NASA Spaceline Current Awareness List #1,149 16 May 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Lim S, Veres JE, Almeida EAC, O’Connell GD.Characterization of the murine spine for spaceflight studies.PLoS One. 2025 May 13;20(5):e0301316.Note: ISS results. This article may be obtained online without charge.
   
   Journal Impact Factor: Not available for this journal
   
   Funding: “This study was funded by the National Science Foundation (1751212, GDO) and the National Aeronautics and Space Administration (NNH14ZTT001N 14-14SF Step2-0063, EACA).”
2. Ong J, Mader T, Gibson CR, Suh A, Panzo N, Memon H, Lee R, Soares B, Waisberg E, Sampige R, Nguyen T, Kadipasaoglu C, Guo Y, Vineyard K, Masalkhi M, Osteicoechea D, Vizzeri G, Chévez-Barrios P, Berdahl J, Barker DC, Schmitt HH, Lee AG.The ocular surface during spaceflight: Post-mission symptom report, extraterrestrial risks, and in-flight therapeutics.Life Sci Space Res. 2025 May 9. Review. Online ahead of print.Journal Impact Factor: 2.9
   
   Funding: C.R. Gibson is affiliated with NASA Johnson Space Center.
3. Whittle RS, Keller N, Hall EA, Patanam S, Dunbar BJ, Diaz-Artiles A.Integrative cardiovascular dose-response to graded lower-body negative pressure.Exp Physiol. 2025 May 14. Online ahead of print.PI: A. Diaz-ArtilesNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 2.6
   
   Funding: “National Aeronautics and Space Administration; NASA Human Research Program, Grant/Award Number: 80NSSC20K1521; Sydney and J. L. Huffines Institute for Sports Medicine and Human Performance.”
4. Krishnavajhala A, Gingras M-C, Urquieta E, Chao H, Bandaranaike D, Chen Y, Bhamidipati S, Korchina V, Griffin SM, Masternak MM, Moreno H, Mohammed J, Murugan M, Posey JE, Wu JH, Muzny D, Gibbs RA, Doddapaneni H.The GENESTAR manual for biospecimen collection biobanking and omics data generation from commercial space missions.npj Microgravity. 2025 May 14;11(1):16.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This study was funded (Grant# INN0010) by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A.”
5. Schultz J, Jamil T, Sengupta P, Sivabalan SKM, Rawat A, Patel N, Krishnamurthi S, Alam I, Singh NK, Raman K, Rosado AS, Venkateswaran K.Genomic insights into novel extremotolerant bacteria isolated from the NASA Phoenix mission spacecraft assembly cleanrooms.Microbiome. 2025 May 12;13(1):117.Note: From the abstract: “Human-designed oligotrophic environments, such as cleanrooms, harbor unique microbial communities shaped by selective pressures like temperature, humidity, nutrient availability, cleaning reagents, and radiation. Maintaining the biological cleanliness of NASA’s mission-associated cleanrooms, where spacecraft are assembled and tested, is critical for planetary protection. Even with stringent controls such as regulated airflow, temperature management, and rigorous cleaning, resilient microorganisms can persist in these environments, posing potential risks for space missions.” This article may be obtained online without charge.
   
   Journal Impact Factor: 13.8
   
   Funding: “This work was supported by Prof. Alexandre Soares Rosado’s KAUST Baseline Grant (BAS/1/1096-01-01). Part of the research described in this publication was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. This research was funded by a 2006 NASA Planetary Protection Research ROSES award to KV.”
6. Thoolen SJJ, Watson JM, Fellows AM, Bovard PP, Strangman GE, Buckey JC, Stankovic AS.Virtual reality-based sensory stimulation preferences at Amundsen-Scott South Pole Station in Antarctica.npj Microgravity. 2025 May 11;11(1):15.PI: A.S. StankovicNote: This article may be obtained online without charge.
   
   Journal Impact Factor: 5.1
   
   Funding: “This work was supported by NASA grant 80NSSC20K1852. It also received support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 TR002541) and financial contributions from Harvard University and its affiliated academic healthcare centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of NASA, Harvard Catalyst, Harvard University and its affiliated academic healthcare centers, or the National Institutes of Health. The authors would like to thank biostatistician Dr. Hui Zheng at Massachusetts General Hospital and Harvard Catalyst for statistical consultation, and Eric Fassbender at Atmosphaeres Inc for providing VR video footage. Additionally, we would like to express our gratitude to the Human Factors and Behavioral Performance (HFBP) Element of the NASA Human Research Program (HRP), the NASA Research Operations and Integration team, the NSF, and the US Antarctic Program for their support with the implementation of this study. Finally, we would like to thank the research participants from the 2022 winter-over crew at Amundsen-Scott South Pole Station for their continued interest and motivation in taking part in this study.”
7. Moulod M, Dontha B, Balbaugh S, Li J, Miranda F, Kiourti A, Hoelzle DJ.Highly conductive biomaterial for the safe printing of wireless biosensors and antennas inside the body.ACS Appl Mater Interfaces. 2025 May 9. Online ahead of print.Note: From the abstract: “This paper investigates a conductive biomaterial for a new wireless biosensor fabrication paradigm in which relatively large (order of 2-5 cm) electromagnetic components are printed intracorporeally, meaning inside the body, using minimally invasive robotics.”
   
   Journal Impact Factor: 8.5
   
   Funding: F. Miranda is affliliated with NASA Glenn Research Center.

Other papers of interest:

1. Shafirkin AV, Benguin VV, Shurshakov VA.Comparison with the radiation safety limits of the dose values to critical organs of the human body in long-term missions to orbital stations Mir and ISS.Hum Physiol. 2025 May 12;50(7):767-77.
2. Akgun Y.Transfusion medicine beyond Earth: Preparing for human blood management in space missions.Transfus Clin Biol. 2025 May 6.Note: This article is an editorial.
3. Berseneva AP, Funtova II.Prenosological diagnosis as a method to evaluate the functional states at the boundary between health and disease and its place in space and terrestrial medicine.Hum Physiol. 2025 May 12;50(7):778-90.
4. Larina IM, Pastushkova LK, Goncharova AG, Kashirina DN.Piloted space flight and studies in proteomics.Hum Physiol. 2025 May 12;50(7):722-35. Review.
5. Paladugu P, Kumar R, Sporn K, Ong J, Song A, Sekhar T, Gowda C, Davidoff N, Shin S, Lee AG.Shared mechanisms in neuromyelitis optica spectrum disorder and spaceflight-associated neuro-ocular syndrome: Insights into central nervous system fluid dynamics, glymphatic function, and astrocyte dysregulation.Life Sci Space Res. 2025 May 11. Review. Online ahead of print.
6. Saveko AA, Netreba AI, Shved DM, Shpakov AV, Rozanov IA, Gushin VI, Tomilovskaya ES.Evaluation of the functional capabilities of the crew when performing extravehicular activities after long-term isolation in a ground based model of a space station.Hum Physiol. 2024 May 12;50(7):817-25.
7. Chiarini L, Filosi L, Desiderio A, Villani ME, Proietti S, Moscatello S, Battistelli A, Boscheri G, Marchitelli G, Tabacchioni S.Selection and characterization of bacterial consortia for the degradation of space organic waste.Life Sci Space Res. 2025 May 12. Online ahead of print.Note: From the abstract: “Planned human exploration beyond low Earth orbit involves establishing long-term Moon and Mars settlements. Due to the impracticality of continuous resupply from Earth for such missions, it is crucial to develop systems that allow partial or complete in situ recycling of resources necessary for human survival, such as Bioregenerative Life Support Systems (BLSSs), closed artificial ecosystems providing oxygen, food, and water. Microorganisms can play an important role in BLSSs for space missions by producing oxygen, removing carbon dioxide, and degrading organic waste such as food scraps, inedible plant portions, and human feces. This study aimed to select and identify bacterial communities capable of efficiently degrading organic waste generated during space missions.”
8. Li S, Liu K, Wang H, Yang R, Li X, Sun Y, Zhong R, Wang W, Li Y, Sun Y, Wang G.Pose estimation and tracking dataset for multi-animal behavior analysis on the China Space Station.Sci Data. 2025 May 10;12:766.Note: From the article: “The China Space Station (CSS) is a national-level space laboratory that provides a long-term, stable microgravity environment, making it an essential platform for studying the prolonged effects of microgravity on living organisms. By investigating the behaviors, physiological changes, and genetic mechanisms of organisms within the unique space environment, we can uncover novel scientific insights and fundamental principles of life. This knowledge will help humanity better adapt to space environments, paving the way for extended-duration space travel and exploration.” This article may be obtained online without charge.
9. Nie H, Zhou W, Zheng Z, Deng Y, Zhang W, Zhang M, Jiang Z, Zheng H, Yuan L, Yang J, Wang H.Exploring plant responses to altered gravity for advancing space agriculture.Plant Commun. 2025 May 9:101370. Review.Note: This article may be obtained online without charge.
10. Ravichandran V, Krishnan B, Tinwala M, Kumar A, Jobby R.Microbial resilience in space: Biofilms, risks and strategies for space exploration.Life Sci Space Res. 2025 May 10. Review. Online ahead of print.
11. Supolkina NS, Shved DM, Yusupova AK, Gushchin VI, Ryumin OO.Prevailing phenomena in cosmonaut communication within the crew-mission control center communication system and wanted modifications.Hum Physiol. 2025 May 12;50(7):802-7.
12. Swain P, Santos F, Hughes L, Gordon D, Caplan N.Jumping on the Moon as a potential exercise countermeasure.Exp Physiol. 2025 May 11. Online ahead of print.Note: From the abstract: “The Moon’s gravitational field strength (17% Earth’s gravity) may facilitate the use of bodyweight jumping as an exercise countermeasure against musculoskeletal and cardiovascular deconditioning in reduced gravity settings. The present study characterized the acute physiological and kinetic responses to bodyweight jumping in simulated Lunar gravity.” This article may be obtained online without charge.
13. Cutigni M, Cucina G, Galante E, Cerri M, Bizzarri M.Microgravity impairs endocrine signaling and reproductive health of women. A narrative review.Front Physiol. 2025 May 13;16:558711. Review.Note: This article is part of Research Topic “Exploring Frontiers: Astroparticle, Space Science and Public Health for Future Crewed Space Missions” (https://www.frontiersin.org/research-topics/63490/exploring-frontiers-astroparticle-space-science-and-public-health-for-future-crewed-space-missions/overview). The Research Topic also includes articles from previous Current Awareness Lists #993 https://doi.org/10.3389/fpubh.2022.862598, #1,027 https://doi.org/10.3389/fspas.2022.949432, #1,049 https://doi.org/10.3389/fspas.2023.1117811, #1,124 https://doi.org/10.3389/fphys.2024.1486767, #1,127 https://doi.org/10.3389/fphys.2024.1482860, #1,137 https://doi.org/10.3389/fimmu.2025.1538421, and #1,146 https://doi.org/10.3389/fphys.2025.1558625. This article may be obtained online without charge.
14. Koizumi T, Soga K, Wakabayashi K, Suzuki M, Muranaka T, Hoson T.Hypocotyls of Arabidopsis hmg mutants have an altered growth response to hypergravity.Biol Sci Space. 2025 May 13;39:1-8.Note: This article may be obtained online without charge.
15. Burtscher J, Kopp M, Gassmann M, Burtscher M.Health benefits of life at moderate altitude: Does hypoxia matter?Front Physiol. 2025 May 12;16:1598275.Note: This article may be obtained online without charge.
16. Puchkova AA, Shpakov AV, Baranov VM, Katuntsev VP, Stavrovskaya DM, Primachenko GK, Gorbachev VP, Tomilovskaya ES, Orlov OI.General results of a 21-day head-down bedrest study without use of countermeasures.Hum Physiol. 2025 May 12;50(7):808-16.
17. Shenkman BS.From activity to inactivity and back to activity. Signaling processes in the postural muscle in the transition period.Hum Physiol. 2025 May 12;50(7):743-57.
18. Shumski EJ, Barany DA, Schmidt JD, Lynall RC.The influence of concussion history on turning gait performance.Gait Posture. 2025 Sep;121:93-100.
19. Zandi A, Hosseinirad S, Kashani Zadeh H, Tavakolian K, Cho B-K, Vasefi F, Kim MS, Tavakolian P.A systematic review of multi-mode analytics for enhanced plant stress evaluation.Front Plant Sci. 2025 Apr 29;16:1545025.Note: From the abstract: “The advantages of MMA over conventional single-mode techniques are significant, particularly in the detection and management of plant stress in challenging environments. Integrating advanced analytical methods supports precision agriculture by enabling proactive responses to stress conditions. These innovations are pivotal for enhancing food security in terrestrial and space agriculture, ensuring sustainability and resilience in food production systems.” This article may be obtained online without charge.
20. Smirnov NN, Lomakin EV.Safety in space flights – Basic problems and applications.Acta Astronaut. 2025 May 15. Online ahead of print.

Astrobiology, space biology, space life science, microgravity, space medicine,