NASA Spaceline Current Awareness List #1,154 20 June 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Huang AS, Jalili J, Walker E, Weinreb RN, Laurie SS, Macias BR, Christopher M.Artificial intelligence deep learning models to predict spaceflight associated neuro-ocular syndrome (SANS).Am J Ophthalmol. 2025 Jun 10. Online ahead of print.PI: A.S. HuangNote: From the abstract: “AI deep learning models were trained to predict SANS onset by using two OCT datasets: pre- and inflight OCT images acquired from astronauts (flight data) and pre- and in-bedrest images from research participants undergoing head-down tilt bedrest (HDTBR) as an Earth-bound model of SANS (ground data). Both datasets were partitioned by participant into training and testing data. Resnet50-based models were trained using exclusively flight data, exclusively ground data, and a combination of both. All models were evaluated based on their ability to predict SANS using only preflight or pre-bedrest imaging in both datasets. Performance was assessed using receiver operating characteristic (ROC) areas under the curve (AUC). Class activation maps (CAMs) were generated to identify impactful image regions.”
   
   Journal Impact Factor: 4.1
   
   Funding: “Funding for this work came from NASA (80NSSC20K1034 [AH], NNJ15KK11B [BM], NASA HRP Directed Research [BM], NNJ11ZSA002NA [SSL]) and NIH/NEI (R00EY030942 [MC]; P30EY022589 [UCSD]).”
2. Menon A, Mampre D, Isaacman J, Poteet S, Gillis S, Mateus J, Rosenberg M.Cardiopulmonary resuscitation techniques on the Dragon spacecraft: A Polaris Dawn mission study.Wilderness Environ Med. 2025 Jun 11;10806032251346746. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 1.4
   
   Funding: “This work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A.”
3. Geimer S, Niemczak CE, Howard PT, Basner M, Buckey JC.The psychomotor vigilance task for assessing the effects of motion sickness and its treatment.Front Space Technol. 2025 Jun 13;6:1591817.Note: This article is part of Research Topic “Innovation in Medical Space Technology” (https://www.frontiersin.org/research-topics/57838/innovation-in-medical-space-technology/overview). The Research Topic also includes articles from previous Current Awareness Lists #1,108 https://doi.org/10.3389/frspt.2024.1391200; #1,119 https://doi.org/10.3389/frspt.2024.1384457 and https://doi.org/10.3389/frspt.2024.1422868; #1,120 https://doi.org/10.3389/frspt.2024.1456614 and https://doi.org/10.3389/frspt.2024.1457487; and #1,143 https://doi.org/10.3389/frspt.2025.1391331. This article may be obtained online without charge.
   
   Journal Impact Factor: 1.3
   
   Funding: “The author(s) declare that financial support was received for the research and/or publication of this article. Office of Naval Research (ONR) Grant N00014-00-1-0694 and the National Space Biomedical Research Institute Grant NA00404 supported this work.”
4. Costa-Martini JH, Adams EE, Johnston CW.Chemotype- and target-driven genome mining for a new natural product inhibitor of bacterial peptide deformylase.J Am Chem Soc. 2025 Jun 10. Online ahead of print.Note: From the abstract: “Antibiotics are essential for modern medicine, but their use drives the evolution of antimicrobial resistance (AMR) that limits the long-term efficacy of any one drug. To keep pace with AMR and preserve our ability to treat bacterial infections, it is essential that we identify antibiotics with new structures and targets that are not affected by clinical resistance.”
   
   Journal Impact Factor: 15.6 (2 year)
   
   Funding: “This work was supported by seed funds from the Baylor College of Medicine, by an R21 grant from the National Institute of General Medical Sciences (NIGMS; 1R21GM154190), by the Translational Research Institute for Space Health through NASA (NNX16AO69A), and by a recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT; RR210066). C.W.J. is a CPRIT Scholar in Cancer Research.”
5. Opdensteinen P, Caparco AA, Steinmetz NF.Protein-based spherical nanoparticles for dsRNA delivery to nematodes-A platform technology for RNA silencing.Materials Today. 2025 Jun 11. Online ahead of print.PI: P. OpdensteinenNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 21.1
   
   Funding: “This work was supported by USDA grant NIFA-2020-67021-31255 awarded to NFS. P.O. was supported in part through a TRISH postdoctoral fellowship by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A. A.A.C. was supported in part through a USDA post-doctoral fellowship 2022-67012-36698. This work was also supported in part by the National Science Foundation through the University of California San Diego Materials Research Science and Engineering Center (UCSD MRSEC), grant number DMR-2011924.”

Other papers of interest:

1. Cimini G, Gatti M, Bernardini D, Bemporad A, Audas C, Dussap C-G.Towards supervisory model predictive control for circular life support systems in long-term space missions.Life Sci Space Res. 2025 Jun 18. Online ahead of print.Note: From the abstract: “Regenerative Life Support Systems (LSS) fulfill the essential functions for human survival in space, such as atmosphere revitalization, water recovery, food production, and waste management, and are crucial for long-term space missions where the resupply of resources from Earth is not feasible or reliable. Operating a regenerative LSS poses several challenges, mainly related to its complexity, efficiency, and reliability. A set of heterogeneous subsystems involving mechanical, chemical, biological, and energetic processes has to be optimally coordinated in order to meet the requirements on mass, power, crew time, safety, reliability, sustainability and efficiency. In this paper, we address these challenges by proposing a supervisory control layer based on a nonlinear and time-varying Model Predictive Control (MPC) approach.”
2. Moses J, Arzt M, Escopete S, Mozneb M, Wiegand L, Sharma A.Regenerative medicine approaches to address cardiovascular issues during spaceflight.Curr Treat Options Cardiovasc Med. 2025 Jun 16;27:37. Review.
3. Pasha S, Ong J, Guo Y, Lee R, Waisberg E, Lee AG, Sarker P, Tavakkoli A.Approaching ocular risks during spaceflight with 3D printing: Technical strategies to protect astronaut vision.Life Sci Space Res. 2025 Jun 13. Review. Online ahead of print.
4. Bashir M, Murtada A, Jubouri M, Bashir A, Williams I, Bailey D.Surgery in space: The ultimate frontier.Exp Physiol. 2025 Jun 10. Online ahead of print.Note: This article is an Editorial.
5. Du X, Zhang Y, Yang Q, Zhang M, Sun Y.Transcriptional changes at different developmental stages of rice (Oryza sativa L.) following lunar orbit flight.Life Sci Space Res. 2025 Jun 19. Online ahead of print.Note: From the abstract: “Plants are regarded as a core component of the life support system for crewed space missions, particularly in deep-space endeavors such as lunar and Martian missions. Therefore, understanding the responses of plants to deep-spaceflight is considered essential. Japonica rice dry seeds (Oryza sativa L.) were carried aboard the Chang’e 5 spacecraft on a flight to the lunar orbit for 23 days. Following their return to Earth, these seeds were planted and cultivated until the tillering and heading stages.”
6. Bonnard T, Doat E, Cazalets JR, Guehl D, Guillaud E.Visual and vestibular reweighting after cyber- and space-sickness.Exp Physiol. 2025 Jun 10. Online ahead of print.Note: This article may be obtained online without charge.
7. Fehrler S, Hornuf L, Vrankar D.What do citizens expect from space?Acta Astronaut. 2025 Jun 16. Online ahead of print.Note: From the abstract: “Bold ventures by billionaires, governmental lunar missions fueled by a new space race, and initial public offerings by space companies have rapidly increased public attention to the space sector. As a result, more and more citizens are forming opinions about space-related topics. These opinions are highly valued by players in this sector, as space missions critically depend on citizens as qualified employees, investors, and supporters of public funding for space endeavors. To provide reliable data about public opinion on space, we surveyed 2,139 citizens in nine developed and emerging space nations with the most significant space budgets in 2023.”
8. MacCarthy C, Koudan E, Shevtsov M, Parfenov V, Petrov S, Levin A, Senatov F, Sykilinda N, Ostrovskiy S, Pekov S, Gushchin I, Popov I, Zinovev E, Bogorodskiy A, Mishin A, Ivanovich V, Rogachev A, Khesuani Y, Borshchevskiy V.Exploring the potential of a bioassembler for protein crystallization in space.npj Microgravity. 2025 Jun 14;11:25.Note: This article may be obtained online without charge.
9. Patel M, Patel P, Munshi NS, Patel S, Patil S, Srivastva A, Dhanraj J, Duggineni R, Mehta P.Microbial contamination and pharmaceutical stability in space environment: Addressing dual challenge with innovative technologies and sustainable practices.Front Space Technol. 2025 Apr 30;6:1553854. Review.Note: This article may be obtained online without charge.
10. Zong H, Fei Y, Liu N.Circadian disruption and sleep disorders in astronauts: A review of multi-disciplinary interventions for long-duration space missions.Int J Mol Sci. 2025 May 28;26(11):5179. Review.Note: This article is part of Special Issue “The Importance of Molecular Circadian Rhythms in Health and Disease” (https://www.mdpi.com/journal/ijms/special_issues/8T8EVJOLAB) and may be obtained online without charge.
11. Agarwal T, Onesto V, Banerjee D, Guo S, Polini A, Vogt CD, Viswanath A, Esworthy T, Cui H, O’Donnell A, Vajanthri KY, Moroni L, Ozbolat IT, Panoskaltsis-Mortari A, Zhang LG, Costantini M, Maiti TK.3D bioprinting in tissue engineering: Current state-of-the-art and challenges towards system standardization and clinical translation.Biofabrication. 2025 Jun 13. Online ahead of print.
12. Estlack Z, Pack A, Golozar M, Butterworth AL, Mathies RA, Kim J.Microfabricated onsite analyzer for biomarkers (MOAB) for automated crew health monitoring.ACS Sens. 2025 Jun 11. Online ahead of print.Note: From the abstract: “Crewed missions to the Moon, Mars, and beyond necessitate advanced health monitoring techniques due to risks such as musculoskeletal degradation, cancer, and kidney issues from prolonged exposure to radiation and microgravity. This paper presents the Microfabricated Onsite Analyzer for Biomarkers (MOAB), a state-of-the-art device designed for extraterrestrial missions capable of precise biomarker detection.”
13. Kotian V, Pool DM, Happee R.Personalizing motion sickness models: Estimation and statistical modeling of individual-specific parameters.Front Syst Neurosci. 2025 Jun 16; 19:1531795.Note: This article may be obtained online without charge.
14. Liao B, Yao Z, Feng J, Liu H.Wheat rhizospheric microbial network’s consistent modular pattern in improved lunar soil simulant accompanied with fungal withdrawal.Acta Astronaut. 2025 Jun 16. Online ahead of print.Note: From the abstract: “Crewed base is the undoubted trend of lunar exploration. Human long-term residence needs Bioregenerative Life Support System (BLSS) where plant cultivation serves as the core functional unit. Given the difficulty of Earth-Moon transport, lunar soil has the potential as plant cultivation substrates in situ, yet its cultivability needs to be improved to meet the life-support needs. Imitating the Earth soil’s bioweathering process, we fermented lunar soil simulant with BLSS’s daily product-the solid waste (fermented from highly lignocellulosic organic waste) as an improvement, and conducted wheat whole-life-span (‘from seed to seed’) cultivation experiment.”
15. Sun Z, Xie S, Hu S, Jiang C, Ding S, Wu L, Xu W, Li H.The impact of lighting conditions on users’ alertness and working memory in confined spaces.Psych J. 2025 Jun 10. Online ahead of print.Note: This article may be obtained online without charge.
16. Zhang Y, Bao Z, Smoljan A, Liu Y, Wang H, Friml J.Foraging for water by MIZ1-mediated antagonism between root gravitropism and hydrotropism.Proc Natl Acad Sci USA. 2025 May 15;122(20):e2427315122. Online ahead of print.Note: This article may be obtained online without charge.

Astrobiology, space biology, space life science, space medicine, Microgravity, ISS,