NASA Spaceline Current Awareness List #1,110 26 July 2024 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. 
   Morris PD, Anderton RA, Marshall-Goebel K, Britton JK, Lee SMC, Smith NP, van de Vosse FN, Ong KM, Newman TA, Taylor DJ, Chico T, Gunn JP, Narracott AJ, Hose DR, Halliday I.Computational modeling of cardiovascular pathophysiology to risk stratify commercial spaceflight.Nat Rev Cardiol. 2024 Jul 19. Review.Journal Impact Factor: 41.7
   
   Funding: K. Marshall-Goebel and S.M.C. Lee are affiliated with NASA Johnson Space Center.
2. Ong J, Soares B, Osteicoechea D, Kadipasaoglu CM, Waisberg E, Suh A, Sampige R, Nguyen T, Masalkhi M, Sarker P, Zaman N, Tavakkoli A, Berdahl J, Chévez-Barrios P, Lee AG.The cornea during spaceflight: A frontier in space medicine ophthalmology.Eye (Lond). 2024 Jul 21.PI: J. Berdahl/NSBRI, A. Tavakkoli Note: This article is a comment. PIs would like to note that goggles now known as FYSX Ocular Pressure Adjusting Pump have recently been approved by the FDA and were originally funded by NASA/NSBRI.
   
   Journal Impact Factor: 2.8
   
   Funding: PIs report funding from NASA/NSBRI “Equinox Balance Goggles: The Effects of Local Orbital Pressure Changes on Intraocular Pressure” and NASA HRP for vision assessment in space.
3. Rutter LA, MacKay MJ, Cope H, Szewczyk NJ, Kim J, Overbey E, Tierney BT, Muratani M, Lamm B, Bezdan D, Paul AM, Schmidt MA, Church GM, Giacomello S, Mason CE.Protective alleles and precision healthcare in crewed spaceflight.Nat Commun. 2024 Jul 22;15:6158.PI: C.E. MasonNote: This article is a perspective and part of Collection “Space Omics and Medical Atlas (SOMA) across orbits” (https://www.nature.com/immersive/d42859-024-00009-8/index.html). This article may be obtained online without charge.
   
   Journal Impact Factor: 14.7
   
   Funding: “LAR and MM are supported by the Japan Society for the Promotion of Science (JSPS) funding JP15H05940 and JP20H03234. LAR is supported by the JSPS postdoctoral fellowship P20382. European (HC, NJS, and SG) contribution is supported by the ESA Topical Team ‘Space Omics: Towards an integrated ESA/NASA-omics database for spaceflight and ground facilities experiments’ grant 4000131202/20/NL/PG/pt. SG is supported by Formas grant 2017-01066_3. HC is supported by the Horizon Centre for Doctoral Training at the University of Nottingham (UKRI Grant No. EP/S023305/1). NJS is supported by NASA (NSSC22K0250, NSSC22K0278). CEM thanks the WorldQuant Foundation, NASA (NNX14AH50G, NNX17AB26G, 80NSSC23K0832, 80NSSC22K0254, NNH18ZTT001N-FG2), the National Institutes of Health (R01MH117406, P01CA214274, R01AI151059, R01CA249054, 7029-23), and the LLS (MCL7001-18, LLS 9238-16).”
4. Wadhwa A, Moreno-Villanueva M, Crucian B, Wu H.Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks.Immun Ageing. 2024 Jul 20;21(1):50. Review.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.2
   
   Funding: “Funding provided by the National Aeronautics and Space Administration, University Space Research Association, and the National Institutes of Health.”
5. Reddy K, Kunda D, Gilbertson RL, McDonald KA, Nandi S, Sudarshana MR.First complete genome sequence resource of a Lettuce mosaic virus isolate from the United States of America.PhytoFrontiers™. 2024 Jul 21. Online ahead of print.PI: K.A. McDonaldNote: This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal.
   
   Funding: “This work was supported by a grant from the Translational Research Institute for Space Health (TRISH) through NASA (grant number NNX16AO69A) KAM to KM, SN, and MRS, and partly supported by USDA-ARS CRIS project number 2032-22000-016-00D.”

Other papers of interest:

1. Braun JL, Fajardo VA.Spaceflight increases sarcoplasmic reticulum Ca²⁺ leak and this cannot be counteracted with BuOE treatment.npj Microgravity. 2024 Jul 19;10:78.Note: ISS results. This article is a brief communication and may be obtained online without charge.
2. He X, Zhao L, Huang B, Zhang G, Lu Y, Mi D, Sun Y.Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegans.Life Sci Space Res. 2024 Aug;42:117-32.Note: ISS results.
3. Kassels A, Arora JS, Sharma SN, Sharma AN.A systematic review of the effects of space and simulated microgravity on dermatologic conditions.JAAD Reviews. 2024 Sep;1:4-6. Review.Note: This article may be obtained online without charge.
4. Mendes Zambetta R, Signini ÉDF, Ocamoto GN, Catai AM, Uliam NR, Santarnecchi E, Russo TL.Effects of weightlessness on the cardiovascular system: A systematic review and meta-analysis.Front Physiol. 2024 Jul 25;15:1438089. Review.Note: This article may be obtained online without charge.
5. Rasheed M, Tahir A, Maazouzi M, Wang H, Li Y, Chen Z, Deng Y.Interplay of miRNAs and molecular pathways in spaceflight-induced depression: Insights from a rat model using simulated complex space environment.Faseb j. 2024 Jul 31;38(14):e23831.
6. Binneboessel S, Gerdes N, Baertschi M, Kaya S, Geerling G, Kelm M, Jung C.Changes in ocular perfusion and pressure changes in gravitational alteration contribute to spaceflight-associated neuro-ocular syndrome.Arterioscler Thromb Vasc Biol. 2024 May 9;44(7):1716-8.
7. Diaz TE, Ives EC, Lazare DI, Buckland DM.Expiration analysis of the International Space Station formulary for exploration mission planning.npj Microgravity. 2024 Jul 23;10:76.Note: This article may be obtained online without charge.
8. Mueller A, Petersen E, Carroll D, Lim RB, Wisbach GG.Space surgery: A SAGES’ white paper.Surg Endosc. 2024 Jul 22.Note: From the abstract: “Space travel is experiencing a renaissance with expanding commercial and international efforts. Space surgery will have growing relevance as mission frequency and distances increase beyond low-Earth orbit.”
9. Sasaki S.Observation of possible mold spore attachment, germination and growth on the surface of silica aerogel designed for astrobiology mission.Biological Sciences in Space. 2024 Jul 23;38:27-32.Note: This article may be obtained online without charge.
10. Michel JM, Hettinger Z, Ambrosio F, Egan B, Roberts MD, Ferrando AA, Graham ZA, Bamman MM.Mitigating skeletal muscle wasting in unloading and augmenting subsequent recovery.J Physiol. 2024 Jul 19. Review. Online ahead of print.
11. Pontiggia A, Gomez-Merino D, Quiquempoix M, Beauchamps V, Boffet A, Fabries P, Chennaoui M, Sauvet F.MATB for assessing different mental workload levelsFront Physiol. 2024 Jul 23;15:1408242. Review.Note: From the abstract: “Multi-Attribute Task Battery (MATB) is a computerized flight simulator for aviation-related tasks, suitable for non-pilots and available in many versions, including open source. MATB requires the individual or simultaneous execution of 4 sub-tasks: system monitoring (SYSMON), tracking (TRACK), communications (COMM), and resource management (RESMAN). Fully customizable, the design of test duration, number of sub-tasks used, event rates, response times and overlap, create different levels of mental load. MATB can be combined with an additional auditory attention (Oddball) task, or with physiological constraints (i.e., sleep loss, exercise, hypoxia). We aimed to assess the main characteristics of MATB design for assessing the response to different workload levels.” This article may be obtained online without charge.
12. Wani A, Prabhakar B, Shende P.Strategic aspects of space medicine: A journey from conventional to futuristic requisites.Space Sci Technol. 2024 Jun 24;4:0123.
13. Zhu X, Maier G, Panda S.Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care.Trends in Cancer. 2024;10(3):196-207.Note: This article may be obtained online without charge.
14. Grace M.Aviation podiatry – What place does podiatry have in aerospace medicine?International Journal of Occupational Safety and Health. 2024 Jul 1;14(3).Note: This article may be obtained online without charge.
15. Aggarwal J.Space policy imperative: The urgency for a new international space governance system.Astropolitics. 2024 Jul 18;1-12. Online ahead of print.Note: This is a viewpoint essay.

Astrobiology, space biology, microgravity,