NASA Spaceline Current Awareness List #1,197 24 April 2026 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Monfared V, Iwaniec UT, Turner RT.Spaceflight and the rodent skeleton: A perspective.Bone Reports. 2026 Apr 13;101917.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.6
   
   Funding: “This work was supported by the Center for Commercial Development of Space and NASA grant 80NSSC24K0579.”
2. Chander AM, Burr DJ, Wipf S, Nitsche R, Fujimura G, Schubert W, Singh NK, Bell JJ, Brandl A, Weil MM, Elsaesser A, Venkateswaran K.Survival of NASA-Cleanroom microbial isolates under simulated space and Martian conditions.Appl Environ Microbiol. 2026 Apr 20;e0206525. Online ahead of print.PI: M.M. WeilNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.7
   
   Funding: “Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). We acknowledge NASA grants 80NSSC23K1298 and NNX15AK13G, which cover the neutron facility at Colorado State University at Fort Collins. …The research described in this manuscript was funded by the NNH18ZDA001N-PPR award 18-PPR18-0011 to K.V. …”
3. Keller N, Thoolen S, Siders B, Estep P, Scully R, Levine BD, Babb T, Pawelczyk J, Baughman A, Basner M, Young M, Chappell L, Norcross J, Marshall-Goebel K, Garbino A.Effects of carbon dioxide on physical and cognitive performance in a simulated spacesuit contingency scenario.npj Microgravity. 2026 Apr 21.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “The current study was made possible by an exemplary science team at NASA Johnson Space Center and would not have been accomplished without the tremendous support of Kadambari Suri, Jazmyne Lones – Humphrey, Benjamin Estep, Amanda Hager, Shayne York, Caleb Cram, Paul Smith, and Meghan Anderman. Data processing and visualization was accomplished with the help of Kyoung Jae “KJ” Kim. The study was originally proposed and developed by Derek Nusbaum, MD, PhD, MPH, and funded as a directed study by the Human Health and Countermeasures element of NASA’s Human Research Program.”
4. Naitchede LHS, Ihearahu OC, Saha K, Igwe DO, Yan J, Osano AA, Ray S, Ude G.Microbial community characterization in semi-hydroponic systems of Starbor kale (Brassica oleracea L.) grown under normal gravity and simulated microgravity.Curr Res Microb Sci. 2026;10:100592.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.8
   
   Funding: “This research was funded in its entirety by NASA (National Aeronautics and Space Administration), USA, under grant number 80NSSC22K0869, and by the Department of Education Title III Part B HBCU (Course-Based Undergraduate Research Experiences Program at Bowie State University), grant number GR23000897.”
5. Lopez JM, Hirsa AH.Effects of nonlinearity on the interplay between monolayer elasticity, surface viscosities and surface diffusivity.Eur Phys J Spec Top. 2026 Apr 11. Online ahead of print.PI: A.H. HirsaJournal Impact Factor: 2.3
   
   Funding: “This work was supported by National Science Foundation Grant Nos. 2204081, 2204082 and 2323020 and NASA grant 80NSSC25K7630.”

Other papers of interest:

1. Moriggi M, Capitanio D, Torretta E, Metatla I, Frings-Meuthen P, Heinz V, Trautmann G, Salanova M, Blottner D, Gelfi C.Proteograph™-based proteome and sphingolipidome analyses identified novel serum biomarkers to monitor astronauts’ health in spaceflight.Front Physiol. 2026 Apr 21;17:1773221.Note: ISS results.This article may be obtained online without charge.
2. Trivedi R, Prajapati C.Microgravity-induced alterations in human physiology and cellular homeostasis during long-duration spaceflight.Exon. 2026 Apr 14;3(2):94-116.Note: From the abstract: “Astronaut’s health is at risk when they spend a long time in space because being in microgravity for a long time can throw off their physiological systems and cellular homeostasis. This manuscript synthesizes current research on the systemic and cellular impacts of microgravity, focusing on its effects on the immune, cardiovascular, gastrointestinal, nervous, musculoskeletal, and bone remodeling systems. We also look at how microgravity affects cells, causing stress responses like dysregulated autophagy, oxidative damage, and apoptosis. These processes all lead to tissue degeneration and a loss of function. A close look at ground-based simulations (like clinostats and hindlimb unloading) and in-orbit experiments on the International Space Station (ISS) shows how these models help us learn about how cells change and don’t change, like how immune cells work, how blood vessels work, and how stem cells become different types of cells.” This article may be obtained online without charge.
3. Dino MJ, Villafuerte CM, Pimentel J, Sayat J, Vital JC, Hernandez D, Thiamwong L, Decker V, Shattell M, Cruz LE, Leoncio M, Reyes JR, David R, Manalili JA.Aerospace health: A systematic review and current state of science.Front Space Technol. 2026 Jan 28;7:1736627.Note: This article may be obtained online without charge.
4. Khan H.Interstellar informatics: Visualizing space medicine through artificial intelligence.In: Malawana J, Arjomandi Rad A, Vardanyan R, Miller G, eds. Artificial Intelligence in Healthcare and Biomedical Visualization. Cham, Switzerland: Springer Nature, 2026. p. 123-55.
5. Khan SUE, Varghese RJ, Kassanos P, Farina D, Burdet E.Space physiology and technology: Adaptations, countermeasures, and opportunities for wearable systems.Cyborg Bionic Syst. 2026 Apr 17;7:0477. Review.Note: This article may be obtained online without charge.
6. Kijak K, Lubkowska A, Skomro P, Ardan R, Budkowska M, Gronwald B, Gronwald H, Stachowska E, Kijak K, Orzechowski L, Mintus A, Lietz-Kijak D.Analytical comparison of physiological parameters in participants during an analog space mission.Front Space Technol. 2026 Apr 9;7:1752453.Note: This article may be obtained online without charge.
7. Minoretti P.Integrating space sexology into long-duration mission architecture: A five-pillar operational framework.Cureus. 2026 Mar 12;18(3):e105103. Review.Note: From the abstract: “The imminent transition from low Earth orbit operations to sustained deep-space exploration introduces significant demands upon crew health systems that extend well beyond the physiological and psychological domains traditionally addressed in aerospace medicine. Despite growing recognition that sexuality and reproductive health represent fundamental dimensions of human well-being, these domains have remained conspicuously absent from official mission planning, crew training curricula, and habitat design specifications. This narrative review was therefore undertaken to appraise and synthesize existing evidence on the biological, psychological, ethical, and technological dimensions of human sexuality relevant to long-duration spaceflight and to identify critical knowledge gaps and operational vulnerabilities.” This article may be obtained online without charge.
8. Nwankwo OG, Pelton JN.Protective magnetic shielding systems for deep space habitats: Safeguarding humans and infrastructure from space weather hazards.Front Space Technol. 2026 Mar 19;7:1715603.Note: This article may be obtained online without charge.
9. Opsomer L, Vandergooten S, Thonnard JL, McIntyre J, Lefèvre P.Effect of risks, consequences, and gravitational priors on sensorimotor coordination: Insights from weightlessness.J Neurosci. 2026 Apr 20. Online ahead of print.Note: When manipulating objects, our brain continuously adjusts grip force (GF) to the variations in load force (LF) generated by our own movements. GF-LF coordination provides a window into the predictive capabilities of the brain. To better understand how gravity influences these predictions, we analyzed grip dynamics and movement kinematics in astronauts (2 females, 9 males) manipulating objects on the ground (in 1G) and during spaceflight in a stable weightless environment (in 0G).”
10. Parkarwar N, Dabhekar S, Dwivedi V, Taksande B, Umekar M, Mangrulkar S.Decoupling musculoskeletal integrity in microgravity: Molecular drivers and therapeutic horizons.Life Sci Space Res. 2026 Apr 19. Review. Online ahead of print.
11. Zivi P, Sdoia S, Ventura R, Ferravante D, Ferlazzo F.Challenges for cognitive research in spaceflight and analog environments.iScience. 2026 .Note: This article may be obtained online without charge.
12. Bettadapura SS, Tangeman DC, Satyanarayana SB, Ruhmann MM, Bonds WJ, Edwards JH, Gupta P, Yusifov A, Todd WD, Bruns DR.The cardiac circadian clock regulates rhythms in peripheral tissues via fibulin 5.Compr Physiol. 2026 Apr;16(2):e70147.Note: This article may be obtained online without charge.
13. Shea SA, Scheer FAJL, Gumz ML, Eikenberry SA, Qian J, Thosar SS, Sole MJ, Martino TA.Unlocking the potential of circadian biology for cardiovascular health.Physiological Reviews. 2026;106(3):1195-262.Note: This article may be obtained online without charge.
14. Du W, Peng XY, Li W, Attiq UR, Ge MW, Shen LT, Feng R, Zhong K, Gao SQ, Chen HLEthnopharmacology, pharmacokinetics, and antitumor potential of Resina Draconis (Dragon’s Blood): A systematic review connecting traditional use to molecular mechanisms.J Ethnopharmacol. 2026 Apr 16;121702. Review.
15. Malone L, Cardin M-A, Cilliers J, Starr S, Hadler K.Controlled user study on the role of situational awareness in design decisions for future lunar in-situ resource utilization systems.Acta Astronaut. 2026 Apr. 19. Online ahead of print.Note: From the abstract: “As human exploration of the Moon and Mars transitions from temporary missions to long-term habitation, in-situ resource utilization (ISRU) is expected to play a pivotal role in enabling future sustainable economic and scientific activities in space. Designing and operating ISRU systems under such extreme and uncertain conditions, however, presents major challenges, ranging from dealing with harsh environmental conditions, regulatory complexity, to differing stakeholder risk tolerance profiles and unpredictable technological system behavior. This study introduces a novel experimental methodology to investigate how human factors playing an important role in situational awareness can influence ISRU-related design decision-making and associated performance under uncertainty.” This article may be obtained online without charge.
16. Miller RC, Kang S, Wang J, Huang K-Y, Lee J, Kim YJ, Han H-S, Kong H.Shear-induced CROSS (Cellular RedOx Spreading Shield) assembly sustains neurotrophic extracellular vesicle production for functional neural networks.Adv Funct Mater. 2026;36(27):e22252.Note: This article may be obtained online without charge.
17. Schmidt S, Fisk ID, Yang N, Saarela M, Hessel V.Formulation of personalized, fortified beverage nanoemulsions for space exploration with omega 3 polyunsaturated fatty acids.ACS Food Sci Technol. 2026 Apr 17;6(4):1092-111.Note: This article may be obtained online without charge.
18. Xue H, Zeng D, You Y, Zhang J, Chen X, Xing Q, Zeng W, Wu M, Pan J, Zhu Y.Circadian disruption exacerbates MASH by reducing Akkermansia muciniphila via the FXR-CYP7A1-bile acid axis.iScience. 2026 Apr 17;29(4):115397.Note: This article may be obtained online without charge.
19. Yu F, Ma X, Liu Y, Wang R, Wang Y, Qiao P-G, Zheng W, Hu X, Qian L, Ren P, Wang Z.Renal macrostructural and hilar Doppler hemodynamic stability during a 7-day head-down tilt bedrest: An exploratory ultrasound-based study in humans under simulated microgravity.Life Sci Space Res. 2026 Apr 23. Online ahead of print.

Astrobiology, space life science, space biology, microgravity, genomics, space biomedicine, gravitational biology,