, Aydinov Y, Gerchman Y, Sapir A.Exploiting the unique biology of Caenorhabditis elegans to launch neurodegeneration studies in space.Astrobiology. 2024 Jun 22;24(6):579-89.Note: ISS results. From the abstract: “The 21st century is likely to be the first century in which large-scale short- and long-term space missions become common. Accordingly, an ever-increasing body of research is focusing on understanding the effects of current and future space expeditions on human physiology in health and disease. Yet the complex experimental environment, the small number of participants, and the high cost of space missions are among the primary factors that hinder a better understanding of the impact of space missions on human physiology. The goal of our research was to develop a cost-effective, compact, and easy-to-manipulate system to address questions related to human health and disease in space.”
2. Kim S, Ayan B, Shayan M, Rando TA, Huang NF.Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening.Stem Cell Reports. 2024 Jul 6. Online ahead of print.Note: ISS results. This article may be obtained online without charge.
3. Asrar FM, Bolles D, Ngo-Anh TJ.Healthcare can learn from space exploration to champion disability inclusion.Commun Med (Lond). 2024 Jul 25;4(1):147.Note: From the abstract: “People with disabilities, including healthcare professionals, encounter many obstacles. The space sector is taking steps towards promoting equity, diversity, inclusion and accessibility, including developing the world’s first parastronaut program. Here, we propose that healthcare can learn from space in enhancing disability inclusion.” This article may be obtained online without charge.
4. Chen Z, Liu Z, Wu D, Deng Y.Space and neural cell: The impact of space environment on neurological function and their molecular mechanistic insights.Front Cell Neurosci. 2024 Jul 11;18:1454014.Note: This article is the editorial to Research Topic “Space and Neural Cell: The Impact of Space Environment on Neurological Function and Their Molecular Mechanistic Insights” (https://www.frontiersin.org/research-topics/53086/space-and-neural-cell-the-impact-of-space-environment-on-neurological-function-and-their-molecular-mechanistic-insights#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,072 https://doi.org/10.3389/fncel.2023.1275771, #1,081 https://doi.org/10.3389/fncel.2023.1252958, and #1089 https://doi.org/10.3389/fncel.2024.1296205. This article may be obtained online without charge.
5. Beckett LJ, Williams PM, Toh LS, Hessel V, Gerstweiler L, Fisk I, Toronjo-Urquiza L, Chauhan VM.Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism.npj Microgravity. 2024 Jul 26;10:79. Review.Note: This article may be obtained online without charge.
6. Perez-Poch A, Ballester M, Tresanchez M, Torner J, González DV, Alpiste F, Brigos M, Sánchez E, Martínez G, García S, Polyzos NP, Boada M.Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight.Acta Astronaut. 2024 Oct;223:640-8.Note: From the materials and methods section of the article: “The experiment described herein was performed with a Mudry CAP10B light aircraft during a parabolic flight campaign providing up to 8.5 s of microgravity per parabola. The transportable incubator (37 °C) with the study group samples was lightly attached to the vacant seat of the aircraft so that it could not impede other areas of the cockpit or interfere with the piloting of the aircraft. The flight operations were conducted by the Barcelona-Sabadell Aviation Club; with the pilot-in-command being an experienced aerobatic pilot with more than 1000 flight-hours and extensive experience in this particular type of maneuver.”
7. Down JD, Cornwall-Brady MR, Huang W, Hurwitz M, Floyd SR, Yilmaz OH.Selecting the most relevant mouse strains for evaluating radiation-induced multiple tissue injury after leg-shielded partial-body gamma irradiation.Radiat Res. 2024 Jul 27. Online ahead of print.Note: This article may be obtained online without charge.
8. Neamah HA, Tandio J.Towards the development of foods 3D printer: Trends and technologies for foods printing.Heliyon. 2024 Jul 15;10(13):e33882.Note: This article may be obtained online without charge.
9. Horeau M, Delalande M, Ropert M, Leroyer P, Martin B, Orfila L, Loréal O, Derbré F.Sex similarities and divergences in systemic and muscle iron metabolism adaptations to extreme physical inactivity in rats.J Cachexia Sarcopenia Muscle. 2024 Jul 24. Online ahead of print.Note: This article may be obtained online without charge.
10. Poon CC, Au-Yeung C, Wong KY, Chan Z, Zhou LP, Li G, Wang Y, Zhang Y, Wong MS.Icariin promotes cell adhesion for osteogenesis in bone marrow stromal cells via binding to integrin α5β1.Phytomedicine. 2024 Oct;133:155887.Note: From the abstract: “Icariin, an 8-prenylated flavonoid glycoside, is an anabolic agent that could exert rapid estrogenic actions via ligand-independent activation of estrogen receptor alpha (ERα) in osteoblastic cells to promote osteogenesis. However, relatively little is known about its direct cellular target, its protective effects, and cell adhesion activities in bone marrow stromal cells (BMSCs) against microgravity. In the present study, the effects of icariin on osteogenesis and cell adhesion under microgravity were examined with the involvement of integrin receptor α5β1, connexin 43, and CAMs.”
11. Yan W, Hu W, Song Y, Liu X, Zhou Z, Li W, Cao Z, Pei W, Zhou G, Hu G.Differential network analysis reveals the key role of the ECM-receptor pathway in α-particle-induced malignant transformation.Mol Ther Nucleic Acids. 2024 Sep 10;35(3):102260.Note: This article may be obtained online without charge.