NASA Spaceline Current Awareness List #1,166 12 September 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Papers deriving from NASA support:

1. Rithidech K, Mohallem R, Aryal UK, Peanlikhit T, Crucian B.Effects of the space environment and re-adaptation to Earth’s gravity on astronauts’ plasma proteome.Life Sci Space Res. 2025 Sep 9. Online ahead of print.PI: K. RithidechNote: ISS results.
   
   Journal Impact Factor: 2.8
   
   Funding: “This research was supported by the National Aeronautics and Space Administration (NASA) Grant # NNX16AH80G, awarded to Dr. Rithidech. Proteomic analysis was performed at the Purdue Proteomics Facility, Bindley Bioscience Center. The authors wish to thank the International Space Station astronauts who participated in this study. The authors thank the NASA Human Research Program, Human Health, and Countermeasures Element for the selection and support of this investigation.”
2. Crucian B, Diak DM, Garbino A, Gutierrez C, Bustos-Lopez S, Colorado A, Young M, Smith SM, Zwart SR, Oswald TM, Hew-Yang MY, Estep P, Marshall-Goebel K, Mehta S.Effects of hypoxia/hyperoxia exposure on immune function – Results from a spacecraft-relevant hypobaric chamber study.Front Physiol. 2025 Sep 8;16:1637834.Note: This article and an article below (Gorini Pereira et al.) in the “Other” section are part of Research Topic “Bioconvergence: A New Frontier for Understanding and Enhancing Human Adaptations to Extreme Environments” (https://www.frontiersin.org/research-topics/68632/bioconvergence-a-new-frontier-for-understanding-and-enhancing-human-adaptations-to-extreme-environments). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
   
   Journal Impact Factor: 3.4
   
   Funding: “The author(s) declare that financial support was received for the research and/or publication of this article. The overall chamber study as a Program level evaluation was funded by the NASA JSC Extravehicular Activity and Human Surface Mobility Program. This included the immunological sub-study, for all immediate analyses. Additional funding for analysis of all frozen biosamples was provided by the NASA Human Research Program, Human Health and Countermeasures Element.”
3. Rhoades J, Mangle K, de León P, Crisman K, Manyapu K.Study on parastronaut ingress and egress of Orion and Boeing CST-100 starliner space vehicles.Acta Astronaut. 2025 Nov;236:904-13.Note: From the abstract: “This preliminary investigation aimed to observe individuals with disabilities participating in the ingress and egress procedures of Lockheed Martin’s Orion and Boeing’s CST-100 Starliner spacecraft.”
   
   Journal Impact Factor: 3.4
   
   Funding: “The National Aeronautics and Space Administration funded this project. Grant Number: 22-NUP2022-0061; UNSOL_FY2022.”
4. Tays GD, McGregor HR, De Dios YE, Mulder E, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler RD.Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Front Neurol. 2025 Aug 26;16:1602104.PI: R.D. SeidlerNote: This article is part of Research Topic “Impact of Vestibular Dysfunction Studies on Space Flight Health Challenges” (https://www.frontiersin.org/research-topics/53190/impact-of-vestibular-dysfunction-studies-on-space-flight-health-challenges). The Research Topic also includes articles from previous Current Awareness Lists #1,075 https://doi.org/10.3389/fneur.2023.1284029, #1,139 https://doi.org/10.3389/fneur.2025.1556553, and #1,164 https://doi.org/10.3389/fneur.2025.1628938. This article may be obtained online without charge.
   
   Journal Impact Factor: 2.8
   
   Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA 80NSSC18K0783) to RS, AM, SW, and JB. During the completion of this work GT was supported by the University of Florida’s (UF) Graduate Student Funding Award and by NIH T32-NS082128.”
5. Pham J, Isquith J, Balaian L, Nandi SP, Engstrom C, Mack K, van der Werf I, Chang P, Stoudemire J, Ladel L, Klacking E, Ruiz A, Chilin-Fuentes D, Sneifer J, Mays D, Gamble P, Giza S, Janowitz J, Nienaber T, Mishra T, Khachatrian AA, Molina E, Snyder MP, Morris SR, Clements T, Muotri AR, Whisenant T, Alexandrov LB, Jamieson CHM.Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell Stem Cell. 2025 Sep 4;32(9):1403-20.e8.Note: This article may be obtained online without charge.
   
   Journal Impact Factor: 20.4
   
   Funding: “…This work was supported by the Sanford Stem Cell Institute, the SCRM microscopy core, and the NGS Core Facility of the Salk Institute. We are grateful to our funding agencies for their vital support, including NASA (NRA NNJ13ZBG001N) to UC San Diego Sanford ISSCOR Center, NIH (R01CA296974), NCI (R01CA2 05944), NIH/NIDDK (R01DK114468-01), NIH NCI CCSG p30CA023100, NIH NCI CCSG: P30 CA01495, NIH NIA San Diego Nathan Shock Center (P30 AG068635), the Chapman Foundation and the Helmsley Charitable Trust, LLS Blood Cancer Discoveries, Koman Family Foundation, JM Foundation, and Moores Family Foundation.”
6. Sakharkar A, Chen R, LeRoy E, Nelson TM, Proszynski J, Kim J, Park J, Arikatla MR, Mathyk B, Mason CE.Multi-omics profiling of individuals sustaining extreme physical stressors.Life. 2025 Sep 1;15(9):1377.PI: C.E. MasonNote: This article is part of Special Issue “Space Medicine Advancements: From Human Health to Biomedical System Design” (https://www.mdpi.com/journal/life/special_issues/P9T6CD6J32) and may be obtained online without charge.
   
   Journal Impact Factor: 3.4
   
   Funding: “The National Institutes of Health (U54AG089334), NASA (80NSSC23K0832), The UK Cancer Grand Challenges (SAMBAI-01), and the Leukemia and Lymphoma Society (MCL7001-18, LLS 9238-16, 7029-23/22).”

Other papers of interest:

1. Gorini Pereira F, Ryan CT, Miller S, Watters A, Mickleborough TD, Schlader ZJ, Bell C, Johnson BD.The thermogenic effect of mirabegron ingestion during cool conditions.Front Physiol. 2025 Sep 10;16:1645475.Note: This article and an article above (Crucian et al.) in the “NASA” section are part of Research Topic “Bioconvergence: A New Frontier for Understanding and Enhancing Human Adaptations to Extreme Environments” (https://www.frontiersin.org/research-topics/68632/bioconvergence-a-new-frontier-for-understanding-and-enhancing-human-adaptations-to-extreme-environments). This article may be obtained online without charge.
2. Canay EI, Carante M, Casali A, Bernardini E, Dondi D, Vadivel D, Cansolino L, Delgrosso E, Ferrari C, Pullia M, Bonforte F, Riback J, Gonzalez S, Vercesi V, Ballarini F, Ramos R.Incorporation of dose-rate effects into the BIANCA biophysical model and application for space radiation risk assessment.Life Sci Space Res. 2025 Sep 9. Online ahead of print.
3. Clemente-Villalba J, Cerdá-Bernad D.Functional food as a nutritional countermeasure to health risks from microgravity and space radiation in long-term spaceflights: A review.Applied Sciences. 2025 Aug 21;15(16):9220. Review.Note: This article is part of Special Issue “Functional Foods: Product Development, Technological Trends and Safety” (https://www.mdpi.com/journal/applsci/special_issues/XOMRCI8B23). This article may be obtained online without charge.
4. Mendoza-Arzate A, Hernández-Chávez A, Robles-Rangel MA, Martinez-Tapia RJ.Cardiovascular effects of exposure to microgravity: A literature review.Cardiology. 2025 Sep 8;1-27. Review. Online ahead of print.
5. Petersen E, Milas K, Stabenau K, Wisbach G.Space medicine: Role of the surgeon.In: Schlussel AT, Holt DB, Lim RB, Worlton TJ, Ritter EM, eds. The SAGES Manual for Navigating a Successful Military Surgical Career. Cham: Springer Nature Switzerland, 2025. p. 489-513.
6. Vartanian O, Bouak F, Lam Q, Miles R.Initial psychometric validation of a self-report measure of the symptoms of mild hypoxic hypoxia.Aerosp Med Hum Perform. 2025 Sep 1;96(9):851-6.Note: From the abstract: “There has been long-standing interest in the physiological and psychological effects of mild hypoxia on aircrew, but to date there is no psychometrically valid self-report measure of subjective symptoms. To address this gap, we developed a self-report scale along three dimensions of impairment: cognitive, sensory, and affective. We administered this scale to active and retired aircrew (N = 354) with on average 25.04 yr (SD = 11.27) of military service and subjected their responses to exploratory factor analysis using Maximum Likelihood Estimation, followed by reliability analysis to determine cohesiveness of associated items.”
7. Canepa CA, Stabenau KA.Surgical capabilities in spaceflight.Surgical Clinics. 2025 Sep 2. Online ahead of print.
8. Kumar M, Thakur S.Culinary horizons: Exploring space food in the era of space tourism.In: Rana VS, Raina A, Bathla G, eds. Global Sustainable Practices in Gastronomic Tourism. Hershey, PA: IGI Global Scientific Publishing, 2025. p. 137-54.
9. Huang X, Zhang Y, Li H, An Q, Zhao G.SLiG-Net: A joint pose optimization network for space robot grasping under low-light conditions in on-orbit operations.Acta Astronaut. 2025 Sep 9. Online ahead of print.Note: From the abstract: “On-orbit space operations face the dual challenges of low illumination and microgravity environments, which adversely affect the accurate recognition and grasping of targets by space robots, thereby limiting their autonomous operational capabilities. To address grasping under low-light conditions in space, this paper proposes SLiG-Net, a joint optimization method for grasp pose estimation.”
10. Lv H, Hao B.Convolutional neural network and long short-term memory hybrid model-based gait prediction for spacesuit intelligent assistive device in low gravity environment.Acta Astronaut. 2025 Nov;236:199-212.
11. Kass JR, Kass R.Gleaning from diaries in long-duration isolation.Aerosp Med Hum Perform. 2025 Sep 1;96(9):829-40
12. Yurdakul EM, Karaçar E.Space tourism and recreation in space travel: Potential tourist views on recreational activities in microgravity environments and a new form of corporate social responsibility.Current Issues in Tourism. 2025 Aug 4;1-20. Online ahead of print.
13. Ge P, Wang SY, Zhang X, Yang YQ, Lv MQ, Sun Y, Zhang J, Wang XT, Liu M, Zhou DX.C/EBP- β/MeCP2/Wnt axis participates in the testicular injury in rats under simulated microgravity conditions.Reprod Sci. 2025 Sep 5. Online ahead of print.
14. Chen L, Wang S, Cai C, Cui J, Liu H, Fu Y.Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity.Life Sci Space Res. 2025 Sep 10. Online ahead of printNote: A random positioning machine was used in this study to simulate microgravity.
15. Kleischmann F, Vowinckel B, Meiburg E, Luzzatto-Fegiz P.Long-term microgravity experiments reveal a new mechanism for particle aggregation in suspension.npj Microgravity. 2025 Sep 9;11(1):63.Note: This article may be obtained online without charge.
16. Tian R, Wu X, Tan Y, Ding D, Qu L, Yang X, Wang C, Wang Y, Gong T, Yin X, Li Y, Fan Y, Sun L.Primary cilia shortening alters osteocyte mechanotransduction: Spaceflight vs. simulated microgravity.Acta Astronaut. 2025 Sep 11. Online ahead of print.Note: From the abstract: “Microgravity conditions in space lead to bone loss in the weight-bearing bones of astronauts, with alterations in osteocyte mechanotransduction considered a key cause of this weightlessness-induced bone loss. The primary cilia of osteocytes, which project from their surface, can sense fluid flow and convert shear stress signals into biochemical responses. Our previous studies demonstrated a reduction in both the number of ciliated cells and the ciliary length of MLO-Y4 osteocytes under clinostat- induced simulated microgravity (SMG). In this study, we investigated the effects of simulated microgravity on the transport velocity of intraflagellar transport proteins within cilia and further examined how osteocyte ciliary shortening impacts the downstream Ca2+-Calmodulin-NO signaling pathway and subsequent osteogenic regulatory functions.”
17. Culliton K, Melkus G, Sheikh A, Liu T, Berthiaume A, Armbrecht G, Trudel G.Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 days of bedrest.Journal of Bone and Mineral Research. 2025 Aug 28. Online ahead of print.Note: This article may be obtained online without charge.
18. Ouyang X-L, Liu J-Y, Li Z-L, Zhu J-Y, Li W-J, He R, Liu S-J, Xue Y, Huang C, Zhang J-F, Han L, Wang L-J, Wu J-W, Wang H-J, Huang Y-P, Li J-L, Dai X-Q, Zhao B-X.Transcutaneous electrical acupoint stimulation prevents bone loss and muscle atrophy induced by hindlimb suspension in rats.World J Tradit Chin Med. 2025 Aug 20;9900:10.4103.Note: This article may be obtained online without charge.
19. Festa EK, Kim IY, Winder AT, Bracken BK, Desrochers PC, Endsley MR.Physiological measurement of situation awareness: A study of the validity of EEG and fNIRS during performance and automation monitoring in a complex task.Ergonomics. 2025 Sep 5;1-19. Online ahead of print.
20. Emslie NA, Liley JB, Johnston P.Pilot ultraviolet A exposures in the cockpit of flying commercial aircraft.Aerosp Med Hum Perform. 2025 Sep 1;96(9):803-9.Note: From the abstract: “Pilots have an increased incidence of cutaneous melanoma compared to the general population; occupational exposure to ultraviolet (UV) radiation is one of several potential risk factors. Cockpit windshields effectively block UVB (280-315 nm) but further analysis is needed for UVA (315-400 nm). The objective of this observational study was to assess transmission of UVA through cockpit windshields and to measure doses of UVA at pilots’ skin under daytime flying conditions.”
21. Lingscheid R, Albracht K, Goell F, Nuesse R, Rein R, Braunstein B.Real-flight observations of head and trunk movements of fast jet pilots.Aerosp Med Hum Perform. 2025 Sep 1;96(9):810-8.Note: From the abstract: “Military fast jet pilots face significant physical challenges, including high Gz accelerations during dynamic maneuvers. The objectives of this study were threefold: 1) to record pilot movements during real flights, 2) to quantify head and trunk movements under standardized Gz conditions and during basic fighter maneuvers (BFMs), and 3) to categorize compensatory strategies used to mitigate physical strain.”
22. Panic H, Wexler D, Stephanian B, Pedro Correia J, Sides M, Hoffman T.Otolaryngological and neuro-vestibular considerations for commercial spaceflight.Aerosp Med Hum Perform. 2025 Sep 1;96(9):841-50. Review.Note: From the abstract: “The rapidly expanding commercial spaceflight (CSF) market has fueled increasing interest in spaceflight experiences among individuals without professional astronaut qualifications. Such individuals may present with a range of medical conditions that add uncertainties to medical preparation and risk assessment for spaceflight. As the ear, nose, and throat (ENT) working group of the Aerospace Medical Association Ad Hoc Committee on Commercial Spaceflight, we conducted a scoping review to assess the available biomedical literature for ENT and neuro-vestibular conditions and physiology pertinent to spaceflight for nonprofessional space travelers.”

astrobiology, spacebiology, spacemedicine, microgravity, ISS,