NASA Spaceline Current Awareness List #1,163 22 August 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Lungeanu A, DeChurch L, Chan M, Contractor N.Leading the crew to Mars: Evidence from NASA HERA analog crews.Acta Astronaut. 2025 Aug 16. Online ahead of print.PI: L. DeChurchNote: From the abstract: “In order to understand the role of leadership networks in deep space exploration, this study investigated crew leadership in 13 crews participating in HERA campaigns between 2016 and 2020.”
   
   Journal Impact Factor: 3.4
   
   Funding: “This work was supported by the National Aeronautics and Space Administration under awards No. 80NSSC18K0221, 80NSSC18K0276, NNX15AM32G, and 80NSSC21K0925.”
2. Rogers K, Yoon G, Vincenty CS, Trappe S, Trappe TA.Muscle-specific atrophy of the lower limb musculature in response to simulated microgravity exposure in women.J Appl Physiol (1985). 2025 Aug 19. Online ahead of print.PI: S. TrappeNote: Head-down tilt bedrest study. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.3
   
   Funding: “Supported by NASA (NNJ04HF72G, S. and T. Trappe).”
3. Velichala SR, Kim J, Hargens AR.Increasing seated reaction forces with lower body negative pressure.npj Microgravity. 2025 Aug 14;11:56.PI: A.R. HargensNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This study was supported by National Aeronautics and Space Administration Grants NNX14AP25G and 80NSSC19K0409.”
4. Marshall Porterfield D, Tulodziecki D, Wheeler R, Davis Cross MK, Monje O, Rothschild LJ, Barker RJ, Schwertz H, Collicott S, Dutta S.Critical investments in bioregenerative life support systems for bioastronautics and sustainable lunar exploration.npj Microgravity. 2025 Aug 16;11:57. Review.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: R. Wheeler and O. Monje are affiliated with NASA Kennedy Space Center. L.J. Rothschild is affiliated with NASA Ames Research Center.
5. Fargher HA, Lim J, Shuluk JR, Wight CD, Asche S, Devireddy P, Zhou Y, Vera MS, Dahlhauser SD, Bhadra S, Maggiori C, Johnson SS, Graham HV, Ellington AD, Anslyn EV.A compositionally biased oligourethane sensor array to differentiate solids by their surface chemistry: An analogy to the sense of touch.J Am Chem Soc. 2025 Aug 12. Online ahead of print.Note: From the abstract: “Array-based differential sensing is inspired by a mammal’s sense of taste and smell. The human sense of touch is also array-based; using mechanosensors in the skin that differentiate surfaces by their surface chemistry. Inspired by this, we aimed to develop a rationally biased and randomized oligomer sensor array which differentiates bulk solids by their surface chemistry.”
   
   Journal Impact Factor: 15.6
   
   Funding: S. Asche and H.V. Graham are affiliated with NASA Goddard Space Flight Center.

Other papers of interest:

1. Kanatsu-Shinohara M, Yamamoto T, Shiromoto Y, Morimoto H, Liu T, Yamamori T, Yamasaki T, Shinohara T.Germline transmission of cryopreserved mouse spermatogonial stem cells maintained on the International Space Station.Stem Cell Rep. 2025 Aug 14;102602. Online ahead of print.Note: ISS results. This article may be obtained online without charge.
2. Denda M.Epidermal homeostasis in space from the stand point of keratinocyte physiology.Skin Pharmacol Physiol. 2025 Aug 15;1-11. Review.Note: This article may be obtained online without charge.
3. Fomina E, Burakova A, Senatorova N.Dynamics of functional reserves of cosmonauts in a long space flight according to the results of the “Individual Strategies” test.Acta Astronaut. 2025 Nov;236:1249-56.
4. Young ME, Khanna V, Metcalfe M, Rameshkumar N, Harington S, Li LH, Doost JS, Taegtmeyer H, Martino TA.A brief history of circadian time in the heart.J Mol Cell Cardiol. 2025 Aug 19. Review. Online ahead of print.Note: This article may be obtained online without charge.
5. de Vita C, Imparato C, Ambrosino F, Verde GL, Sovilj MP, Pugliese M.Radiation risk models for Mars exploration.2025 IEEE 12th International Workshop on Metrology for AeroSpace (MetroAeroSpace). 2025 Jun;18-20.Note: This article is a conference proceeding published in peer-reviewed journal MetroAeroSpace and may be obtained online without charge.
6. Guha A, Harish S, Sendhilvel V, Ramasubramoniam S, Siva M.Insights into the effect of microgravity on phytopathogens and plant-associated microbes.Life Sci Space Res. 2025 Aug 16. Review. Online ahead of print.
7. Huang X, Li Z, Wang Q, Liu J, Zhang G, Chen R, Bu X, Wang Y, Luo P, Zhang L, Hajdu A.Space dentistry combined with remote and AI technologies, a necessity for long-term stays: Thoughts of US astronauts’ unexpected stay.Oral Dis. 2025 Aug 16. Online ahead of print.
8. Lin K, Ma J, Ji X, Xu K, Zhang L, Huang Y.Impact of microgravity on space microbes and application prospects.Acta Astronaut. 2025 Nov;236:1115-29.
9. Schafer BC, Kim JH, Sharipov F, Hwang GS, Vlassak JJ, Keith DW.Photophoretic flight of perforated structures in near-space conditions.Nature. 2025 Aug 13;644(8076):362-9.Note: From the abstract: “Lightweight nanofabricated structures could photophoretically loft payloads in near-space. Proposed structures range from microscale engineered aerosols, to centimeter-scale thin disks with variations in surface accommodation coefficients, to sandwich structures with nanoscale thickness that might be extended to meter-scale width. Quantitative understanding of how structural and surface properties determine photophoretic lofting forces is necessary to develop a practical flying device. Here, we focus on thermal transpiration as the most promising photophoretic mechanism for lofting large devices and present a hybrid analytical-numerical model of the lofting force on a structure that consists of two perforated membranes spaced a small distance apart.”
10. Xie J, Ma C, Wei Y, Luo J, Men Y, Wang L, Xiong Y, Zheng W, Lei X.3D culture and cryopreservation/thawing strategy of human induced pluripotent stem cells for spaceflight experiments.Life Sci Space Res. 2025 Aug 15. Online ahead of print.
11. Rangdal A, Munoz S, Ma C, Lorenzo MSD, Sherman LS.Advancing science in microgravity – Implications for effective therapies.Int J Transl Sci. 2025 Jul 30;2025(01);1-16.
12. Fisher JT, Mekjavic IB, Ciuha U.Implications of sex differences in orthostatic tolerance during exposure to acute artificial gravity.npj Microgravity. 2025 Aug 12;11:55.Note: This article may be obtained online without charge.
13. Liu JS, Yan NQ, Mao YY, Xin C, Mou DP, Gao XX, Guo J, Wang NL, Zhu SQ.Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats.Int J Ophthalmol. 2025 Aug 18;18(8):1409-25.Note: This article may be obtained online without charge.
14. Patel M, Naphade A, Mehta P.Space pharmaceutical manufacturing: Emergence of a new era for pharmaceutical industry.Drug Dev Res. 2025 Sep;86(6):e70145. Review.
15. Ryu D, Kim D, Shim Y, Jin G, Mun S, Kim J, Yoon HS, Cho SK, Kim H, Choi JS, Yoo HJ, Bang S, Yang SG.Cellular changes in an in vitro neural circuit system under simulated microgravity.Acta Biomater. 2025 Aug 12. Online ahead of print.Note: A rotating clinostat was used in this study to simulate microgravity.
16. Zaccaria T, Bulut Ö, Ferreira AV, Dona M, Langereis JD, Mesman RJ, Wesseling J, van Niftrik L, Netea MG, Rettberg P, Beblo-Vranesevic K, de Jonge MI, Domínguez-Andrés J.Effects of simulated Martian environmental stressors on specific human pathogen-immune system interactions.mBio. 2025 Aug 18;e0109925. Online ahead of print.Note: This article may be obtained online without charge.
17. Ding Y, Tong F, Liu M, Yang P, Zeng J, Wei Y, Li C, Li D, Chang C, Zhang Y, Yi S, Hu F, Shu W, Zhang L, Cui CP.Integrative omics reveals glutamine catabolism-driven apoptotic suppression in monocytes upon mechanical unloading.Adv Sci (Weinh). 2025 Aug 18;e00585. Online ahead of print.Note: This article may be obtained online without charge.
18. Gu W, Liu D, Wei L, Yang Z, Jiang S, Dai S, Cao T, Shen Z.Administration of β-nicotinamide mononucleotide attenuates myocardial dysfunction in hindlimb unloading in mice.J Cardiovasc Pharmacol Ther. 2025 Aug 17;30:10742484251369609. Online ahead of print.Note: This article may be obtained online without charge.
19. Qiu M, Liao Z, Wu X, He P, Wen X, Xie Y, Qi J.ALKBH5-mediated m6 a demethylation modification of RAD51 inhibits osteogenic differentiation via promoting DNA damage in osteoporosis.Mol Immunol. 2025 Aug 16;186:82-94.
20. Aldiss Z, Lam Y, Robinson H, Dixon R, Steinhardt L, Crisp P, Godwin I, Borrell A, Hickey L, Massel KThe PIN2 ortholog in barley modifies root gravitropism and architecture.The Plant Genome. 2025 Aug 6;18(3):e70061.Note: This article may be obtained online without charge.

Astrobiology, space biology, space life science, space medicine, Microgravity, ISS,