NASA Spaceline Current Awareness List #1,139 7 March 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Salido RA, Zhao HN, McDonald D, Mannochio-Russo H, Zuffa S, Oles RE, Aron AT, El Abiead Y, Farmer S, González A, Martino C, Mohanty I, Parker CW, Patel L, Portal Gomes PW, Schmid R, Schwartz T, Zhu J, Barratt MR, Rubins KH, Chu H, Karouia F, Venkateswaran K, Dorrestein PC, Knight R.The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns.Cell. 2025 Feb 27. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 45.5
   
   Funding: C.W. Parker and K. Venkateswaran are affiliated with NASA Jet Propulsion Laboratory. M.R. Barratt and K.H. Rubins are affiliated with NASA Johnson Space Center. F. Karouia is affiliated with NASA Ames Research Center.
2. Ramsburg CF, Wood SJ, Lackner JR, Moynihan S, Reschke MF, Denise P, Clément G.Potential benefits and human systems integration of parastronauts with bilateral vestibulopathy for a space mission.Front Neurol. 2025 Mar 4;16:1556553. Review.Note: This article is part of Research Topic “Impact of Vestibular Dysfunction Studies on Space Flight Health Challenges” (https://www.frontiersin.org/research-topics/53190/impact-of-vestibular-dysfunction-studies-on-space-flight-health-challenges). The Research Topic also includes an article from previous Current Awareness List #1,075 https://doi.org/10.3389/fneur.2023.1284029. This article may be obtained online without charge.
   
   Journal Impact Factor: 2.7
   
   Funding: “The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The National Aeronautics and Space Administration (NASA) provided funding for this study.”
3. Rempe MJ, Rasmussen I, Gregory K, Johnson C, Hsin M, Flynn-Evans E, Lamp A, Hilditch CJ.Layover start timing predicts layover sleep quantity and timing on long-range and ultra-long-range trips.Sleep Adv. 2025;6(1):zpaf002.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 0.8
   
   Funding: K. Gregory and E. Flynn-Evans are affiliated with NASA Ames Research Center.
4. Polizio AH, Marino L, Rolauer L, Doviak H, Grandoch M, Toldo S, Walsh K.Clonal hematopoiesis increases hypertension and sympathetic activity and is reversed by renal denervation.Hypertension. 2025 Feb 19;82(3):e28-e30.PI: K. WalshJournal Impact Factor: 7.2
   
   Funding: “This study was supported by the National Institutes of Health (NIH) grants AG073249, HL142650, HL152174, The National Aeronautics and Space Administration (NASA) grant 80NSSC21K0549, and Department of Defense grant CA210887P2 to K. Walsh; NIH grants HL150115 and HL174999 to S. Toldo; and Deutsche Forschungsgemeinschaft (German Research Foundation; International Research Training Group [IRTG] 1902 Intra- and Interorgan Communication of the Cardiovascular System [TP12, grant number 220652768] and TRR259 Aortic Disease [TP B08, grant number 397484323] to M. Grandoch.”

Other papers of interest:

1. Aviv A, Verhulst S.Telomeres in Space.Aging Cell. 2025 Mar 1;e70030.Note: From the abstract: “Recent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes. Since leukocyte telomere length is associated with aging-related diseases and longevity in humans, it is crucial to understand the underlying factors driving telomere length changes in space.” This article may be obtained online without charge.
2. Savage N.Eye problems cloud NASA’s vision of Mars.Nature. 2025 Mar 5;639(8053):S2-s3.Note: This article may be obtained online without charge.
3. St-Martin P, Lalonde F, Bouchard-Lévesque F, Dionne IJ.Occupational physical requirements for astronauts.Aerosp Med Hum Perform. 2025 Mar 1;96(3):234-50.Note: From the abstract: “The aim of this systematic review is to provide an updated overview of the scientific literature on astronaut occupational tasks and physiological requirements.”
4. Holland DA.Chapter 12 – Insights into spaceflight team performance gleaned from the exploration of challenging environments on Earth.In: Schmidt MA, Legato MJ, eds. Building a Space-Faring Civilization. Academic Press, 2025. p. 125-48.
5. Wei L C, L, Xiaodong Z, Hongbo MA, Xinxing HE, Pengfei Z, Jinxue F.[Risk analysis of solar proton events for astronauts’ radiation dose].Space Med Med Eng. 2024 (6). Chinese.
6. Yongkang T QB, Junfeng W, Runze Y, Zuozuo S, Guojing L, Weidang A, Minzheng S.[Preliminary investigation on the verification of the growth and cultivation of several fruit and vegetable crops on the Chinese Space Station].Space Med Med Eng. 2024 (6). Chinese.
7. Cho TJ, Rhee MS.Space food production on microbiological safety: Key considerations for the design of Hazard Analysis and Critical Control Points (HACCP) plan.Adv Food Nutr Res. 2025;113:287-381.
8. Yuan J, Zhang W, Dang L, Song Y, Yin Z, He Z, Xu K, Guo P, Yin H.Niallia tiangongensis sp. nov., isolated from the China Space Station.Int J Syst Evol Microbiol. 2025 Mar 3;75(3).
9. Bai Y, Wu Z, Leary SC, Fang C, Yu M, Genth H, Xie Y, Shi J, Xiang J.Focal adhesion kinase alleviates simulated microgravity-induced inhibition of osteoblast differentiation by activating transcriptional Wnt/β-catenin-BMP2-COL1 and metabolic SIRT1-PGC-1α-CPT1A pathways.Int J Mol Sci. 2025 Feb 15;26(4):1669.Note: From the article: “The SMG environment was simulated by a three-dimensional clinostat random positional machine (RPM) from the Center for Space Science and Applied Research (Chinese Academy of Sciences, Beijing, China).” This article is part of Special Issue “25th Anniversary of IJMS: Advances in Biochemistry” (https://www.mdpi.com/journal/ijms/special_issues/21st_Biochem) and may be obtained online without charge.
10. Genchi GG, Conci C, Şen Ö, Nardini A, Bartolucci M, Marino A, Martinez Vazquez R, Cerullo G, Osellame R, Petretto A, Raimondi MT, Ciofani G.Two-photon polymerization of miniaturized 3D scaffolds optimized for studies on glioblastoma multiforme in spaceflight-like microgravity conditions.Biofabrication. 2025 Feb 27. Online ahead of print.Note: This article may be obtained online without charge.
11. Liu X, Zhang H, Yan J, Ye P, Wang Y, Zhang N, Tian Z, Liu B, Yang H.Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity.Stem Cell Res Ther. 2025 Mar 5;16(1):115.Note: Hindlimb unloading study. This article may be obtained online without charge.
12. Toussaint TD, Pypaert JM, Gambelli CN, Schepens B.Alterations in the intersegmental coordination of landing from a jump in a microgravity environment.J Appl Physiol (1985). 2025 Feb 28.Note: From the abstract: “The objective is to investigate the intersegmental coordination during landing from a countermovement jump in different gravitational environments to gain insight on how humans perceive gravity and coordinate complex motor tasks. Eight participants performed countermovement jumps on Earth and while submitted to four simulated gravity levels (from 0.2 to 1 g) generated by a downward pull-down force in weightlessness induced by parabolic flights.”
13. Zhang X, Zhu H, Zhang J.Oxidative stress on the ground and in the microgravity environment: Pathophysiological effects and treatment.Antioxidants (Basel). 2025 Feb 18;14(2): 231. Review.Note: This article may be obtained online without charge.
14. Allen GR, Mills WD, Garcia DM.Risk vs. benefit analysis of ultraviolet-C advanced aircraft disinfection.Aerosp Med Hum Perform. 2025 Mar 1;96(3S):A1-A32. Review.Note: From the abstract: “This work provides details and references that help to quantify the benefits of using ultraviolet-C (UV-C) light for air disinfection in aircraft vs. the risk of overexposure to UV-C for passengers and crew.”
15. de Thierry de Faletans C, Misericordia M, Vallier J-M, Duché P, Watelain E.Seasickness simulator to assess anti-motion sickness devices.Aerosp Med Hum Perform. 2025 Mar 1;96(3):212-8.
16. Garbino A, Nusbaum D, Goughnour S, Dalal S, Carminati M-VG, Clark J.Rodent model for high altitude and ebullism exposure studies.Aerosp Med Hum Perform. 2025 Mar 1;96(3):198-205.
17. Li B, Xu Y, Wang D, Wei B, Zhu H, Wu M, Lan X, Yin Q, Cao Y.High-altitude acute hypoxia endurance and comprehensive lung function in pilots.Aerosp Med Hum Perform. 2025 Mar 1;96(3):191-7.
18. Marchant A, Witchalls J, Wallwork SB, Ball N, Waddington G.The effect of combined compression and tactile stimulation on ankle somatosensation in a lunar gravity lower limb load analog.Front Physiol. 2025 Feb 26;16:1537889.Note: From the abstract: “Ankle somatosensation appears to be negatively affected when in simulated hypogravity (gravity, 1 > g < 0). Developing countermeasures to reduce this negative effect is necessary for sensorimotor control as astronauts prepare to explore the Moon.” This article may be obtained online without charge.
19. Muralt L, Lichtblau M, Aeschbacher SS, Bisang M, von Gruenigen K, Sooronbaev TM, Ulrich S, Bloch KE, Furian M.Respiratory acclimatization and psychomotor performance after rapid ascent and during 3 weeks at 3,100 m–A prospective cohort study in healthy individuals.Front Physiol. 2025 Mar 2;16:1530426.Note: This article may be obtained online without charge.
20. Primachenko GK, Shpakov AV, Voronov AV, Sokolov NN.Jump tests after support unloading of various durations: Maximum height and accuracy of performance.Hum Physiol. 2025 Feb 27;50(6):576-83.
21. Zhang Y, Wang T, Wang Z, Shi X, Jin J.Functions and therapeutic potentials of long noncoding RNA in skeletal muscle atrophy and dystrophy.J Cachexia Sarcopenia Muscle. 2025 Apr;16(2):e13747. Review.Note: This article may be obtained online without charge.
22. Wang Y, Li Z, Su R, Wang X, Gao S, Wang Y, Zhang Y, Su Y.Effects of exercise intervention on executive function in 90-day head-down bedrest.Acta Astronaut. 2025 Jul;232:23-31.
23. Putthanbut N, Su PAB, Lee JY, Borlongan CV.Circadian rhythms in stem cells and their therapeutic potential.Stem Cell Res Ther. 2025 Feb 23;16:85. Review.Note: This article may be obtained online without charge.
24. Kallweit L, Hamlett ED, Saternos H, Gilmore A, Granholm A-C, Horowitz S.Chronic RNA G-quadruplex accumulation in aging and Alzheimer’s disease.eLife. 2025 Feb 24;14:RP105446.Note: This article may be obtained online without charge.
25. Zhang L.China’s Space Station and international law-making.Acta Astronaut. 2025 Jul;232:32-8.

astrobiology, space biology, space medicine, microgravity, space station,