NASA Spaceline Current Awareness List #1,059 21 July 2023 (Space Life Science Research Results)

Papers deriving from NASA support:

1. Scott A, Willis CRG, Muratani M, Higashitani A, Etheridge T, Szewczyk NJ, Deane CS.Caenorhabditis elegans in microgravity: An omics perspective.iScience. 2023 Jul 21;26(7):107189. Review.Note: From the abstract: “The application of omics to study Caenorhabditis elegans (C. elegans) in the context of spaceflight is increasing, illuminating the wide-ranging biological impacts of spaceflight on physiology. In this review, we highlight the application of omics, including transcriptomics, genomics, proteomics, multi-omics, and integrated omics in the study of spaceflown C. elegans, and discuss the impact, use, and future direction of this branch of research. We highlight the variety of molecular alterations that occur in response to spaceflight, most notably changes in metabolic and neuromuscular gene regulation.” This article may be obtained online without charge.
   
   Journal Impact Factor: 5.8
   
   Funding: “T.E., N.J.S., and C.S.D. are members of the European Space Agency-funded Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/ NASA –omics database for spaceflight and ground facilities experiments.” N.J.S. was supported by grants from NASA [NSSC22K0250; NSSC22K0278] and acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine. C.S.D. was supported by a Medical Research Council Skills Development Fellowship (MR/T026014/1).”
2. Smith E, Fitzgerald J, Tomkinson G, De Leon P, Rhoades J, Orr S.Reduced gravity effects on gait coordinative structures.Life Sci Space Res. 2023 Aug 1;38:59-66.Note: From the abstract: “This study examined gait patterns under 1.0 g (Earth), simulated 0.38 g (Martian), and 0.17 g (Lunar). Participants walked and ran on a treadmill supported by ARGOS (Active Response Gravity Offload System), simulating fractional gravity. Vicon motion capture data and principal component analysis software were used to capture and quantify coordinated gait structures.”
   
   Journal Impact Factor: 2.5
   
   Funding: “Support was received from the University of North Dakota Department of Space Studies, Department of Education, Health and Behavior Studies, The Human Spaceflight Laboratory, and the BiPed Laboratory, as well as the North Dakota Space Grant Consortium, all of which are located in Grand Forks, ND, US. Partial funding was made possible through the NonReimbursable Space Act Umbrella Agreement between The NASA Lyndon B. Johnson Space Center and the University of North Dakota for SAA…”
3. Allred AR, Kravets VG, Ahmed N, Clark TK.Modeling orientation perception adaptation to altered gravity environments with memory of past sensorimotor states.Front Neural Circuits. 2023 Jul 20;17:1190582.Note: This article and an article below (Gammeri et al.) in the “Other” section are part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (https://www.frontiersin.org/research-topics/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,041 https://doi.org/10.3389/fphys.2023.1141078, #1,046 https://doi.org/10.3389/fncir.2023.1135434, #1,051 https://doi.org/10.3389/fphys.2023.1146096, # 1,053 https://doi.org/10.3389/fphys.2023.1141015, #1,056 https://doi.org/10.3389/fnins.2023.1180314. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.5
   
   Funding: “This work was supported by a NASA Space Technology Graduate Research Opportunities Award.”
4. Matei B, Winters-Stone KM, Raber J.Examining the mechanisms behind exercise’s multifaceted impacts on body composition, cognition, and the gut microbiome in cancer survivors: Exploring the links to oxidative stress and inflammation.Antioxidants. 2023 Jul 14;12(7):1423.Note: This article is part of Section “Health Outcomes of Antioxidants and Oxidative Stress” (https://www.mdpi.com/journal/antioxidants/sections/health_outcomes_antioxidants_oxidative_stress) and may be obtained online without charge.
   
   Journal Impact Factor: 7.0
   
   Funding: “This research was partially funded by NASA 80NSSC19K0498-P00001 and an OHSU Knight Cancer Center CCSG award.”
5. Qin J, Monje O, Nugent MR, Finn JR, O’Rourke AE, Wilson KD, Fritsche RF, Baek I, Chan DE, Kim MS.A hyperspectral plant health monitoring system for space crop production.Front Plant Sci. 2023 Jul 4;14:1133505.Note: This article is part of Research Topic “Machine Vision and Machine Learning for Plant Phenotyping and Precision Agriculture” (https://www.frontiersin.org/research-topics/44964/machine-vision-and-machine-learning-for-plantphenotypingand-precision-agriculture#overview) and may be obtained online without charge.
   
   Journal Impact Factor: 5.6
   
   Funding: O. Monje, M.R. Nugent, J.R. Finn, A.E. O’Rourke, K.D. Wilson, and R.F. Fritsche are affiliated with NASA Kennedy Space Center.
6. Malone SK, Matus AM, Flatt AJ, Peleckis AJ, Grunin L, Yu G, Jang S, Weimer J, Lee I, Rickels MR, Goel N.Prolonged use of an automated insulin delivery system improves sleep in long-standing type 1 diabetes complicated by impaired awareness of hypoglycemia.J Diabetes Sci Technol. 2023 Jul 14;19322968231182406. Online ahead of print.PI: N. GoelJournal Impact Factor: 5.0
   
   Funding: “NASA grants 80NSSC20K0243 and NNX14AN49G.”

Other papers of interest:

1. Alon DM, Mittelman K, Stibbe E, Countryman S, Stodieck L, Doraisingam S, Leal Martin DM, Hamo ER, Pines G, Burstein D.CRISPR-based genetic diagnostics in microgravity.Biosens Bioelectron. 2023 Jul 5;237:115479. Online ahead of print.Note: ISS results.
2. Albornoz-Miranda M, Parrao D, Taverne M.Sleep disruption, use of sleep-promoting medication and circadian desynchronization in spaceflight crewmembers: Evidence in low-Earth orbit and concerns for future deep-space exploration missions.Sleep Medicine: X. 2023 Jul 7;100080. Review. Online ahead of print.Note: From the article: “The aim of this review is to collect evidence of sleep disruption and fatigue in astronauts in recent years, identify the use of sleep-promoting medication in astronauts, and deepen the comprehension of challenges to sleep physiology for future missions to the Moon and Mars.”
3. Schlaff CD, Helgeson MD, Wagner SC.Pathophysiologic spine adaptations and countermeasures for prolonged spaceflight.Clin Spine Surg. 2023 Jul 17. Online ahead of print.Note: This article is a narrative review.
4. Stepanek J, Blue RS, Connolly D.Pulmonary function in human spaceflight.Semin Respir Crit Care Med. 2023 Jul 17. Review. Online ahead of print.
5. Gammeri R, Salatino A, Pyasik M, Cirillo E, Zavattaro C, Serra H, Pia L, Roberts DR, Berti A, Ricci R.Modulation of vestibular input by short-term head-down bedrest affects somatosensory perception: Implications for space missions.Frontiers in Neural Circuits. 2023 Jul 13;17:1197278.Note: Head-down tilt bedrest study. This article and an article above (Allred et al.) in the “NASA” section are part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior-Volume II” (https://www.frontiersin.org/research-topics/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). This article may be obtained online without charge.
6. Cao G, Concas A, Orrù R, Licheri R, Sani E, Dell’Oro A, Fais G, Manis C, Manca A, Uras G, Caboni P, Locci AM, Cincotti A, Lai N, Congiu T, Faa G, Pisu M, Brelstaff G, Pantaleo A.Recent advances on ISRU [In-Situ Resource Utilization] technologies and study of microgravity impact on blood cells for deep space exploration.Front Space Technol. 2023 Jul 1919;4:1146461. Review.
7. Niclou A, Sarma M, Levy S, Ocobock C.To the extreme! How biological anthropology can inform exercise physiology in extreme environments.Comp Biochem Physiol A Mol Integr Physiol. 2023 Oct;248:111476.
8. Zhang W, Zhang J, Cui Y, Zhao Y, Lei X.Stem cells and exosome applications for cutaneous wound healing: From ground to microgravity environment.Stem Cell Rev Rep. 2023 Jul 17. Review.
9. Mu Y, Wei D, Yao L, Xu X, Li S, Cao R, Chen T, Zhang Z.Choroidal circulation disturbance is an initial factor in outer retinal degeneration in rats under simulated weightlessness.Front Physiol. 2023 Jul 20;14:1198862.Note: This article is part of Research Topic “Insights in Environmental, Aviation and Space Physiology: 2022” (https://www.frontiersin.org/research-topics/34248/insights-in-environmental-aviation-and-space-physiology-2022#overview). The Research Topic also includes articles from previous Current Awareness Lists #1,003 https://doi.org/10.3389/fphys.2022.907651; #1,022 https://doi.org/10.3389/fphys.2022.1007316 and https://doi.org/10.3389/fphys.2022.1003073; #1,026 https://doi.org/10.3389/fphys.2022.1029161; #1,028 https://doi.org/10.3389/fphys.2022.1008508; and #1,057 https://doi.org/10.3389/fphys.2023.1199175. This article may be obtained online without charge.
10. Devlin-Hegedus J, Miller M, Cooke S, Ware S, Richmond C.Measured task load in directed observers versus active participants undergoing high-fidelity simulation education in a critical care setting.AEM Educ Train. 2023 Jul 11;7(4):e10894.Note: NASA Task Load Index was used in this study.

Astrobiology, Space Biology,