NASA Spaceline Current Awareness List #1,152 6 June 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Lonner TL, Allred AR, Gopinath AR, Morgheim T, Groen EL, Oman CM, DiZio P, Lawson BD, Drecksler SR, Clark TK.Reducing motion sickness during simulated astronaut post-spaceflight water landings using anticipatory cues or postural control.npj Microgravity. 2025 Jun 2;11:21.PI: T.K. ClarkNote: From the abstract: “To assess the efficacy of the selected countermeasures in reducing the incidence and severity of motion sickness in astronauts following a water landing, we utilized a series of ground-based analogs for the gravity transition and sea state motion astronauts experience. Protocols and motion devices were identical to those we have used previously in Lonner et al. Gravity transitions were simulated on the Human Eccentric Rotator Device (HERD) centrifuge using the Sickness Induced by Centrifugation (SIC) paradigm: exposing subjects to a net 2Gx gravito-inertial force for approximately one hour to generate a vestibular disturbance upon return to Earth gravity.” This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by the National Aeronautics and Space Administration Human Research Program under Grant No. 80NSSC21K0257.Additionally, this work was supported by a NASA Space Technology Graduate Research Opportunities Award.”
2. Vimal VP, DiZio P, Lackner JR.The effect of vibrotactile feedback on performance, perception, and trust when balancing in different analog g-levels.Exp Brain Res. 2025 May 31;243:161.PI: V.P. VimalNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 1.7
   
   Funding: “VPV was supported by NASA’s Human Research Program under grant 80NSSC22K0758 and NAMRU N0018923P0725.”
3. Bimal A, Beres SL, Rodrigues VR, Smith BK, Davenport PW, Napoli NJ.Leveraging intrinsic non-sinusoidal patterns to infer search behavior to predict exposure to respiratory stressors.Am J Physiol Lung Cell Mol Physiol. 2025 May 27. Online ahead of print.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.6
   
   Funding: “The authors thank NASA Langley Research Center and NASA System-Wide Safety Project for support as the funding agency for this work and San Jose State University Research Foundation (Agreement number: 80NSSC22M0060) for support of this work. We also thank the Office of Naval Research (grant number N00014-22-1- 2653) for support in the development of these respiratory algorithms.”
4. Slaba TC, Poignant F, Rahmanian S.A microdosimetric dose response model for monoenergetic ions and doses relevant for space radiation carcinogenesis.Radiat Res. 2025 Jun 6. Online ahead of print.Note: From the abstract: “This work focuses on developing a microdosimetric (D) dose-response model applicable to experimental datasets relevant to space radiation cancer induction. Three experimental datasets, encompassing murine Harderian gland tumorigenesis and chromosome aberrations in human skin fibroblasts and blood lymphocytes, are utilized to demonstrate key features and overall performance of the D model. The model generates non-linear dose-responses and can predict charge and energy dependence observed in experimental data without the use of empirical functions or corrections. Additionally, the D model identifies the critical microscopic target population and target size that drive the observed biological effects.”
   
   Journal Impact Factor: 1.4
   
   Funding: T.C. Slaba is affiliated with NASA Langley Research Center.
5. McClure R, Rivas-Ubach A, Hixson KK, Farris Y, Garcia M, Danczak R, Davison M, Paurus VL, Jansson JK.Multi-omics of a model bacterial consortium deciphers details of chitin decomposition in soil.mBio. 2025 May 30. Online ahead of print.PI: R. McClure, J.K. JanssonNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by the NASA Dynamics of Microbiomes in Space (DynaMoS) project.”
6. Wu F, Mu WC, Markov NT, Fuentealba M, Halaweh H, Senchyna F, Manwaring-Mueller MN, Winer DA, Furman D.Immunological biomarkers of aging.J Immunol. 2025 May 30;214(5):889-902. Review.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 3.6
   
   Funding: “This work was funded, in part, through funds derived from National Institutes of Health grant R01DK128435 (D.A.W.); Canadian Institutes of Health Research grant PJT-186165 (D.A.W.); the Buck Institute for Research on Aging Bioinformatics and Data Science Core (F.W., W.-C.M, N.T. M., M.F., H.H., F.S., M.N.M.-M., D.F.); National Institute of Neurological Disorders and Stroke grant 2R01NS100529- 06A1 (D.F.); National Aeronautics and Space Administration grant NNX16AE78G AM 000012 (D.F.); National Institute on Aging grants 5P01AI153559-03 (W.-C.M., D.F.), 5P01AG066591-02 (N.M., F.S., D.F.), 5U54AG075932-02 (F.W., F.S., D.F.), 5P01 AG066591-03S1 (N.M., D.F.), 1U01AG086214-01 (M.F., D.F.), P01AG066591 (N.T.M, D. F.), and T32AG000266 (N.T.M); and National Institutes of Health Office of the Director grant 1R03OD036497-01 (M.F., D.F.).”

Other papers of interest:

1. Asrar FM.How to keep astronauts healthy in deep space.Nature. 2025 Jun 2;642(8066):31-3.Note: This article is a Comment.
2. Fall L, Bailey DM.Houston, we have a problem: Coagulation concerns during long-term spaceflight.Exp Physiol. 2025 May 31. Online ahead of print.Note: This article is an Editorial and may be obtained online without charge.
3. Huo R, Xu S, Chen X.Directional astronaut radiation dose for hemispherical galactic cosmic ray irradiation.Life Sci Space Res. 2025 May 31. Online ahead of print.Note: From the abstract: “Radiation exposure constitutes a critical challenge for current and prospective space exploration programs, particularly crewed missions where sustained radiation levels pose substantial health risks to crew members. The space radiation environment comprises multiple ionizing radiation sources. This study specifically addresses galactic cosmic rays (GCRs), as the highest-energy cosmic ray component and one that poses the greatest shielding challenges due to its penetration capacity.”
4. Pulvirenti E, Diteesawat RS, Stinchcombe A, Hauser H, Rossiter J.Advancing space health: Towards a soft wearable hypogravity exosuit for enhanced mobility in Martian conditions.Acta Astronaut. 2025 Oct;235:83-9.
5. Rodrigues GA, Russomano T, Santos Oliveira E.Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): A systematic review.npj Microgravity. 2025 Jun 2;11:22.Note: This article may be obtained online without charge.
6. Bakri A, Ismail A, Mansour A, Struillou X, Talaat IM, Elmoselhi AB, Badran Z.Microgravity exacerbates periodontitis in vivo.J Periodontal Res. 2025 May 31. Online ahead of print.
7. Chen Z, Xie J, Ma C, Zhang P, Lei X.Oxidative damage under microgravity conditions: Response mechanisms, monitoring methods and countermeasures on somatic and germ cells.Int J Mol Sci. 2025 May 10;26(10):4583. Review.Note: This article is part is Special Issue “Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress” (https://www.mdpi.com/journal/ijms/special_issues/6969Q0OCS2). The Special Issue also includes an article from previous Current Awareness List #1,137 https://doi.org/10.3390/ijms26031287. This article may be obtained online without charge.
8. Bradfield DT, Slaven JE, Rittase WB, Rusnak M, Symes AJ, Brehm GV, Muir JM, Lee SH, Anderson JA, Day RM.Cell death and iron deposition in the liver in two murine models of acute radiation syndrome.PLoS One. 2025 May 29;20(5):e0324361.Note: This article may be obtained online without charge.
9. Cooper H, Lau HM, Mohan H.A systematic review of ergonomic and muscular strain in surgeons comparing robotic to laparoscopic approaches.J Robot Surg. 2025 May 31;19:252. Review.Note: This article may be obtained online without charge.
10. Gilworth RE, Skinner BD, Hodgkiss DD, Lucas SJE, Lucas RAI.Mapping the evidence on the impact of heat stress on exercise and work performance in females: A scoping review.Front Physiol. 2025 Jun 2;16:1507398.Note: This article is part of Research Topic “Acute and Chronic Responses to Heat Stress to Optimize Health and Performance” (https://www.frontiersin.org/research-topics/61190/acute-and-chronic-responses-to-heat-stress-to-optimize-health-and-performance/overview). The Research Topic also includes an article from previous Current Awareness List #1,089 https://doi.org/10.3389/fphys.2024.1356488. This article may be obtained online without charge.
11. Kim YM, Sanborn MA, Vijeth S, Gajwani P, Wang X, Jung D, Valyi-Nagy T, Chakraborty S, Mancinelli G, Toth PT, Phillips EH, Grippo P, Salahudeen AA, Park J, Yeon SY, Ananthanarayanan V, Jiang Y, Lee SS, Valyi-Nagy K, Rehman J.Skeletal muscle endothelial dysfunction through the activin A-PGC1α axis drives progression of cancer cachexia.Nat Cancer. 2025 May 26.Note: This article may be obtained online without charge.
12. O’Connor L, Minogue E, Carolan S, Darcy G, Chueiri A, Faherty M, Morton J, Mc Donagh F, Singh NK, Venkateswaran K, Miliotis G, Smith TJ.Rapid detection of the novel human pathogen Pantoea piersonii: Advancements in methodology.Diagn Microbiol Infect Dis. 2025 May 20;113(2):116905.Note: From the abstract: “Pantoea piersonii a novel bacterium isolated from the International Space Station (ISS) presents a unique challenge for microbial monitoring in spaceflight and more recently in clinical environments. Identification of the organism currently involves culture, followed by whole genome sequencing and analysis of generated sequences. Since the MALDI-TOF profile of this pathogen is absent from the database and 16S rRNA sequencing fails to resolve its identity to the nearest neighbor, a definitive genetic marker is required for unambiguous identification of the organism. Given the increase in the number of reported clinical cases, there exists a need for a rapid method for identification of the organism which could be utilized in a range of environments including the clinical setting.”
13. Bogotskoy KA, Tarasova OS, Panchin Y.Pannexin 1 increases mouse cerebral blood flow response to hypercapnia but not to skin receptor stimulation.Aviakosm Ekolog Med. 2025;59(2):40-5. Russian.
14. Ilyin VK, Rykova MP, Solovieva ZO, Sadchikova ER, Nosovsky AM, Lovtsevich SM, Tkacheva EO, Krivonogov IA, Skedina MA.Investigation of the effect of prophylactic lactoferrin rinse on the parodontium of participants in a 5-day dry immersion study.Aviakosm Ekolog Med. 2025;59(2):20-6. Russian.
15. Kiriy AR, Shef KA, Aleksandrova AV, Antonov EA, Kovbasiuk IE, Zaripov IE, Poddubko SV.Sanitary-microbiological monitoring of the environment in the SIRIUS-23 isolation study.Aviakosm Ekolog Med. 2025;59(2):12-9. Russian.
16. Kravtsova EN, Meigal A, Kulgova ED, Gerasimova-Meigal L, Dvorianchikov VV.Effect of the bone conduction sound on the vertical standing of people with bilateral vestibular hypofunction in complex sensory conditions.Aviakosm Ekolog Med. 2025;59(2):54-60. Russian.
17. Markina EA, Bobyleva PI, Barantseva M, Buravkova LB.Effect of 14-day unloading and re-adaptation on hematopoietic precursors from the distal and proximal parts of rat’s hindlimbs.Aviakosm Ekolog Med. 2025;59(2):33-9. Russian.
18. Orlova KD, Shmarov VA, Zhirova EA, Shulguina SM, Vlasova DD, Kotikova AA, Ponomarev SA.The effect of dry immersion on latent sensitization to food-borne and inhaled allergens.Aviakosm Ekolog Med. 2025;59(2):5-11. Russian.
19. Sharlo KA, Tyganov SA, Sidorenko DA, Bokov RO, Zaripova KA, Nemirovskaya TL.Inhibition of DHPR prevents decline of m. soleus strength in rats during 3-day functional unloading.Aviakosm Ekolog Med. 2025;59(2):27-32. Russian.
20. Yasnetsov V, Ivanov Y, Karsanova SR, Yasnetsov VV.Anti-motion sickness effect of new heterocyclic compounds LKHT 1-22 and LKHT 4-22.Aviakosm Ekolog Med. 2025;59(2):61-4. Russian.
21. Veeraperumal S, Gawali B, Singh N, Sevim-Wunderlich S, Czajkowski MT, Munjal Mehta S, Asang C, Pleimes D, Pawar SA.Imidazolyl ethanamide pentandioic acid promotes hematopoietic recovery following sublethal radiation in a murine model.Int J Radiat Biol. 2025 May 27;1-17. Online ahead of print.
22. Shang Y, Huang Y, Li L, Wu F, Chen R.Electrochemical energy storage toward extreme conditions: Driving human exploration beyond current boundaries.Chem Rev. 2025 May 30. Review. Online ahead of print.Note: From the abstract: “Major projects reliant on electric energy support, such as crewed spaceflight, ocean exploration, and polar development, will encounter extreme environmental challenges. The most representative scenarios, including deep space, deep sea, deep Earth, and polar regions, will be systematically discussed in this review.”

Astrobiology, space biology, space life science, space medicine, Microgravity, ISS,