NASA Spaceline Current Awareness List #1,091 15 March 2024 (Space Life Science Research Results)

Papers deriving from NASA support:

1. Kamran SA, Hossain KF, Ong J, Waisberg E, Zaman N, Baker SA, Lee AG, Tavakkoli A.FA4SANS-GAN: A novel machine learning generative adversarial network to further understand ophthalmic changes in spaceflight associated neuro-ocular syndrome (SANS).Ophthalmology Science. 2024 Feb 15;100493. Online ahead of print.PI: A. TavakkoliJournal Impact Factor: 13.7
   
   Funding: “This research was supported by NASA Grant [80NSSC20K183]: A Non intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight.”
2. Marshall-Goebel K, Lee SMC, Lytle JR, Martin DS, Miller CA, Young M, Laurie SS, Macias BR.Jugular venous flow dynamics during acute weightlessness.J Appl Physiol (1985). 2024 Mar 14.Note: From the abstract: “During spaceflight fluids shift headward, causing internal jugular vein (IJV) distension and altered hemodynamics, including stasis and retrograde flow, that may increase the risk of thrombosis. This study’s purpose was to determine the effects of acute exposure to weightlessness (0-G) on IJV dimensions and flow dynamics. We used 2D ultrasound to measure IJV cross-sectional area (CSA) and Doppler ultrasound to characterize venous blood flow patterns in the right and left IJV in 13 healthy participants (6 female) while 1) seated and supine on the ground, 2) supine during 0-G parabolic flight, and 3) supine during level flight (at 1-G).”
   
   Journal Impact Factor: 3.3
   
   Funding: “80JSC019N0001-OMNIBUS/NASA Human Research Program.”
3. Tays GD, Hupfeld KE, McGregor HR, Beltran NE, De Dios YE, Mulder E, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler RD.Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest.npj Microgravity. 2024 Mar 12;10:27.PI: R.D. SeidlerNote: Head-down tilt bedrest study. This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA 80NSSC18K0783) to R.S., A.M., S.W., and J.B. During the completion of this work G.T. was supported by the University of Florida’s (UF) Graduate Student Funding Award and by NIH T32-NS082128. KH was supported by a National Institute on Aging fellowship 1F99AG068440. H.R.M. was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postdoctoral Fellowship and a NASA Human Research Program Augmentation Grant.”
4. Wei F, Hughes M, Omer M, Ngo C, Pugazhendhi AS, Kolanthai E, Aceto M, Ghattas Y, Razavi M, Kean TJ, Seal S, Coathup M.A multifunctional therapeutic strategy using P7C3 as a countermeasure against bone loss and fragility in an ovariectomized rat model of postmenopausal osteoporosis.Adv Sci (Weinh). 2024 Mar 13;e2308698.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 15.1
   
   Funding: “This study was funded by the Department of Internal Medicine, College of Medicine, University of Central Florida (Award #2508074). The authors acknowledge funding from the National Science Foundation (NSF) Major Research Instrumentation (MRI) Program (Grant ID: ECCS:1726636) for the XPS measurements presented in this manuscript. Author CN’s work was supported by the National Aeronautics and Space Administration [grant No. 80NSSC21M0309] issued through the NASA Office of STEM Engagement.”
5. Horitani K, Chavkin NW, Arai Y, Wang Y, Ogawa H, Yura Y, Evans MA, Cochran JD, Thel MC, Polizio AH, Sano M, Miura-Yura E, Arai Y, Doviak H, Arnold AP, Gelfand BD, Hirschi KK, Sano S, Walsh K.Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure.Nat Cardiovasc Res. 2024 Mar 8.PI: K. WalshNote: This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “This work was supported by National Institutes of Health (NIH) grants AG073249 and HL142650 and National Aeronautics and Space Administration grant 80NSSC21K0549 to K.W. …”

Other papers of interest:

1. Cucinotta FA, Schimmerling W.A no-fault risk compensation approach for radiation risks incurred -n space travel.Life Sci Space Res. 2024 Mar 13. Online ahead of print.Note: This is an opinion/position paper. From the abstract: “In this paper we recommend an appropriate compensation approach should be established for fatality and disabilities that may occur due to space radiation exposures of government or industry workers. A brief review of compensation approaches for nuclear energy and nuclear weapons development workers in the United States and other countries is described.”
2. Yoshida K, Hada M, Hayashi M, Kizu A, Kitada K, Eguchi-Kasai K, Kokubo T, Teramura T, Hashizume Suzuki H, Watanabe H, Kondoh G, Nagamatsu A, Saganti P, Muratani M, Cucinotta FA, Morita T.Transcriptome analysis by RNA sequencing of mouse embryonic stem cells stocked on International Space Station for 1584 days in frozen state after culture on the ground.Int J Mol Sci. 2024 Mar 14;25(6):3283.Note: This article is part is Special Issue “Radiation-Induced Non-DNA-Targeted Effects Relevant to Radiation Protection and Medicine” (https://www.mdpi.com/journal/ijms/special_issues/non_DNA_radiation). The Special Issue also includes an article from previous Current Awareness List #1,083 https://doi.org/10.3390/ijms25021015. This article may be obtained online without charge.
3. Kocalar S, Miller BM, Huang A, Gleason E, Martin K, Foley K, Copeland DS, Jewett MC, Saavedra EA, Kraves S.Validation of cell-free protein synthesis aboard the International Space Station.ACS Synth Biol. 2024 Mar 5.Note: ISS results. This article may be obtained online without charge.
4. Guo S, Sun Y, Wu T, Kwok L-Y, Wang J, Zhang H.Metabolic profiling and growth characteristics of a spaceflight-induced mutant of Lacticaseibacillus rhamnosus: Unveiling enhanced carbohydrate and amino acid metabolism for improved probiotic potential.Food Bioscience. 2024 Apr;58:103758.Note: From the abstract: “This study aimed to investigate the molecular-level differences in growth characteristics and metabolism between R7970 and Probio-M9.”
5. Lansiaux E, Jain N, Chodnekar S, Siddiq A, Ibrahim M, Yèche M, Kantane I.Understanding the complexities of space anaemia in extended space missions: Revelations from microgravitational odyssey.Front Physiol. 2024 Mar 10;15:1321468.Note: This a perspective article and may be obtained online without charge.
6. Masalkhi M, Ong J, Waisberg E, Lee AG.Ocular immunology and inflammation under microgravity conditions and the pathogenesis of spaceflight associated neuro-ocular syndrome (SANS).Eye (Lond). 2024 Mar 5.Note: This article is a comment and may be obtained online without charge.
7. Mortazavi A, Yarbaksh H, Zarandi BF, Zarandi B, Yarbakhsh R, Ghadimi-Moghaddam F, Mortazavi SMJ, Haghani M, Firoozi D, Sihver L.Cultivation of vitamin C-rich vegetables for space-radiation mitigation.Radiation. 2024 Mar 8;4(1):101-14. Review.Note: This article is part of Section “Radiation and Its Application in Oncology and Radiation Protection” (https://www.mdpi.com/journal/radiation/sections/Radiation_Application_Oncology_Radiation_Protection) and may be obtained online without charge.
8. Daniells S.Probiotic Bulgarian yogurt “feasible” to achieve good health and well-being on Mars missions.Global Food. 2024 Jan 24.
9. Farooq M, Ali S, Khan M, Jang Y-H, Kim E-G, Zhao D-D, Kim K-M.Investigating plant responses to microgravity and adaptations in gravisensitive environments.Environ Sci Eur. 2024 Feb 13;36:28. Review.Note: This article may be obtained online without charge.
10. Strods A, Narbute K, Movčana V, Gillois K, Rimša R, Hollos P, Rūmnieks F, Spule A, Mozoļevskis G, Abols A.Development of organ-on-a-chip system with continuous flow in simulated microgravity.Micromachines. 2024 Mar 9;15(3):370.Note: A clinostat was used in this study. This article is part of Section “B: Biology and Biomedicine” (https://www.mdpi.com/journal/micromachines/sections/B_Biology) and may be obtained online without charge.
11. Zhou W, Li Y, Hou Y, Dan W, Chen L, Shi F, Zhao F, Fang L.Simulated microgravity increases CD226⁺ Lin^– CD117^– Sca1⁺ mesenchymal stem cells in mice.Physiol Rep. 2024 Mar 11;12(5):e15971.Note: Hindlimb unloading study. This article may be obtained online without charge.
12. Schwanke D, Schüle S, Stewart S, Fatanmi OO, Wise SY, Hackenbroch C, Wiegel T, Singh VK, Port M, Abend M, Ostheim P.Validating a four-gene set for H-ARS severity prediction in peripheral blood samples of irradiated Rhesus Macaques.Radiat Res. 2024 Mar 13. Online ahead of print.
13. Shanshool AS, Ziaee S, Ansari MA, Tuchin VV.Advances in the transport of laser radiation to the brain with optical clearing: From simulation to reality.Prog Quantum Electron. 2024 Mar;94:100506. Review.
14. Liu H, Tian Z, Liu S, Yang W, Qian A, Hu L, Wu Z.Chapter 4 – Mechanobiology of bone marrow mesenchymal stem cells (BM-MSCs).In: Qian A, Hu L, editors. Bone Cell Biomechanics, Mechanobiology and Bone Diseases: Academic Press, 2024. p. 97-124.
15. Li X, Zhao R, Liu J, Li Z, Chen A, Xu S, Sheng X.Dynamic changes in calcium signals during root gravitropism.Plant Physiol Biochem. 2024 Mar;208:108481.
16. Wexler Y, Schroeder JI, Shkolnik D.Hydrotropism mechanisms and their interplay with gravitropism.Plant J. 2024 Feb 23. Review. Online ahead of print.Note: This article may be obtained online without charge.

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