NASA Spaceline Current Awareness List #1,141 21 March 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Lee R, Ong J, Waisberg E, Mader T, Berdahl J, Suh A, Panzo N, Memon H, Sampige R, Katsev B, Kadipasaoglu CM, Mason CE, Beheshti A, Zwart SR, Smith SM, Lee AG.Potential risks of ocular molecular and cellular changes in spaceflight.Semin Ophthalmol. 2025 Mar 17;1-11. Review.Journal Impact Factor: 1.9
   
   Funding: “SMS and SRZ are funded by the NASA Human Research Program.”
2. Lee JD, Kumar A, Mathur T, Jain A.Vascular architecture-on-chip: Engineering complex blood vessels for reproducing physiological and heterogeneous hemodynamics and endothelial function.Lab Chip. 2025 Mar 11. Online ahead of print.PI: A. JainNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 6.1
   
   Funding: “This material is based upon work supported by the US Army Medical Research (USAMRAA) Contract No. HT94252410432; NASA, BARDA, NIH, and USFDA, under Contract No. 80ARC023CA002; NHLBI of NIH under Award Number R01HL157790; NSF CAREER Award number 1944322; and TAMU Office of Innovation Translational Investment Funds to A. J.”
3. Cooke JP.From the masters: How RNA drugs will transform vascular medicine.Vasc Med. Mar 3;1358863X251323275. Online ahead of print.Note: This article is an editorial and may be obtained online without charge.
   
   Journal Impact Factor: 3.0
   
   Funding: “This work was supported in part by federal grants (R01 HL148338, R01 HL157790; NASA Contract #80ARC023CA002) and funding from the Joseph C ‘Rusty’ Walter and Carole Walter Looke Presidential Distinguished Chair.”
4. Swinkels PJM, Gong Z, Sacanna S, Meyer WV, Schall P.Colloidal molecules in microgravity assembled by critical Casimir forces.Gravit Space Res. 2025 Mar 13;13(1):21-9.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.0
   
   Funding: W.V. Meyer is affiliated with NASA Glenn Research Center.

Other papers of interest:

1. Panzo N, Memon H, Ong J, Suh A, Sampige R, Lee R, Waisberg E, Kadipasaoglu CM, Berdahl J, Chévez-Barrios P, Lee AG.Molecular and biomechanical changes of the cornea and lens in spaceflight.Life Sci Space Res. 2025 Mar 15. Review. Online ahead of print.
2. Akbarialiabad H, Jamshidi P, Aminzade Z, Azizi N, Taha SR, Sadeghian N, Varghese LJK, Kouhanjani MF, Niknam N, Babocs D, El-Assaad F, Russomano T, Murrell DF, Paydar S, Bunick CG, Christiansen R, Mark Melin M.Leveraging space innovations for cancer breakthroughs on Earth.Trends Cancer. 2025 Mar 12. Review. Online ahead of print.
3. Bosutti A, Ganse B, Maffiuletti NA, Wüst RCI, Strijkers GJ, Sanderson A, Degens H.Microgravity-induced changes in skeletal muscle and possible countermeasures: What we can learn from bedrest and human space studies.Exp Physiol. 2025 Mar 17.Note: Head-down tilt bedrest study. This article may be obtained online without charge.
4. Hatsuda M, Hasegawa M, Nakamura K, Yamakura F, Kobayashi T, Takanashi T, Wakabayashi Y, Otake Y, Naito T, Daida H.Effects of neutron radiation on pharmaceuticals in deep space-like environments – general anesthesia in space.Life Sci Space Res. 2025 Mar 15. Online ahead of print.Note: From the abstract: “In deep space environments such as the Moon and Mars, secondary radiation generated by interactions between galactic cosmic rays and spacecraft walls or planetary surfaces presents a significant challenge. In particular, the effects of neutron radiation remain insufficiently understood. This study investigates the impact of neutron radiation on pharmaceuticals, specifically the general anesthetic propofol (2,6-Diisopropylphenol).”
5. Ikewaki N, Ichiyama K, Senthilkumar R, Preethy S, Abraham SJK.Modulation of neutrophil-to-lymphocyte ratio and gut microbiome balance in astronauts: Potential benefits of novel beta-glucans during space missions.Front Immunol. 2025 Mar 2;16:1538147.Note: This is an opinion article and may be obtained online without charge.
6. Mu Y, Li W, Wei D, Zhang X, Yao L, Xu X, Wang X, Zhang Z, Chen T.The effect of hydrogen-rich water on retinal degeneration in the outer nuclear layer of simulated weightlessness rats.Life Sci Space Res. 2025 Mar 16. Online ahead of print.Note: Hindlimb unloading study.
7. Prakash P, Weerasinghe J, Levchenko I, Prasad K, Alexander K.Polyimide nanocomposites for next generation spacesuits.Mater Horiz. 2025 Mar 17. Review. Onine ahead of print.Note: From the abstract: “This review explores the opportunities that emerge when the desirable properties of polyimides are combined with that of nanomaterials, specifically carbon nanomaterials, to produce strategic material combinations that promise to achieve enhanced thermal and mechanical properties, improved resistance to abrasion and puncture, and potentially reduced weight compared to traditional spacesuit materials. In turn, these advancements will contribute to the development of next-generation spacesuits that offer superior comfort, protection, and astronaut mobility during extravehicular activities.”
8. Ryumin OO, Ivanov AV.[Space exploration mission: Psychological safety of the crew].Aviakosm Ekolog Med. 2025;59(1). Russian.
9. Shafirkin AV, Benguin VV, Shurshakov VA.[Local tissue doses during a mission beyond Earth’s magnetosphere with various spacecraft shielding taking into account the decrease of the effectiveness of proton and helium ions].Aviakosm Ekolog Med. 2025;59(1). Russian.
10. Supolkina NS, Yusupova AK, Kotov OV, Savenko OA.[Algorithm for modeling effective communication between the MCC and space crew based on content-analysis of communications data of cosmonauts with ground controllers during space missions].Aviakosm Ekolog Med. 2025;59(1). Russian.
11. Borromeo I, Mentana A, Baiocco G, Beninati S, Boretti V, Cappadozzi G, Fino LD, Facoetti A, Lunati L, Paci M, Pinto M, Pullia M, Rizzo A, Amantini GS, Toma S, Narici L.Activation of the visual system by space radiation: A novel study on Ca²⁺ signalling in ex-vivo rabbit eyes exposed to visible light, X-rays and high-energy protons.Life Sci Space Res. 2025 Mar 17. Online ahead of print.
12. Kharin SA, Poddubko SV, Rodimin VD, Shef KA, Dymova AA, Berkovich YA, Beliak AM, Smolianina SO.[Cultivation of plants in space greenhouse Vitatsikl-T as a factor influencing microbiological parameters within the environment of habitable space complexes].Aviakosm Ekolog Med. 2025;59(1). Russian.
13. Fan H, Lü D, Lu Z, Li H, Qi Z, Sun S, Guan D, Long M, Gao M, Liu S.TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.npj Microgravity. 2025 Mar 15;11(1):9.Note: From the abstract: “Here, Rotating Flat Chamber (RFC) was used to simulate ground-based microgravity effects to study how microgravity effects affect the differentiation of HepaRG (hepatic progenitor cells) cells.” This article may be obtained online without charge.
14. Ikeda Y, Funamoto M, Yamamoto M, Ly-Nguyen HD, Imanishi M, Tsuchiya K.Changes of iron dynamics in the duodenum and bone marrow under partial gravity conditions in mice.Life Sci Space Res. 2025 Mar 19. Online ahead of print.
15. Gornostaeva AN, Buravkova LB.[Characteristics of the extracellular matrix of adipose stromal progenitor cells after a long-term simulation of microgravity].Aviakosm Ekolog Med. 2025;59(1). Russian.
16. Grimm D, Corydon TJ, Sahana J, González-Torres LF, Kraus A, Marchal S, Wise PM, Simonsen U, Krüger M.Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids.Stem Cells Transl Med. 2025 Mar 18;14(3):szaf008. Review.Note: This article may be obtained online without charge.
17. Wang D, Silvani G, Schroeter L, Brynn R, Chou J, Poole K.The mechanosensitive channel ELKIN1 regulates cellular adaptations to simulated microgravity.npj Microgravity. 2025 Mar 16;11:10.Note: A random positioning machine was used in this study to simulate microgravity. This article may be obtained online without charge.
18. Holyer A, Stewart T, Ashworth ET.The protective effects of hyperbaric oxygen on ionizing radiation injury: A systematic review.Acta Astronaut. 2025 Mar 18. Review. Online ahead of print.
19. Druzhinina AA, Bogotskoy KA, Tarasova OS.[Study of the mechanisms of nitric oxide-dependent control of the cerebral circulation in hypercapnia].Aviakosm Ekolog Med. 2025;59(1). Russian.
20. Kashirina DN, Brzhozovsky AG, Poddubko SV, Dymova AA, Pastushkova LK, Larina IM, Orlov OI.[Effect of hypomagnetic environment on the cell proteome of bacterial cultures].Aviakosm Ekolog Med. 2025;59(1). Russian.
21. Puchkasov LV, Daudi DI, Krivosheev DM, Gan ЕО.[Effect of stratosphere conditions on survivability of bacteria Bacillus subtilis and Bacillus licheniformis].Aviakosm Ekolog Med. 2025;59(1). Russian.
22. Wang L, Tao W, Jia J, Yuan M, Li W, Zhang P, Chen X.The loss of HJV aggravates muscle atrophy by promoting the activation of the T βRII/Smad3 pathway.Int J Mol Sci. 2025 Feb 26;26(5):2016.Note: This article is part of Section “Molecular Biology” (https://www.mdpi.com/journal/ijms/sections/Molecular_Biology) and may be obtained online without charge.
23. Chen X, Wang J, Zhen C, Zhang G, Yang Z, Xu Y, Shang P.Hepcidin knockout exacerbates hindlimb unloading-induced bone loss in mice through inhibiting osteoblastic differentiation.BMC Musculoskelet Disord. 2025 Mar 18;26(1):276.Note: This article may be obtained online without charge.
24. Zhang Y, Miao H, Wang C, Wu B, Chen X, Chi L.Effects of acute sleep deprivation on post-error adjustments and error processing.Int J Psychophysiol. 2025 May;211:112554.
25. Hao Y, Zhang Z, Luo E, Yang J, Wang S.Plant metabolomics: Applications and challenges in the era of multi-omics big data.aBIOTECH. 2025 Mar;6(1):116-32. Review.Note: This article may be obtained online without charge.
26. Liang H, Wang Y, Jiang L, Yu X, Xiong L, Luo L, Fu L, Zhang Y, Li Y, Song J, Sun F.Machine learning-based non-invasive continuous dynamic monitoring of human core temperature with wearable dual temperature sensors.Physiol Meas. 2025 Mar 11. Online ahead of print.Note: From the abstract: “Due to the growing demand for personal health monitoring in extreme environments, continuous monitoring of core temperature has become increasingly important. Traditional monitoring methods, such as mercury thermometers and infrared thermometers, may have limitations in tracking real-time fluctuations in core temperature, especially in special application scenarios such as firefighting, military, and aerospace. This study aims to develop a non-invasive, continuous core temperature prediction model based on machine learning, addressing the limitations of traditional methods in extreme environments.” This article may be obtained online without charge.

astrobiology, space biology, space medicine, microgravity,