SPACELINE Current Awareness List

NASA Spaceline Current Awareness List #1,058 14 July 2023 (Space Life Science Research Results)

By Keith Cowing
Status Report
July 14, 2023
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NASA Spaceline Current Awareness List #1,058 14 July 2023 (Space Life Science Research Results)
Microbiologist and astronaut Kate Rubins examines stem cell–derived heart muscle cells aboard the International Space Station. NASA

In case you missed it: New Scientist magazine recently published a Commentary written by Dr. Elisa Raffaella Ferrè titled “We must address a key obstacle to our new age of space exploration.” “Advances in rocket technology are exciting, but we need to investigate how non-terrestrial gravity affects astronauts’ psychology and cognition,” says neuroscientist Elisa Raffaella Ferrè. The Commentary is available with a subscription at

Papers deriving from NASA support:

  1. Zheng M, Charvat J, Zwart SR, Mehta SK, Crucian BE, Smith SM, He J, Piermarocchi C, Mias GI.Time-resolved molecular measurements reveal changes in astronauts during spaceflight.Front Physiol. 2023 Jul 14;14:1219221.PI: G.I. MiasNote: ISS results. From the article: “Forty-seven potential subjects were identified as United States (US) astronauts that flew across 32 ISS and space shuttle expeditions and participated in two studies on Nutritional Status Assessment (SMO 016E), and Validation of Procedures for Monitoring Crewmember Immune Function (SMO 015). Thirty-eight astronauts agreed to participate following informed consent, and the analysis presented in this manuscript focuses on 27 subjects (19 male and 8 female) for whom long-duration measurements on the ISS were available (mean-based duration 165 days). Data for these subjects were obtained from LSAH and the Life Sciences Data Archive (LSDA).” This article may be obtained online without charge.

    Journal Impact Factor: 4

    Funding: “This project was supported by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A (project T0412, PI: GM). CP acknowledges support by NIH R01GM122085. The Nutritional Status Assessment SMO (PI: SS) and the Validation of Procedures for Monitoring Crewmember Immune Function (PI: BC) were supported by the NASA Human Research Program Human Health Countermeasures Element.”
  2. McGregor HR, Lee JK, Mulder ER, De Dios YE, Beltran NE, Wood SJ, Bloomberg JJ, Mulavara AP, Seidler RD.Artificial gravity during a spaceflight analog alters brain sensory connectivity.Neuroimage. 2023 Jul 6;120261. Online ahead of print.PIs: H.R. McGregor, R.D. SeidlerNote: Head-down tilt bedrest study.

    Journal Impact Factor: 5.7

    Funding: “NASA grant #80NSSC18K0783. HRM was supported by a NSERC postdoctoral fellowship and a NASA Human Research Program augmentation grant.”
  3. Flickinger KL, Weissman A, Elmer J, Coppler PJ, Guyette FX, Repine MJ, Dezfulian C, Hopkins D, Frisch A, Doshi AA, Rittenberger JC, Callaway CW.Metabolic manipulation and therapeutic hypothermia.Ther Hypothermia Temp Manag. 2023 Jul 3. Online ahead of print.PI: C.W. CallawayNote: From the abstract: “Hypothermia has multiple physiological effects, including decreasing metabolic rate and oxygen consumption (VO2). There are few human data about the magnitude of change in VO2 with decreases in core temperature. We aimed to quantify to magnitude of reduction in resting VO2 as we reduced core temperature in lightly sedated healthy individuals.”

    Journal Impact Factor: 1.2

    Funding: “This study was funded in part by the Translational Research Institute through NASA (NNX16AO69A).”
  4. Torres RD, Rashed H, Mathur P, Castillo C, Abell T, Terson de Paleville DGL.Autogenic biofeedback training improves autonomic responses in a participant with cervical motor complete spinal cord injury-Case report.Spinal Cord Ser Cases. 2023 Jul 12;9(1):31.Journal Impact Factor: 1.2

    Funding: “The material is based upon work supported by NASA Kentucky under NASA award number 80NSSC20M0047.”
  5. Wesolowski LT, Simons JL, Semanchik PL, Othman MA, Kim J-H, Lawler JM, Kamal KY, White-Springer SH.The impact of SRT2104 on skeletal muscle mitochondrial function, redox biology, and loss of muscle mass in hindlimb unloaded rats.Int J Mol Sci. 2023 Jul 6;24(13):11135.PI: J.M. LawlerNote: Hindlimb unloading study. This article is part of Special Issue “Cellular and Molecular Signaling Meet the Space Environment” ( The editorial includes articles from Current Awareness lists #983; #1,002 and; #1,008 and; and #1,054 This article may be obtained online without charge.

    Journal Impact Factor: 5.6

    Funding: “This research was generously funded by NASA (80NSSC19K0432, NNX13AE45G) to J.M.L., the Huffines Institute at Texas A&M University to (J.M.L., K.Y.K.).”

Other papers of interest:

  1. Stratis D, Trudel G, Rocheleau L, Pelchat M, Laneuville O.The transcriptome response of astronaut leukocytes to long missions aboard the International Space Station reveals immune modulation.Front Immunol. 2023 Jun 22;14:1171103.Note: ISS results. This article is part of Research Topic “Artificial Intelligence in Predicting, Determining, and Controlling Cell Phenotype or Tissue Function in Inflammatory Diseases” ( Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
  2. Liu X, Du Y, Xu C, Wang F, Li X, Liu L, Ma X, Wang Y, Ge L, Ren W, Jin L, Zhou L.Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and x-rays.Life Sci Space Res. 2023 Aug;38:87-100.Note: From the abstract: “The response of plants to radiation is an essential topic in both space plant cultivation and mutation breeding by radiation. In this study, heavy ion beams (HIB) generated by the ground accelerator and x-rays (XR) were used as models of high linear energy transfer (LET) and low LET radiation to study the molecular response mechanism of Platycodon grandiflorus (P. grandiflorus) seedlings after irradiation.”
  3. Van Ombergen A, Chalupa-Gantner F, Chansoria P, Colosimo BM, Costantini M, Domingos M, Dufour A, De Maria C, Groll J, Jungst T, Levato R, Malda J, Margarita A, Marquette C, Ovsianikov A, Petiot E, Read S, Surdo L, Swieszkowski W, Vozzi G, Windisch J, Zenobi-Wong M, Gelinsky M.3D bioprinting in microgravity: Opportunities, challenges, and possible applications in space.Adv Healthcare Mater. 2023 Jun 23;2300443. Online ahead of print.Note: From the abstract: “3D bioprinting has developed tremendously in the last couple of years and enables the fabrication of simple, as well as complex, tissue models. The international space agencies have recognized the unique opportunities of these technologies for manufacturing cell and tissue models for basic research in space, in particular for investigating the effects of microgravity and cosmic radiation on different types of human tissues. In addition, bioprinting is capable of producing clinically applicable tissue grafts, and its implementation in space therefore can support the autonomous medical treatment options for astronauts in future long term and far-distant space missions. The article discusses opportunities but also challenges of operating different types of bioprinters under space conditions, mainly in microgravity. While some process steps, most of which involving the handling of liquids, are challenging under microgravity, this environment can help overcome problems such as cell sedimentation in low viscous bioinks. Hopefully, this publication will motivate more researchers to engage in the topic, with publicly available bioprinting opportunities becoming available at the International Space Station (ISS) in the imminent future.” This article may be obtained online without charge.
  4. Giacinto O, Garo ML, Pelliccia F, Minati A, Chello M, Lusini M.Heart disease and microgravity: The dawn of a new medical era?: A narrative review.Cardiol Rev. 2023 Jul 10. Online ahead of print.Note: From the abstract: “After a decline in interest in space missions following the cessation of the Apollo missions, there has been a recent resurgence. Activities on the International Space Station have raised awareness of a positive resumption of space travel to more challenging destinations such as Mars and a possible adaptation of human life on the Moon. The biological and physiological studies conducted on these stations in low Earth orbit are crucial in familiarizing humanity with the potential problems that can arise during long journeys. Cosmic rays and microgravity are the two main negative phenomena in space flights. Microgravity in the interplanetary environment plays a special role in altering normal organic processes. These studies are compared to studies conducted on Earth with laboratory technologies that mimic the space environment. To date, the molecular and physiological adaptations of the human body to this unnatural environment are very poor. The aim of this review is therefore to provide an overview of the most important findings on the molecular and physiological anomalies that develop during microgravity in short and long space flights.”
  5. Yoshikawa M, Matsukawa M, Oshima H, Ishikawa C, Li H, Kudo T, Shiba D, Shirakawa M, Muratani M, Takahashi S, Uemura M, Aizawa S, Shiga T.Comparing the effects of microgravity and amyotrophic lateral sclerosis on mouse dorsal root ganglia.Front Space Technol. 2023 Jul 3;1162268.Note: Results of centrifugation in the International Space Station. This article may be obtained online without charge.
  6. Liu M, Lan Y, Qin Y, Gao Y, Deng Y, Li N, Zhang C, Ma H.Interaction between astrocytes and neurons in simulated space radiation-induced CNS injury.Int J Radiat Biol. 2023 Jul 12;1-11. Online ahead of print.
  7. Price C, Russell JA.AMAnD: An automated metagenome anomaly detection methodology utilizing DeepSVDD neural networks.Front Public Health. 2023 Jul 11;11:1181911.Note: This article is part of Research Topic “Fast Transit, Crew Health, and Performance on Extended Duration Space Missions” ( The Research Topic also includes an article from previous Current Awareness List #1,053 This article may be obtained online without charge.
  8. Song H, Shim WM, Rosenberg MD.Large-scale neural dynamics in a shared low-dimensionalstate space reflect cognitive and attentional dynamics.Elife. 2023 Jul 3;12:e85487. Online ahead of print.Note: This article may be obtained online without charge.
  9. Ranade A, Khan AA, Gul MT, Suresh S, Qaisar R, Ahmad F, Karim A.Suppression of endoplasmic reticulum stress reverses hindlimb unloading-induced hepatic cellular processes in mice.Biochim Biophys Acta Gen Subj. 2023 Jul 3;130422.Note: Hindlimb unloading study.
  10. Sharlo KA, Lvova ID, Tyganov SA, Sergeeva KV, Kalashnikov VY, Kalashnikova EP, Mirzoev TM, Kalamkarov GR, Shevchenko TF, Shenkman BS.A prochlorperazine-induced decrease in autonomous muscle activity during hindlimb unloading is accompanied by preserved slow myosin mRNA expression.Curr Issues Mol Biol. 2023 Jun 30;45(7):5613-30.Note: Hindlimb unloading study. This article is part of Special Issue “Studying the Function of RNAs Using Omics Approaches” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.

Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻