SPACELINE Current Awareness List

NASA Spaceline Current Awareness List #1,101 24 May 2024 (Space Life Science Research Results)

By Keith Cowing
Status Report
May 29, 2024
Filed under , , , , , ,
NASA Spaceline Current Awareness List #1,101 24 May 2024 (Space Life Science Research Results)
Biofilms are thin, slimy films of bacteria that adhere to surfaces. NASA sent a study to the International Space Station on @SpaceX #CRS29 to find out how these biofilms behave in space. — NASA

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

  1. Adkins AM, Luyo ZNM, Gibbs AJ, Boden AF, Heerbrandt RS, Gotthold JD, Britten RA, Wellman LL, Sanford LD.Alterations in bloodndash;brain barrier integrity and lateral ventricle differ in rats exposed to space radiation and social isolation.Life. 2024 May 16;14(5):636.PI: R.A. Britten, L.D. SanfordNote: This article is part of Special Issue “Feature Paper in Physiology and Pathology” ( and may be obtained online without charge.

    Journal Impact Factor: 3.2

    Funding: “This work was supported by the NASA CBS VNSCOR grant 80NSSC19K1582 and the NASA research grant NNX16AC40G.”
  2. Sandoval SO, Cappuccio G, Kruth K, Osenberg S, Khalil SM, Méndez-Albelo NM, Padmanabhan K, Wang D, Niciu MJ, Bhattacharyya A, Stein JL, Sousa AMM, Waxman EA, Buttermore ED, Whye D, Sirois CL, Williams A, Maletic-Savatic M, Zhao X.Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.Stem Cell Rep. 2024 May 10:S2213-6711(24)00114-0. Review. Online ahead of print.PI: M. Maletic-SavaticNote: This article may be obtained online without charge.

    Journal Impact Factor: 5.9

    Funding: “…Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A grant RAD01013 and NASA grant 21-3DTMPS 2- 0020 (M.M.-S.)…”
  3. Strakowski J, Zhang H, Reschke M, Chiou-Tan FY.Special anatomy series. Imaging inner ear structures with high-frequency ultrasound: Application to physical rehabilitation space medicine.J Int Soc Phys Rehabil Med. 2024 May;7(1):33-8.Note: This article may be obtained online without charge.

    Journal Impact Factor: Not available for this publication

    Funding: M. Reschke is affiliated with NASA Johnson Space Center.
  4. Deo KA, Murali A, Tronolone JJ, Mandrona C, Lee HP, Rajput S, Hargett S, Selahi A, Sun Y, Alge D, Jain A, Gaharwar AK.Granular biphasic colloidal hydrogels for 3D bioprinting.Adv Healthc Mater. 2024 May 15:e2303810. Online ahead of print.PI: A. JainNote: From the abstract: “Granular hydrogels composed of hydrogel microparticles are promising candidates for 3D bioprinting due to their ability to protect encapsulated cells. However, to achieve high print fidelity, hydrogel microparticles need to jam to exhibit shear-thinning characteristics, which is crucial for 3D printing. Unfortunately, this overpacking can significantly impact cell viability, thereby negating the primary advantage of using hydrogel microparticles to shield cells from shear forces. To overcome this challenge, we introduce a novel solution: a biphasic, granular colloidal bioink designed to optimize cell viability and printing fidelity. The biphasic ink consists of cell-laden polyethylene glycol (PEG) hydrogel microparticles embedded in a continuous gelatin methacryloyl (GelMA)-nanosilicate colloidal network. Here, we demonstrate that this biphasic bioink offers outstanding rheological properties, print fidelity, and structural stability. Furthermore, we demonstrate its utility for engineering complex tissues with multiple cell types and heterogeneous microenvironments, which we demonstrate by incorporating β-islet cells into the PEG microparticles and endothelial cells in the GelMA-nanosilicate colloidal network.” This article may be obtained online without charge.

    Journal Impact Factor: 10

    Funding: “…This material is partially based upon work supported by the NASA, BARDA, NIH, and USFDA, under Contract No. 80ARC023CA002; NHLBI of NIH under Award Number R01HL157790, NSF CAREER Award number 1944322, and Texas A&M University President’s Excellence in Research Award (X-Grant) to A.J., and by an American Heart Association Predoctoral Fellowship under Grant No. 906239, and a National Science Foundation Graduate Research Fellowship under Grant No. 1650114 to J.J.T. …”
  5. Waisberg E, Ong J, Kamran SA, Masalkhi M, Paladugu P, Zaman N, Lee AG, Tavakkoli A.Generative artificial intelligence in ophthalmology.Surv Ophthalmol. 2024 May 16:S0039-6257(24)00044-4. Review. Online ahead of print.PI: A. TavakkoliNote: This article may be obtained online without charge.

    Journal Impact Factor: 5.1

    Funding: “NASA Grant [80NSSC20K183]: A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”

Other papers of interest:

  1. Nguyen T, Ong J, Waisberg E, Lee AG.Sleep and optic disc edema in spaceflight associated neuro-ocular syndrome (SANS).Eye (Lond). 2024 May 23.Note: This article is a comment.
  2. Rezaei S, Seyedmirzaei H, Gharepapagh E, Mohagheghfard F, Hasankhani Z, Karbasi M, Delavari S, Aarabi MH.Effect of spaceflight experience on human brain structure, microstructure, and function: Systematic review of neuroimaging studies.Brain Imaging Behav. 2024 May 22. Review.
  3. Rock CG, Kwak ST, Luo A, Yang X, Yun K, Chang Y-H.Realizing the gravity of the simulation: Adaptation to simulated hypogravity leads to altered predictive control.Front Physiol. 2024 May 24;15:1397016.Note: From the abstract: “Accurate predictive abilities are important for a wide variety of animal behaviors. Inherent to many of these predictions is an understanding of the physics that underlie the behavior. Humans are specifically attuned to the physics on Earth but can learn to move in other environments (e.g., the surface of the Moon). However, the adjustments made to their physics-based predictions in the face of altered gravity are not fully understood. The current study aimed to characterize the locomotor adaptation to a novel paradigm for simulated reduced gravity. We hypothesized that exposure to simulated hypogravity would result in updated predictions of gravity-based movement.” This article may be obtained online without charge.
  4. Riego ML, Meher PK, Brzozowska B, Akuwudike P, Bucher M, Oestreicher U, Lundholm L, Wojcik A.Chromosomal damage, gene expression and alternative transcription in human lymphocytes exposed to mixed ionizing radiation as encountered in space.Sci Rep. 2024 May 20;14(1):11502Note: This article may be obtained online without charge.
  5. Mao W, Huai Y, An L, Wang X, Ru K, Patil S, Zhang W, Ran F, Chen Z, Qian A.Microgravity inhibits cell proliferation and promotes senescence and apoptosis in embryonic stem cells.Space: Science & Technology. 2024 Apr 9;4:0104.Note: From the abstract: “With advancements in deep space exploration missions, long-term spaceflights pose potential hazards to the reproductive and developmental functions of astronauts. Embryonic stem cells (ESCs), which are crucial to the development and growth of individual organisms, are observably altered by a microgravity environment. However, the role and mechanisms of microgravity in other activities of ESCs are still unclear. Here, mouse embryonic stem cells (mESCs) were used to investigate and understand the effect of microgravity on their activities. Combined with the SJ-10 satellite and random position machine, which were utilized for spaceflight and microgravity simulation, respectively, the bioinformatic tools were also used to assess the effect that microgravity might have on mESC activities.” This article may be obtained online without charge.
  6. Lotfy M, Khattab A, Shata M, Alhasbani A, Almesmari A, Alsaeedi S, Alyassi S, Kundu B.Destructive effects of UVC radiation on Drosophila melanogaster: Mortality, fertility, mutations, and molecular mechanisms.PLoS One. 2024 May 22;19(5):e0303115.Note: This article may be obtained online without charge.
  7. Szalanczy AM, Sherrill C, Fanning KM, Hart B, Caudell D, Davis AM, Whitfield J, Kavanagh K.A novel TGFβ receptor inhibitor, IPW-5371, prevents diet-induced hepatic steatosis and insulin resistance in irradiated mice.Radiat Res. 2024 May 22. Online ahead of print.
  8. Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T.Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats.Physiol Rep. 2024 Mar 7;12(5):e15969.Note: This article may be obtained online without charge.
  9. Zablotska LB, Little MP, Hamada N.Revisiting an inverse dose-fractionation effect of ionizing radiation exposure for ischemic heart disease: Insights from recent studies.Radiat Res. 2024 May 22. Online ahead of print.
  10. Eazer J, Barsoum M, Smith C, Hotta K, Behnke B, Holmes C, Caldwell J, Ghosh P, Reid-Foley E, Park H, Delp M, Muller-Delp J.Adaptations of bone and bone vasculature to muscular stretch training.JBMR Plus. 2024 Mar;8(3):ziad019.Note: This article may be obtained online without charge.
  11. Gao L, Chen R, Lin X, Liu J, Liu J, Tan Y, Zhang C, Zhang X.Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads.J Bone Miner Metab. 2024 May 16.
  12. Dayarian N, Khadem A.A hybrid boundary element-finite element approach for solving the EEG forward problem in brain modeling.Front Syst Neurosci. 2024 May 3;18:1327674.Note: This article is part of Research Topic “Multimodal Approaches to Investigating Neural Dynamics in Cognition and Related Clinical Conditions: Integrating EEG, MEG, and fMRI Data” ( and may be obtained online without charge.
  13. Abedini A, Sohrabvandi S, Sadighara P, Hosseini H, Farhoodi M, Assadpour E, Alizadeh Sani M, Zhang F, Seyyedi-Mansour S, Jafari SM.Personalized nutrition with 3D-printed foods: A systematic review on the impact of different additives.Adv Colloid Interface Sci. 2024 Jun;328:103181. Review.Note: From the abstract: “Three-dimensional (3D) printing is one of the world’s top novel technologies in the food industry due to the production of food in different conditions and places (restaurants, homes, catering, schools, for dysphagia patients, and astronauts’ food) and the production of personalized food. Nowadays, 3D printers are used in the main food industries, including meat, dairy, cereals, fruits, and vegetables, and have been able to produce successfully on a small scale. However, due to the expansion of this technology, it has challenges such as high-scale production, selection of printable food, formulation optimization, and food production according to the consumer’s opinion. Food additives (gums, enzymes, proteins, starches, polyphenols, spices, probiotics, algae, edible insects, oils, salts, vitamins, flavors, and by-products) are one of the main components of the formulation that can be effective in food production according to the consumer’s attitude.”

Astrobiology, space biology, microgravity,

Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻